Liposarcoma of the head and neck: Analysis of 318 cases with comparison to non–head and neck sites

Gerry, Daniel; Fox, Nyssa F.; Spruill, Laura; Lentsch, Eric J.

doi:10.1002/hed.23311

Cited by 63 publications

(50 citation statements)

References 7 publications

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“…In particular, Gerry et al [25] showed that patients with head and neck liposarcomas receiving only radiation therapy had significantly a worse outcome than patients receiving either surgical resection or surgery plus adjuvant radiotherapy. Davis et al [26] recommended surgery with negative margin resection as the treatment of choice in head and neck liposarcomas.…”

Section: Discussionmentioning

confidence: 99%

Liposarcoma of the Thyroid: A Case Report with a Review of the Literature

Guarda

Pickhard

Boxberg³

et al. 2018

Eur Thyroid J

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Background: Liposarcomas of the thyroid gland are extremely rare tumors, and, to our knowledge, only 12 cases have been reported in the English literature. An accurate diagnosis is challenging due to the nonspecific clinical presentation of this cancer, frequently defined just by a swelling of the neck. Patient Findings: We present an 82-year-old woman with liposarcoma of the thyroid, complaining of a fast-growing neck mass. MRI and neck ultrasound showed a large lipomatous mass, which corresponded to a cold nodule in the thyroid scan. After performing a total thyroidectomy, the diagnosis of a well-differentiated liposarcoma of the thyroid gland was made, showing an MDM2 amplification in fluorescence in situ hybridization. Since neither a metastasis nor a residual tumor was found, no further adjuvant therapy was needed. Results: We searched the literature for previous case reports and identified only 12 cases worldwide to form our database. A demographic as well as clinical and histopathological analysis was made. In most cases, the liposarcoma occurred in patients >60 years of age. All histological subtypes, such as well-differentiated and myxoid liposarcomas, and pleomorphic and dedifferentiated liposarcomas, were found in the literature. In only 38.46% of the cases, an infiltration of the adjacent organs was observed. Surgery was the most common treatment chosen. Conclusions: Our review provides clinical and histopathological features of a primary liposarcoma of the thyroid to enable the identification of this rare tumor entity and assist in the decision-making process regarding therapeutic options and tumor follow-up.

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Section: Discussionmentioning

confidence: 99%

Liposarcoma of the Thyroid: A Case Report with a Review of the Literature

Guarda

Pickhard

Boxberg³

et al. 2018

Eur Thyroid J

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show abstract

“…Of these, myxoid liposarcoma continues to be the most common in the head and neck region with ∼79% of the cases. Our patient had mostly a myxoid component; however, areas of rounded cells were present in 20% of the fields studied in the surgical specimen [9].…”

Section: Discussionmentioning

confidence: 61%

“…This is demonstrated in the study by Gerry et al [9] where 79.6% of the patients were treated exclusively with surgery for head and neck tumors. The anatomic location makes it very difficult to perform surgery with wide margins in comparison with other locations such as the trunk or extremities due to the closeness of neural and vascular structures which, if resected, are associated with significant morbidity.…”

Section: Case Reportmentioning

confidence: 86%

“…Risk factors for developing this type of tumor are unknown. Gerry et al [9] report that the combined incidence in the larynx and hypopharynx was 6%. This study also reveals that the biologic behavior of head and neck liposarcomas is more favorable than those of the trunk.…”

Section: Discussionmentioning

confidence: 99%

“…These generally occur in the soft tissues of the neck [9]. There have been ∼30 cases of this type of tumor in the hypopharynx with a male: female ratio of 9:1 [4].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Recurrent Larynx and Hypopharyngeal Liposarcoma with Systemic Progression

Luna-Ortiz¹,

Rodríguez-García²,

Basave³

2017

J Clin Case Rep

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Foreign Body Sensation in the Throat

Chiou

Kuo

Chu

2015

JAMA Otolaryngol Head Neck Surg

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A man in his 40s with a 10-year history of smoking 180 packs of cigarettes per year choked easily and had experienced a foreign body sensation in his throat for 6 months. He was a tour guide, a profession that requires speech. Because he experienced voice fatigue frequently, he visited a hospital for professional assistance. Fibroscopy showed a wellcircumscribed mass of approximately 3 × 3 × 2 cm, with a smooth surface, located at the laryngeal side of the left aryepiglottic fold and covering nearby structures, such as the bilateral vocal cords and left pyriform sinus (Figure 1, A). A biopsy was performed, and the patient visited our institution (Taipei Veterans General Hospital) for further intervention. The laryngeal mass was removed through transoral laser microsurgery. The tumor was at the submucosa with focally ulcerated overlying epithelium. It was composed of adipocytes of various sizes in a fibromyxoid background. In the fibromyxoid areas, atypical spindle cells with hyperchromatic and enlarged nuclei were present, as well as scattered lipoblasts without areas of dedifferentiation (Figure 1, B). Immunohistochemically, the tumor exhibited substantial nuclear staining for both CDK4 and MDM2 and stains (Figure 1, C).

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Liposarcoma of the head and neck: Analysis of 318 cases with comparison to non–head and neck sites

Abstract: Liposarcomas of the head and neck are usually early stage, low grade, and with fewer nodal metastases than conventional liposarcomas. DSS and OS were significantly greater for liposarcomas of the head and neck.

Cited by 63 publications

References 7 publications

Liposarcoma of the Thyroid: A Case Report with a Review of the Literature

Liposarcoma of the Thyroid: A Case Report with a Review of the Literature

Recurrent Larynx and Hypopharyngeal Liposarcoma with Systemic Progression

Foreign Body Sensation in the Throat

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