Liposomal-Based Pharmaceutical Formulations – Current Landscape, Limitations and Technologies for Industrial Scale-Up

Rani, Radha; Raina, Neha; Khan, Azmi; Choudhary, Manupriya; Gupta, Madhu

doi:10.1201/9781003043164-13

Cited by 4 publications

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“…Liposomes are lipid bilayer structures that can carry therapeutic agents of hydrophilic nature between the core bilayer and lipophilic drugs. Numerous liposome-based medications and biomedical products have been approved for medicinal use in recent years since they are nontoxic . Melatonin (MLT) embedded elastic liposomes employing the method of thin-film dispersion were formulated to slow down the process of skin aging.…”

Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

“…Numerous liposome-based medications and biomedical products have been approved for medicinal use in recent years since they are nontoxic. 175 Melatonin (MLT) embedded elastic liposomes employing the method of thin-film dispersion were formulated to slow down the process of skin aging. These liposomes were prepared with the aim of enhancing the poor solubility and bioavailability limitations associated with the oral administration of MLT.…”

Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

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New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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Skin, the largest organ in humans, is an efficient route for the delivery of drugs as it circumvents several disadvantages of the oral and parenteral routes. These advantages of skin have fascinated researchers in recent decades. Drug delivery via a topical route includes moving the drug from a topical product to a locally targeted region with dermal circulation throughout the body and deeper tissues. Still, due to the skin's barrier function, delivery through the skin can be difficult. Drug delivery to the skin using conventional formulations with micronized active components, for instance, lotions, gels, ointments, and creams, results in poor penetration. The use of nanoparticulate carriers is one of the promising strategies, as it provides efficient delivery of drugs through the skin and overcomes the disadvantage of traditional formulations. Nanoformulations with smaller particle sizes contribute to improved permeability of therapeutic agents, targeting, stability, and retention, making nanoformulations ideal for drug delivery through a topical route. Achieving sustained release and preserving a localized effect utilizing nanocarriers can result in the effective treatment of numerous infections or skin disorders. This article aims to evaluate and discuss the most recent developments of nanocarriers as therapeutic agent vehicles for skin conditions with patent technology and a market overview that will give future directions for research. As topical drug delivery systems have shown great preclinical results for skin problems, for future research directions, we anticipate including in-depth studies of nanocarrier behavior in various customized treatments to take into account the phenotypic variability of the disease.

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Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

Self Cite

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“…The drug encapsulation efficiency achieved 90%, reaching a ratio of 800 g irinotecan per mole of phospholipid within liposomes. The half-life of the drug delivered by this system was 56.8 h following administration [170].…”

Section: Liposomal Formulations In Antitumorigenic Drugs and Vaccines...mentioning

confidence: 99%

Trends in Drug Delivery Systems for Natural Bioactive Molecules to Treat Health Disorders: The Importance of Nano-Liposomes

et al. 2022

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Drug delivery systems are believed to increase pharmaceutical efficacy and the therapeutic index by protecting and stabilizing bioactive molecules, such as protein and peptides, against body fluids’ enzymes and/or unsuitable physicochemical conditions while preserving the surrounding healthy tissues from toxicity. Liposomes are biocompatible and biodegradable and do not cause immunogenicity following intravenous or topical administration. Still, their most important characteristic is the ability to load any drug or complex molecule uncommitted to its hydrophobic or hydrophilic character. Selecting lipid components, ratios and thermo-sensitivity is critical to achieve a suitable nano-liposomal formulation. Nano-liposomal surfaces can be tailored to interact successfully with target cells, avoiding undesirable associations with plasma proteins and enhancing their half-life in the bloodstream. Macropinocytosis-dynamin-independent, cell-membrane-cholesterol-dependent processes, clathrin, and caveolae-independent mechanisms are involved in liposome internalization and trafficking within target cells to deliver the loaded drugs to modulate cell function. A successful translation from animal studies to clinical trials is still an important challenge surrounding the approval of new nano-liposomal drugs that have been the focus of investigations. Precision medicine based on the design of functionalized nano-delivery systems bearing highly specific molecules to drive therapies is a promising strategy to treat degenerative diseases.

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Wound-Healing Effects of Curcumin and Its Nanoformulations: A Comprehensive Review

et al. 2022

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Wound healing is an intricate process of tissue repair or remodeling that occurs in response to injury. Plants and plant-derived bioactive constituents are well explored in the treatment of various types of wounds. Curcumin is a natural polyphenolic substance that has been used since ancient times in Ayurveda for its healing properties, as it reduces inflammation and acts on several healing stages. Several research studies for curcumin delivery at the wound site reported the effectiveness of curcumin in eradicating reactive oxygen species and its ability to enhance the deposition of collagen, granulation tissue formation, and finally, expedite wound contraction. Curcumin has been widely investigated for its wound healing potential but its lower solubility and rapid metabolism, in addition to its shorter plasma half-life, have limited its applications in wound healing. As nanotechnology has proven to be an effective technique to accelerate wound healing by stimulating appropriate mobility through various healing phases, curcumin-loaded nanocarriers are used for targeted delivery at the wound sites. This review highlights the potential of curcumin and its nanoformulations, such as liposomes, nanoparticles, and nano-emulsions, etc. in wound healing. This paper emphasizes the numerous biomedical applications of curcumin which collectively prepare a base for its antibiofilm and wound-healing action.

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Liposomal-Based Pharmaceutical Formulations – Current Landscape, Limitations and Technologies for Industrial Scale-Up

Cited by 4 publications

References 0 publications

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

Trends in Drug Delivery Systems for Natural Bioactive Molecules to Treat Health Disorders: The Importance of Nano-Liposomes

Wound-Healing Effects of Curcumin and Its Nanoformulations: A Comprehensive Review

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