Lipid Nanoparticle-Based Delivery System─A Competing Place for mRNA Vaccines

Zhang, Xinyu; Li, Yuanfang; Zhou, Zehua

doi:10.1021/acsomega.3c08353

Cited by 3 publications

(1 citation statement)

References 174 publications

(289 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No introduction is complete without mention of the nanoparticles used to deliver mRNA including, but not limited to, lipid nanoparticles [5]. These are undoubtedly the best-known vaccine nanoparticles (although perhaps the general public do not recognise them as that!).…”

Section: Introductionmentioning

confidence: 99%

Nanocapsules Comprised of Purified Protein: Construction and Applications in Vaccine Research

Skakic,

Taki,

Francis

et al. 2024

Vaccines

View full text Add to dashboard Cite

Nanoparticles show great promise as a platform for developing vaccines for the prevention of infectious disease. We have been investigating a method whereby nanocapsules can be formulated from protein, such that the final capsules contain only the cross-linked protein itself. Such nanocapsules are made using a silica templating system and can be customised in terms of size and porosity. Here we compare the construction and characteristics of nanocapsules from four different proteins: one a model protein (ovalbumin) and three from infectious disease pathogens, namely the influenza virus, Helicobacter pylori and HIV. Two of the nanocapsules were assessed further. We confirm that nanocapsules constructed from the urease A subunit of H. pylori can reduce subsequent infection in a vaccinated mouse model. Further, we show that capsules constructed from the HIV gp120 protein can be taken up by dendritic cells in tissue culture and can be recognised by antibodies raised against the virus. These results point to the utility of this method in constructing protein-only nanocapsules from proteins of varying sizes and isoelectric points.

show abstract

Section: Introductionmentioning

confidence: 99%

Nanocapsules Comprised of Purified Protein: Construction and Applications in Vaccine Research

Skakic,

Taki,

Francis

et al. 2024

Vaccines

View full text Add to dashboard Cite

show abstract

Enhancing Vaccine Efficacy and Stability: A Review of the Utilization of Nanoparticles in mRNA Vaccines

Parvin,

Joo,

Mandal

2024

Biomolecules

View full text Add to dashboard Cite

The development of vaccines has entered a new era with the advent of nanotechnology, particularly through the utilization of nanoparticles. This review focuses on the role of nanoparticles in enhancing the efficacy and stability of mRNA vaccines. Nanoparticles, owing to their unique properties such as high surface area, tunable size, and their ability to be functionalized, have emerged as powerful tools in vaccine development. Specifically, lipid nanoparticles (LNPs) have revolutionized the delivery of mRNA vaccines by protecting the fragile mRNA molecules and facilitating their efficient uptake by cells. This review discusses the various types of nanoparticles employed in mRNA vaccine formulations, including lipid-based, polymer-based, and inorganic nanoparticles, highlighting their advantages and limitations. Moreover, it explores the mechanisms by which nanoparticles improve immune responses, such as enhanced antigen presentation and the prolonged release of mRNA. This review also addresses the challenges and future directions in nanoparticle-based vaccine development, emphasizing the need for further research to optimize formulations for broader applications. By providing an in-depth analysis of the current advancements in and potential of nanoparticles in mRNA vaccines, this review aims to shed light on their critical role in combating infectious diseases and improving public health outcomes.

show abstract

An Overview of Nanoparticle-Based Delivery Platforms for mRNA Vaccines for Treating Cancer

Lin,

Chen,

Wang

et al. 2024

Vaccines

View full text Add to dashboard Cite

With its unique properties and potential applications, nanoparticle-based delivery platforms for messenger RNA (mRNA) vaccines have gained significant attention in recent years. Nanoparticles have the advantages of enhancing immunogenicity, targeting delivery, and improving stability, providing a new solution for drug and vaccine delivery. In some clinical studies, a variety of nanoparticle delivery platforms have been gradually applied to a wide range of vaccine applications. Current research priorities are exploring various types of nanoparticles as vaccine delivery systems to enhance vaccine stability and immunogenicity. Lipid nanoparticles (LNPs) have shown promising potential in preclinical and clinical studies on the efficient delivery of antigens to immune cells. Moreover, lipid nanoparticles and other nanoparticles for nucleic acids, especially for mRNA delivery systems, have shown vast potential for vaccine development. In this review, we present various vaccine platforms with an emphasis on nanoparticles as mRNA vaccine delivery vehicles. We describe several novel nanoparticle delivery platforms for mRNA vaccines, such as lipid-, polymer-, and protein-based nanoparticles. In addition, we provide an overview of the anti-tumor immunity of nanovaccines against different tumors in cancer immunotherapy. Finally, we outline future perspectives and remaining challenges for this promising technology of nanoparticle-based delivery platforms for vaccines.

show abstract

Lipid Nanoparticle-Based Delivery System─A Competing Place for mRNA Vaccines

Cited by 3 publications

References 174 publications

Nanocapsules Comprised of Purified Protein: Construction and Applications in Vaccine Research

Nanocapsules Comprised of Purified Protein: Construction and Applications in Vaccine Research

Enhancing Vaccine Efficacy and Stability: A Review of the Utilization of Nanoparticles in mRNA Vaccines

An Overview of Nanoparticle-Based Delivery Platforms for mRNA Vaccines for Treating Cancer

Contact Info

Product

Resources

About