Local Anesthetics Infiltration and Wound Healing Process

Abrão, João; Antunes, Marcelo B.; Garcia, Luís Vicente

doi:10.5772/intechopen.89278

Cited by 7 publications

(7 citation statements)

References 57 publications

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“…13 Trauma bedah termasuk dalam hal ini adalah insisi pada operasi seksio sesarea menyebabkan reaksi inflamasi. 15 Anestesi lokal memblokir saluran natrium voltage-gated pada ujung saraf. Aplikasi anestesi lokal langsung ke luka memberikan analgesia dengan menghalangi transmisi sinyal nyeri dari aferen nosiseptif di permukaan luka dan dengan menghambat respon inflamasi lokal terhadap cedera, sehingga mengurangi pelepasan mediator inflamasi dari neutrofil dan mengurangi pembentukan edema.…”

Section: Pembahasanunclassified

“…Oleh karena bupivakain menghasilkan lebih banyak blokade sensorik daripada motorik, maka berperan penting dalam kontrol nyeri pascaoperasi. 15 Teknik infiltrasi dengan bupivakain 0,5% dapat digunakan untuk memberikan anestesi pada prosedur bedah minor durasi durasi aksi yang panjang. 13 Hasil penelitian ini menunjukkan bahwa anestesi infiltrasi dapat menurunkan signifikan kadar IL-6 dibandingkan tanpa anestesi infiltrasi dan pada anestesi infiltrasi sebelum insisi menunjukkan penurunan kadar IL-6 yang lebih cepat (4 jam pascabedah seksio sesarea) dan lebih besar dibandingkan setelah insisi.…”

Section: Pembahasanunclassified

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Efek Anestesi Infiltrasi terhadap Intensitas Nyeri dan Kadar Interleukin-6 pada Pasca Seksio Sesarea

Isbul

Ahmad

Gaus

et al. 2023

JAOI

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Latar Belakang: Nyeri menjadi permasalahan yang sering dihadapi oleh wanita pascabedah seksio caesarea yang ditandai dengan meningkatnya kadar interluekin-6. Anestesi infiltrasi intraoperatif direkomendasikan pada seksio caesarea elektif sebagai manajemen nyeri.Tujuan: Menilai efek anestesi infiltrasi bupivakain isobarik 0,25% 50 mg pada luka insisi terhadap intensitas nyeri dan kadar IL-6 pada pascabedah seksio sesarea. Subjek dan Metode: Penelitian ini menggunakan pendekatan uji klinis acak tersamar ganda. Sampel terdiri atas 3 kelompok yaitu kontrol (B0), diberi anestesi infiltrasi bupivakain sebelum insisi (B1), dan diberi anestesi infiltrasi bupivakain setelah insisi dan sebelum luka ditutup (B2) dengan jumlah sampel masing-masing 8 orang. Data dianalisis menggunakan uji Anova, Kruskal Wallis dan paired t-test dengan tingkat kemaknaan α=0,05. Hasil: Skor nyeri berbeda signifikan antara kelompok anestesi infiltrasi dengan kontrol pada 8 jam pascabedah (p<0,05). Kadar interleukin-6 berbeda signifikan antara kelompok anestesi infiltrasi dengan kontrol dan antara anestesi infiltrasi sebelum dengan setelah insisi pada 4 jam pasca bedah (p<0,05). Anestesi infiltrasi sebelum insisi menurunkan kadar interleukin-6 lebih besar dibandingkan setelah insisi mulai dari 4 jam pascabedah seksio sesarea.Simpulan: Pemberian anestesi infiltrasi sebelum insisi dapat menurunkan kadar interleukin-6 lebih cepat dan lebih besar daripada setelah insisi dan juga mengurangi intensitas nyeri

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Section: Pembahasanunclassified

Efek Anestesi Infiltrasi terhadap Intensitas Nyeri dan Kadar Interleukin-6 pada Pasca Seksio Sesarea

Isbul

Ahmad

Gaus

et al. 2023

JAOI

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“…Epinephrine could be used to lengthen the duration of action and decrease drug toxicity. Local anesthesia might also have an important role in eicosanoid, fibroblast formation, and scar tissue formation in wound healing (Abrão et al, 2020).…”

Section: Table 2 Measurement Of Apoptosis On the Third And Seventh Daymentioning

confidence: 99%

“…Analgetic drugs such as Non Steroid Anti Inflamatory Drug (NSAID) that are administered on wound healing phases showed non satisfactory result in reducing pain after wound formation, therefore multimodal analgesics are needed to accelerate wound healing. One of the methods that accelerates wound healing process is by infiltration of local anaesthesia (LA) around incision wound, that aims to reduce sensitization and hyperalgesia therefore accelerates wound healing, and subcutaneous administration shows bacteriostatic and bactericidal properties (Abrão et al, 2020;Brower et al, 2003). LA infiltration reduces the release of inflammation mediators of neutrophils, decrease oxidant formation, edema formation, and reduce adhesion of neutrophils on cell endothels (Hollmann et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Effect ropivacaine infiltration in incisional wound on caspase-3 expression and apoptosis squamous cells wound healing

