Liposomal nanoformulations of rhodamine for targeted photodynamic inactivation of multidrug resistant gram negative bacteria in sewage treatment plant

Devi, Mohan Vimala; Divya, Kurunchi C.; Girigoswami, Agnishwar

doi:10.1016/j.jphotobiol.2016.06.034

Cited by 36 publications

(14 citation statements)

References 18 publications

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“…The improvement of the photodynamic inactivation using a PS stabilized in positively charged liposomal formulations was corroborated by the results obtained by Girigoswami and co-workers [ 161 ]. The authors evaluated the effect of two liposomal formulations of xanthene dye Rhodamine 6G (R6G) ( Figure 33 ) on a multidrug resistant P. aeruginosa present in a sewage water treatment plant.…”

Section: Liposomessupporting

confidence: 75%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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Microbial infection is a severe concern, requiring the use of significant amounts of antimicrobials/biocides, not only in the hospital setting, but also in other environments. The increasing use of antimicrobial drugs and the rapid adaptability of microorganisms to these agents, have contributed to a sharp increase of antimicrobial resistance. It is obvious that the development of new strategies to combat planktonic and biofilm-embedded microorganisms is required. Photodynamic inactivation (PDI) is being recognized as an effective method to inactivate a broad spectrum of microorganisms, including those resistant to conventional antimicrobials. In the last few years, the development and biological assessment of new photosensitizers for PDI were accompanied by their immobilization in different supports having in mind the extension of the photodynamic principle to new applications, such as the disinfection of blood, water, and surfaces. In this review, we intended to cover a significant amount of recent work considering a diversity of photosensitizers and supports to achieve an effective photoinactivation. Special attention is devoted to the chemistry behind the preparation of the photomaterials by recurring to extensive examples, illustrating the design strategies. Additionally, we highlighted the biological challenges of each formulation expecting that the compiled information could motivate the development of other effective photoactive materials.

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Section: Liposomessupporting

confidence: 75%

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

et al. 2018

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“…Due to the abuse of antibiotics, microbes have adopted a large variety of mechanisms to increase their resistance towards antibiotics. 36,37 Such conditions necessitate new methods to be developed to treat microorganism infections, especially those caused by drug-resistant strains. Photodynamic antimicrobial chemotherapy (PACT) is a new method to do this, which combines photodynamic irradiation with drugs known as sensitizers to treat both cancers and infections of pathogenic microorganisms, and has produced good results.…”

Section: Discussionmentioning

confidence: 99%

“…41 Alves et al demonstrated that the photodynamic efficiency of cationic porphyrins in the photosensitization of E. coli and Enterococcus faecalis increased with the number of charges, 46 because the charge number could increase the amphiphilic character of the photosensitizers, and its affinity for bacteria increased as a result, which would help the drug to accumulate in the cells. 37,39,41 Moreover, quaternized ions signicantly increased the ability of ZnPc2 to produce singlet oxygen, which played an important role in killing cells. 23 All of the elements worked together and nally enhanced the photodynamic activity.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic antimicrobial chemotherapy with cationic phthalocyanines against Escherichia coli planktonic and biofilm cultures

Mai

Wang

et al. 2017

RSC Adv.

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“…The hypothesis was that the liposomal structure or environment can be generated by the macrophage membrane since it is made mainly of phospholipids. Therefore, the AgNC were incubated with macrophage membrane under constant sonication following the protocol mentioned in our previous work 10 . The increment in absorbance with a red-shift and fluorescence emission was observed after exciting the AgNC at 515 nm.…”

Section: Resultsmentioning

confidence: 99%

Camouflaged Nanosilver with Excitation Wavelength Dependent High Quantum Yield for Targeted Theranostic

Girigoswami

Yassine

Sharmiladevi

et al. 2018

Sci Rep

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The present study shows the thorough investigations on optical properties and hydrodynamic diameters of glutathione (GSH) stabilized nanosilver clusters (AgNC) at different stages of synthesis and engineering for the optimized absolute quantum yield to generate fluorescent images of Dalton Lymphoma Ascites (DLA) tumour bearing mice. The initial increment of quantum yield was wavelength dependent and finally it became 0.509 which was due to the camouflaging or entrapment of AgNC in macrophages membranes. The potentiality of macrophages membrane camouflaged silver nanoclusters (AgM) was reflected in the cell viability assay and confocal based live dead cell assay where the AgM has better cell killing effect compared to AgNC with reduced dosage and in vivo mice imaging generated the clear visualization at the tumour sites. Therefore, from the present study, it can be considered that the camouflaged nanosilver can be used for targeted theranostic applications.

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Liposomal nanoformulations of rhodamine for targeted photodynamic inactivation of multidrug resistant gram negative bacteria in sewage treatment plant

Cited by 36 publications

References 18 publications

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy

Photodynamic antimicrobial chemotherapy with cationic phthalocyanines against Escherichia coli planktonic and biofilm cultures

Camouflaged Nanosilver with Excitation Wavelength Dependent High Quantum Yield for Targeted Theranostic

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