Liposome-encapsulated curcumin: <i>in vitro</i> and <i>in vivo</i> effects on proliferation, apoptosis, signaling, and angiogenesis

Kurzrock, Razelle; Li, L.

doi:10.1200/jco.2005.23.16_suppl.4091

Cited by 24 publications

(15 citation statements)

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“…An exophytic tumor mass showing decrease in tumor volume which was statistically significant lower than G-B with mean tumor volume of tumor-bearing animals was 201.9 mm 3 . These results are in agreement with other studies which report the growth suppressive effects of curcumin on HNSCC (6,(28)(29)(30) . Guha et al reported that growth suppression effect was done by the effect of curcumin on the nuclear factor kB (NF-kB) signaling pathway.…”

Section: Discussionsupporting

confidence: 93%

Therapeutic efficacy of intraperitoneally injected curcumin on experimentally induced hamster buccal pouch carcinoma

Mohammed

Mohamady

2021

Al-Azhar Journal of Dental Science

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Objective:The aim of the present study was directed to investigate the therapeutic efficacy of intraperitoneally injected curcumin as anticarcinogenic treatment modality on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch(s) (HBP(s)) carcinoma. Subjects and methods: Materials and Methods: Thirty Syrian male hamsters, five weeks old, weighing 90-130g were divided into three group(s) (G(s)): A, B, and C. G-A (negative control): HBP mucosa of 10 animals were painted with liquid paraffin alone three times a week for 14 weeks. G-B (positive control): 10 animals were painted with 0.5% DMBA in paraffin oil 3 times a week for 14 weeks. Then animals were left untreated for 6 weeks after DMBA painting. G-C (curcumin treated group): 10 animals were injected intraperitoneally with curcumin 80 mg/kg body weight every day for 6 weeks following DMBA-treatment. The assessment was based on the gross observation, histological and immunohistochemical examination utilizing anti-apoptotic Bcl-2 antibody. Results: Gross observation revealed variation in reduction of the tumor size in the treated group (G-C) compared to that observed in group G-B. Histopathological findings revealed variations between G-B and G-C groups. Immunohistochemical results revealed that Bcl-2 expression has a variability in the area % throughout the groups used. Groups G-A, G-B, and G-C were 7.78%, 75.51%, and 41.65% respectively. Conclusion: The therapeutic effect of intraperitoneally injected curcumin resulted in promising outcome in regression of DMBA induced HBP carcinoma.

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Section: Discussionsupporting

confidence: 93%

Therapeutic efficacy of intraperitoneally injected curcumin on experimentally induced hamster buccal pouch carcinoma

Mohammed

Mohamady

2021

Al-Azhar Journal of Dental Science

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“…These systems have been reported to promote the biological activities of curcumin such as improved drug levels in cells 24 , increased antioxidant activity 25 , anti-angiogenic activity 26 , and anticancer activity 27 The morphology of the bilayer dispersions was assessed by transmission electron microscopy TEM . Differential scanning calorimetric DSC studies were carried out to determine the phase transition temperature of the bilayer.…”

Section: Introductionmentioning

confidence: 99%

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

et al. 2016

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“…Lipocurc is a liposomal formulation for curcumin [186] with 100 nm mean particle size. It exhibited excellent in vitro antiproliferative activity against several pancreas cancer cell lines (ASPC-1, BxPC-3, Capan-1, Hs766-T, and MiaPaCa2), with half-maximal inhibitory concentration (IC 50 ) values within 2-7 µM, as well as tumor-reducing and anti-angiogenic effects in mice xenografted with human pancreas carcinoma (BxPC-3 and MiaPaCa2) [187]. Clinical trials (phases 1a and 1b) with Lipocurc in 70 human subjects showed no cardiac toxicity and signs of efficacy in end-stage cancer patients who had failed 6-7 prior chemotherapy regimens; results of phase 2 trials should be available soon [188].…”

Section: New Injectable Forms Of Curcuminmentioning

confidence: 99%

Curcumin Innovative Delivery Forms: Paving the ‘Yellow Brick Road’ of Antitumoral Phytotherapy

2020

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This review deals with the various aspects involved in the medicinal action of curcumin, from the photosensitivity and its relevance to storage and shelf-life, to the different routes of administration, which influence the bioavailability. The focus of the review is on the antitumor properties of curcumin and the currently available solutions for their amelioration. The work starts by presenting a brief historical perspective on the origins and uses of curcumin, from early days until the present time. The following sections describe the physico-chemical properties of curcumin and their impact on the biological activity and pharmacokinetics, raising awareness to the need for formulations able to improve the bioavailability. The last section is focused on research efforts being made to circumvent curcumin’s instability and low availability due to the extensive hepatic first pass metabolism, describing innovative scientific advances and new patented formulations and emerging products on the market.

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Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis

Cited by 24 publications

References 0 publications

Therapeutic efficacy of intraperitoneally injected curcumin on experimentally induced hamster buccal pouch carcinoma

Therapeutic efficacy of intraperitoneally injected curcumin on experimentally induced hamster buccal pouch carcinoma

Influence of Lipid Composition, pH, and Temperature on Physicochemical Properties of Liposomes with Curcumin as Model Drug

Curcumin Innovative Delivery Forms: Paving the ‘Yellow Brick Road’ of Antitumoral Phytotherapy

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