Liposomal bupivacaine peripheral nerve block for the management of postoperative pain

Hamilton, Thomas W.; Athanassoglou, Vassilis; Trivella, Marialena; Strickland, Louise; Mellon, Stephen; Murray, David; Pandit, Hemant

doi:10.1002/14651858.cd011476.pub2

Cited by 40 publications

(21 citation statements)

References 30 publications

(2 reference statements)

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“…This NMA supports both the efficacy of TAP blocks at 24 h after surgery, and their reduced efficacy in the longer term, demonstrated by a lack of benefit over the systemic opiate group at 48 h. Slow‐release liposomal bupivacaine has been used in an attempt to increase the duration of effect of TAP blocks, and has been shown to be more effective than placebo for postoperative pain. However, whether this strategy is superior to non‐liposomal bupivacaine awaits further research. Unpublished trials in colorectal and gynaecological surgery may shed further light on the effectiveness of liposomal bupivacaine (NCT03638635, NCT02740114).…”

Section: Discussionsupporting

confidence: 58%

Network meta-analysis of local and regional analgesia following colorectal resection

Varghese

Bissett

et al. 2020

British Journal of Surgery

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Background Postoperative pain management after colorectal surgery remains challenging. Systemic opiates delivered on demand or via a patient‐controlled pump have traditionally been the mainstay of treatment. Opiate analgesia is associated with slower gastrointestinal recovery and unpleasant side‐effects; many regional and local analgesic techniques have been developed as alternatives. Methods MEDLINE, Embase and CENTRAL databases were searched systematically for RCTs comparing analgesic techniques after major colorectal resection. A network meta‐analysis was performed using a Bayesian random‐effects framework with a non‐informative prior. Primary outcomes included pain at rest and cumulative opiate consumption 24 h after surgery. Secondary outcomes included pain at rest and cumulative opiate consumption at 48 h, pain on movement and cough at 24 and 48 h, time to first stool, time to tolerance of oral diet, duration of hospital stay, nausea and vomiting, and postoperative complications. Results Seventy‐four RCTs, including 5101 patients and 11 different techniques, were included. Some inconsistency and heterogeneity was found. SUCRA scores showed that spinal analgesia was the best intervention for postoperative pain and opiate reduction at 24 h. Transversus abdominus plane blocks were effective in reducing pain and opiate consumption 24 h after surgery. Subgroup analysis showed similar results for open versus minimally invasive surgical approaches, and enhanced recovery after surgery programmes. Conclusion Spinal analgesia and transversus abdominus plane blocks best balanced pain control and opiate minimization in the immediate postoperative phase following colorectal resection. Multimodal analgesia reduces pain, minimizes systemic opiate use and optimizes postoperative recovery.

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Section: Discussionsupporting

confidence: 58%

Network meta-analysis of local and regional analgesia following colorectal resection

Varghese

Bissett

et al. 2020

British Journal of Surgery

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“…Pain is a common postoperative complaint following arthroplasty, particularly of the knee (Hamilton, Athanassoglou et al., ; Hamilton, Strickland et al., ; Szots, Pedersen, Hordam, Thomsen, & Konradsen, ). Pain has also been recognised as a possible cause of confusion and disorientation in the immediate postoperative phase for the elderly (Duggleby & Lander, ).…”

Section: Discussionmentioning

confidence: 99%

“…By using multimodal techniques, ranging from preoperative education to surgical site local anaesthetic wound infiltration, ERPs have been demonstrated to significantly reduce perioperative pain and opiate consumption and are associated with significant cost savings to the healthcare system through a reduced length of stay (LOS) and associated healthcare costs (Hamilton, Strickland, & Pandit, ; Hamilton, Athanassoglou et al., ;, Hamilton et al., ). In addition, the short‐term benefits seen with the use of ERPs have been reported to translate into reduced long‐term patient morbidity and mortality as well as improved functional outcomes (Ibrahim, Twaij, Giebaly, Nizam, & Haddad, ; Nicholson et al., ; Wylde et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…STRICKLAND ET AL. | 2599 Hamilton, Athanassoglou et al, 2016;, Hamilton et al, 2017). In addition, the short-term benefits seen with the use of ERPs have been reported to translate into reduced long-term patient morbidity and mortality as well as improved functional outcomes (Ibrahim, Twaij, Giebaly, Nizam, & Haddad, 2013;Nicholson et al, 2014;Wylde et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Early recovery following lower limb arthroplasty: Qualitative interviews with patients undergoing elective hip and knee replacement surgery. Initial phase in the development of a patient‐reported outcome measure

Strickland

Kelly

Hamilton

et al. 2017

Journal of Clinical Nursing

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To have specific patient-reported information regarding key areas of importance during the perioperative phase is invaluable when caring for the orthopaedic surgical patient. It gives insight and understanding in to this increasing population group. This study has also served as a starting point in the development of a questionnaire which could be used to assess interventions in the lower limb arthroplasty population. These results will influence both items and content of the questionnaire.

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“…This system allows LA deposit in the center of the liposomes, being involved by a double lipid layer. This setting allows a slower, controlled, and gradual release of LA, (72-96 h), consequently providing extended analgesic duration [20][21][22][23]. Liposomal bupivacaine (LB) has a decreased spread when compared with conventional bupivacaine.…”

Section: Liposomal Formulationsmentioning

confidence: 99%

Local Anesthetics Infiltration and Wound Healing Process

Abrão¹,

Antunes²,

Garcia³

2020

Topics in Local Anesthetics

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It is a good practice, nowadays, to infiltrate local anesthetics along the incision to prevent postoperative pain. This can reduce the use of opioids and the side effects they cause. It is known clearly that the surgical trauma causes inflammatory reaction, and this can be the beginning of a bad cicatrization or even a scar. The use of local anesthetics preventing the acute pain is a very simple technique and has proved to be useful. Nevertheless, the reaction that various anesthetics have over the tissues and the cicatrization process is yet controversial and deserves to be investigated deeply. The use of different formulations of these drugs has been stimulated. The duration and secureness have been the goals of many researches. Levobupivacaine, ropivacaine, and bupivacaine for their long action; lidocaine for less toxicity; and liposomal formulation for the longest duration ever seen, all of them have been indicated in the postoperative pain management. The aim of this chapter is to evaluate the role of long duration local anesthetics on the inflammatory reaction and consequently the collagen production and resistance of the tissue to traction.

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Liposomal bupivacaine peripheral nerve block for the management of postoperative pain

Cited by 40 publications

References 30 publications

Network meta-analysis of local and regional analgesia following colorectal resection

Network meta-analysis of local and regional analgesia following colorectal resection

Early recovery following lower limb arthroplasty: Qualitative interviews with patients undergoing elective hip and knee replacement surgery. Initial phase in the development of a patient‐reported outcome measure

Local Anesthetics Infiltration and Wound Healing Process

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