Liposarcoma of the stomach: Report of two cases and review of the literature

Abstract

Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a well-differentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present.

Laparoscopic management of gastric liposarcoma: A case report and review of the literature

“…It is caused by the proliferation of undifferentiated mesenchymal cells (lipoblasts) within the submucosa and the muscular layer of the stomach. The gastric antrum is the most common location, with 75 % of cases; lesion diameter varies from 1.2–30 cm [ 1 , 4 ] In a study by Frank et al, 1933 cases of liposarcoma were described, of which only 0.31 % were gastric liposarcomas [ 3 ], this is the reason why it is crucial to understand the importance of this pathology. This neoplasm can remain asymptomatic for a long time due to its extraluminal growth.…”

“…Likewise, CT is the best imaging technique to detect secondary lesions in the liver, lungs, and peritoneum. [ 3 , 4 ] Alternatively, ultrasound can be useful for tumors larger than 2 cm, due to the submucosa of the tumor [ 1 , 4 ] However, the diagnosis is confirmed only with histopathological examination of the surgical specimen. Standard preoperative biopsies are often inadequate due to the submucosal location of the tumor.…”

“…This type has a variation called "round cell" that is more at risk of metastasis. Pleomorphic liposarcoma is the least common type; it is highly malignant and shows high mitotic activity, hemorrhage, and necrosis [ 1 ]. Mortality can reach 80 % for visceral or retroperitoneal tumors [ 4 ].…”

“…Liposarcoma of the gastrointestinal tract is rare, representing only 2% of total cases. To the best of our knowledge, there are less than 50 cases of gastric liposarcoma reported in the world literature [ [1] , [2] , [3] ]…”

Giant myxoid liposarcoma of the stomach: Report of a case

“…About 40 cases of liposarcoma of the stomach have been reported to date, and two preoperative histological diagnoses were confirmed by endoscopic biopsy. Most biopsy specimens were diagnosed as inflammatory mucosa, erosion, or lipoma [3,[10], [11], [12], [13]].…”