Liposome encapsulation improves efficacy of betamethasone dipropionate in atopic eczema but not in psoriasis vulgaris

Abstract

The effect of a liposomal preparation of beta-methasone dipropionate (0.039%, BDP) has been compared to that of a commercial propylene glycol-gel containing 0.064% BDP in a double-blind, randomized, paired trial lasting 14 d in 10 patients with atopic eczema and 10 patients with psoriasis vulgaris. In eczema, the liposome preparation tended to reduce erythema and scaling more than the conventional gel, the difference in the latter parameter being significant on Day 7. There was greater improvement of psoriasis on the side treated with the reference gel. Hence, liposome encapsulation of BDP may increase the antiinflammatory action but not the antiproliferative effect. Since inhibition of mitotic activity is linked to the atrophogenicity of topical corticosteroids, the results suggest that liposome encapsulation may improve the benefit-risk ratio in eczema.

Clinical assessment of the combination therapy with liposomal gels of tretinoin and benzoyl peroxide in acne

“…Although liposomal drug gels caused no adverse symptoms from the 4th week of treatment, some symptoms were observed in the initial phase of treatment. This agrees with the findings of Korting et al [13] that liposomal formulation of betamethasone reduced erythema and scaling more than a conventional gel and did so more rapidly. This can be further correlated to less free drug being available with liposomal encapsulation [14], which produced better results and thus improved patient compliance to a larger extent.…”

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

“…In addition, it was shown that vesicles can penetrate a ruptured or diseased SC as in case of eczema but cannot transport a skin with psoriasis or hyperkeratosis conditions [31]. On the other hand, Zellmer et al [32], and Korting et al [33] indicated that there was no evidence of intact liposomal carrier penetration after skin application of liposomes made from DMPC "1,2-dimyristoyl-sn-glycero-3-phosphocholine" or soy-lecithin.…”

Corticosteroids for Skin Delivery: Challenges and New Formulation Opportunities

“…Korting et al [61] compared the efficacy of betamethasone dipropionate encapsulated in liposomes and cream. The liposomes were prepared with egg lecithine and incorporated in a polyacrylate gel.…”