Abdurrahman

Airlangga

Susilo

2022

ijhs

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Wound healing and tissue regeneration consist of molecular and cellular process that occur right after wound formation. The intrinsic pathway of apoptosis, apoptosome produced to initiate the formation of Caspase 3 important role in apoptosis. One of the methods that accelerates wound healing process by eliminating pain by infiltration of local anesthesia. This study aims to determine the effect of ropivacaine infiltration as local anaesthesia in the expression of Caspase 3 and apoptosis. This study is an experimental study with randomized post-test only control group design. The samples of this study were 24 wistar rats. The rats divided into four groups then incised, either followed by 1 ml ropivacaine 0.2% infiltration or left as is. Excisional biopsy procedures were done on third and seventh day. Then analyzed by SPSS. Expression of Caspase 3 on squamous cell epithel of control and intervention group was found statistically different on day 3 (p=0.024) and day 7 (p=0.041). Number of apoptosis on squamous cell epithel of control and intervention was found statistically different on day 7 (p=0.031) but not on day 7 (p=0.414). Ropivacaine infiltration on incision wound decreased the expression of Caspase 3 on day 3 and 7; and apoptosis on day 7.

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“…Consequently, sensitization of nociceptive receptors, and the ensuing hyperalgesia may be prevented. 5 The LA may be administered by pre-or post-incisional abdominal nerve block or pre-or post-incisional abdominal wound infiltration. [6][7][8] It may also be administered by continuous wound irrigation at the end of the procedure.…”

Section: Introductionmentioning

confidence: 99%

Local Infiltration of Bupivacaine along the Incision Line following Cesarean Section reduces Postoperative Pain and Analgesia Requirement: A Double-blinded Randomized Controlled Study

Saboo¹,

Biswas²,

Naz³

et al. 2022

Journal of South Asian Federation of Obstetrics and Gynaecology

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Introduction:Cesarean delivery commonly induces moderate to severe pain lasting for 48 hours. Any form of intervention that leads to improvement in pain relief can positively impact ability to breast feed early. Infiltration of local anesthetics (LAs) into the surgical wound is a simple, safe, and low-cost technique for postoperative analgesia. Systemic side effects seen with central neural blockades are avoided. Analgesic requirements are also reduced. Risks of LA toxicity are very low or negligible. Aims and objectives: To compare the effect on postoperative analgesia of bupivacaine (BP) infiltration into the incision line vs normal saline (NS) infiltration after cesarean section (CS) by analyzing pain-free interval, pain score, and overall analgesic consumption in first 24 postoperative hours. Materials and methods: A prospective, double-blinded, randomized controlled study was conducted in the Department of Obstetrics and Gynecology, RG Kar Medical College and Hospital over 1 year including 130 patients undergoing cesarean delivery under spinal anesthesia. Before skin closure, 30 mL 0.25% BP or NS infiltration was infiltrated over incision line (10 mL in rectus sheath; 10 mL for each upper and lower subcutaneous flap). Postoperatively, the patients were evaluated at 2, 4, 6, 12, and 24 hours. Analgesic drugs were considered on pain score above 4 on visual analog scale (VAS). Diclofenac intramuscularly 75 mg was given on the first request and tramadol on second, if VAS was above 4 within 12 hours. Results: Mean time of first analgesic demand was 274.30 minutes in BP group whereas 149.15 minutes in NS group (p <0.0001). Pain scores (on VAS) were significantly reduced for up to 6 hours postoperatively in BP group as compared to NS group (at 2 hours, p = 0.000 and at 6 hours, p = 0.007). There was no statistical difference in pain scores in two groups beyond 6 hours. In BP group, 58.46% patients required only 75 mg of intramuscular diclofenac and 41.54% patients required 150 mg of diclofenac in two divided doses whereas in NS group; only 23.08% patients had pain control by 75 mg of intramuscular diclofenac and 76.92% required 150 mg (p = 0.0001). In addition to diclofenac, 26.15% patients in NS group required 100 mg of tramadol vs only 7.7% in BP group (p = 0.0101). Conclusion: Direct infiltration of 0.25% BP along incision line following cesarean delivery under spinal anesthesia prolongs pain-free interval, provides adequate analgesia for 1st few postoperative hours, reducing requirement of systemic analgesic in first 24 postoperative hours with negligible side effects.

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Local Anesthetics Infiltration and Wound Healing Process

Cited by 7 publications

References 57 publications

Efek Anestesi Infiltrasi terhadap Intensitas Nyeri dan Kadar Interleukin-6 pada Pasca Seksio Sesarea

Efek Anestesi Infiltrasi terhadap Intensitas Nyeri dan Kadar Interleukin-6 pada Pasca Seksio Sesarea

Effect ropivacaine infiltration in incisional wound on caspase-3 expression and apoptosis squamous cells wound healing

Local Infiltration of Bupivacaine along the Incision Line following Cesarean Section reduces Postoperative Pain and Analgesia Requirement: A Double-blinded Randomized Controlled Study

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