Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy

Supe, Shibani; Upadhya, Archana; Tripathi, S.D.; Dighe, Vikas; Singh, Kavita

doi:10.1007/s13346-022-01281-9

Cited by 9 publications

(4 citation statements)

References 91 publications

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“…Liposome-polyethyleneimine complexes have been used to deliver HuR siRNA by injection into the eyes of diabetic rats with retinopathy. The disease-causing overexpression of VEGF, which is controlled by HuR, was overcome via the HuR siRNA duplexes (Supe et al, 2023). Overall, these strategies targeting HuR provide a promising therapeutic approach in the treatment of several pathologies, including cardiometabolic disorders.…”

Section: Discussionmentioning

confidence: 99%

“…To assess the onset of DR using fundoscopic examinations, a study was conducted on streptozotcin (STZ)‐induced diabetic rats, which serves as model for DR. It was found that the onset of DR was accompanied by an increase in HuR mRNA expression, indicating upregulation of HuR in DR. HuR mRNA levels were also significantly reduced after HuR siRNA treatment in STZ‐induced diabetic rats (Supe et al, 2023).…”

Section: The Role Of Hur In the Pathogenesis Of Cardiometabolic Disor...mentioning

confidence: 99%

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Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders

Abdelsam,

Ghanem,

Zahid

et al. 2024

Journal Cellular Physiology

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RNA‐binding proteins (RBPs) play a crucial role in the regulation of posttranscriptional RNA networks, which can undergo dysregulation in many pathological conditions. Human antigen R (HuR) is a highly researched RBP that plays a crucial role as a posttranscriptional regulator. HuR plays a crucial role in the amplification of inflammatory signals by stabilizing the messenger RNA of diverse inflammatory mediators and key molecular players. The noteworthy correlations between HuR and its target molecules, coupled with the remarkable impacts reported on the pathogenesis and advancement of multiple diseases, position HuR as a promising candidate for therapeutic intervention in diverse inflammatory conditions. This review article examines the significance of HuR as a member of the RBP family, its regulatory mechanisms, and its implications in the pathophysiology of inflammation and cardiometabolic illnesses. Our objective is to illuminate potential directions for future research and drug development by conducting a comprehensive analysis of the existing body of research on HuR.

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Section: Discussionmentioning

confidence: 99%

Section: The Role Of Hur In the Pathogenesis Of Cardiometabolic Disor...mentioning

confidence: 99%

Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders

Abdelsam,

Ghanem,

Zahid

et al. 2024

Journal Cellular Physiology

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“…Supe et al used LPP-loaded human antigen R (HuR) siRNA to effectively alleviate diabetic retinopathy (DR) in rats. 173 Persano et al used LPP loaded with OVA mRNA to reduce B16-OVA-based tumor nodules by more than 90% in mice after injection. 174 Biochemical hybrid supports allow for the relatively easy and precise synthesis of chemical carriers with good biocompatibility and modification targeting ability.…”

Section: Polymer Delivery Systemsmentioning

confidence: 99%

“…Lipid–polymer hybrid carriers, also known as lipid polymers (LPPs), are a promising class of organic–organic hybrid carriers in which the lipid component can be cationic/ionizable lipids, phospholipids, cholesterol, or PEG–lipids and the polymer component can be polylactic–coglycolic acid (PLGA) or dendritic polymers. Supe et al used LPP-loaded human antigen R (HuR) siRNA to effectively alleviate diabetic retinopathy (DR) in rats . Persano et al used LPP loaded with OVA mRNA to reduce B16-OVA-based tumor nodules by more than 90% in mice after injection .…”

Section: Other Mrna Delivery Systemsmentioning

confidence: 99%

Lipid Nanoparticle-Based Delivery System─A Competing Place for mRNA Vaccines

Zhang,

Li,

Zhou

2024

ACS Omega

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mRNA, as one of the foci of biomedical research in the past decade, has become a candidate vaccine solution for various infectious diseases and tumors and for regenerative medicine and immunotherapy due to its high efficiency, safety, and effectiveness. A stable and effective delivery system is needed to protect mRNAs from nuclease degradation while also enhancing immunogenicity. The success of mRNA lipid nanoparticles in treating COVID-19, to a certain extent, marks a milestone for mRNA vaccines and also promotes further research on mRNA delivery systems. Here, we explore mRNA vaccine delivery systems, especially lipid nanoparticles (LNPs), considering the current research status, prospects, and challenges of lipid nanoparticles, and explore other mRNA delivery systems.

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Analysis of RNA Interference Targeted Against Human Antigen R (HuR) to Reduce Vascular Endothelial Growth Factor (VEGF) Protein Expression in Human Retinal Pigment Epithelial Cells

Supe,

Dighe,

Upadhya

et al. 2023

Mol Biotechnol

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Liposome-polyethylenimine complexes for the effective delivery of HuR siRNA in the treatment of diabetic retinopathy

Cited by 9 publications

References 91 publications

Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders

Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders

Lipid Nanoparticle-Based Delivery System─A Competing Place for mRNA Vaccines

Analysis of RNA Interference Targeted Against Human Antigen R (HuR) to Reduce Vascular Endothelial Growth Factor (VEGF) Protein Expression in Human Retinal Pigment Epithelial Cells

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