Lipoproteins from normolipidemic and dyslipidemic subjects modify the thromboxane A2 generation by platelets in clotting human blood

Beitz, Alvin J.; Perova, N. V.; Nikitina, N.A.; Beitz, J.; Scherbakova, Ioana; Giessler, C; Mest, H.‐J.

doi:10.1016/0952-3278(93)90054-z

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…It is generally long-term increases (on timescales of years) in cholesterol that have been associated with adverse cardiovascular outcomes, and the implications of short-term changes in cholesterol due to short-term changes in temperature are unclear. In vitro, it has been shown that HDL can inhibit platelet activation, and LDL, from persons with moderate hypercholesterolemia or high cholesterol, can increase platelet activity within an hour from the beginning of the experiment (Beitz et al, 1993). Platelet activation promotes arterial thrombosis and further increases the risk of myocardial infarction and ischemic stroke that are conditions that have been associated with temperature increase (Basu and Ostro, 2008; Dawson et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Outdoor temperature is associated with serum HDL and LDL

Halonen¹,

Zanobetti²,

Sparrow

et al. 2011

Environmental Research

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Background While exposures to high and low air temperatures are associated with cardiovascular mortality, the underlying mechanisms are poorly understood. The risk factors for cardiovascular disease include high levels of total cholesterol and low-density lipoprotein (LDL), and low levels of high-density lipoprotein (HDL). We investigated whether temperature was associated with changes in circulating lipid levels, and whether this might explain part of the association with increased cardiovascular events. Methods The study cohort consisted of 478 men in the greater Boston area with a mean age of 74.2 years. They visited the clinic every 3–5 years between 1995–2008 for physical examination and to complete questionnaires. We excluded from analyses all men taking statin medication and all days with missing data, resulting in a total of 862 visits. Associations between three temperature variables (ambient, apparent, and dew point temperature) and serum lipid levels (total cholesterol, HDL, LDL, and triglycerides) were studied with linear mixed models that included possible confounders such as air pollution and a random intercept for each subject. Results We found that HDL decreased −1.76% (95% CI: −3.17 – −0.32, lag 2 days), and −5.58% (95% CI: −8.87 – −2.16, moving average of 4 weeks) for each 5°C increase in mean ambient temperature. For the same increase in mean ambient temperature, LDL increased by 1.74% (95% CI: 0.07 – 3.44, lag 1 day) and 1.87% (95% CI: 0.14 – 3.63, lag 2 days). These results were also similar for apparent and dew point temperatures. No changes were found in total cholesterol or triglycerides in relation to temperature increase. Conclusions Changes in HDL and LDL levels associated with an increase in ambient temperature may be among the underlying mechanisms of temperature-related cardiovascular mortality.

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Section: Discussionmentioning

confidence: 99%

Outdoor temperature is associated with serum HDL and LDL

Halonen¹,

Zanobetti²,

Sparrow

et al. 2011

Environmental Research

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“…It is therefore not clear if the effect of Lp(a) is strictly at the level of the platelet or is, at least partially, mediated via other blood components. Changes in platelet aggregation levels can be mediated by lipoprotein-induced alterations in thromboxane A 2 (T3 A 2 ) production by platelets, 2 and as such might explain any Lp(a) mediated fluctuations in platelet aggregation.…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein (a) reduces platelet aggregation apo(a)-mediated decreases in production via thromboxane A 2

De¹

1998

Platelets

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Agonist (collagen- or ADP-)-stimulated platelet aggregation and thromboxane B(2) (T X B(2) ) production was reduced in human whole blood (WB) and washed platelets (WP) that were co-incubated with lipoprotein (a)[Lp(a)] at levels of 25, 50 and 100 mg % but not at 5 mg % relative to a baseline concentration of 1 mg %. Significant decreases in agonist-stimulated aggregation and T X B(2) levels were seen with 5, 25, 50 and 100 mg %purified apo (a) that was co-incubated with WB and WP relative to a baseline concentration of 1 mg %. Purified Lp(a) that was free of apo(a) [Lp(a)(-)], at concentrations of 5, 25, 50 and 100 mg %, that were co-incubated with WB and WP, had no impact on agonist-induced platelet aggregation and T X B(2) production relative to a baseline level of 1 mg %. A monoclonal antibody (Mab) (3B1) against apo(a) blocked Lp(a)-mediated reduction in platelet aggregation and T X B(2) concentrations in WB and WP that were stimulated by either agonist. Various Mabs against apoB failed to affect an Lp(a)-induced reduction in WB and WP aggregation or T X B(2) levels in response to either agonist. These results strongly suggest that Lp(a)-induced decreases in collagen or ADP stimulated platelet aggregation and T X B(2) production are mediated by apo(a).

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Antiatherosclerotic potency of high density lipoprotein of different origins: a review and some new findings

Beitz

1998

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Lipoproteins from normolipidemic and dyslipidemic subjects modify the thromboxane A2 generation by platelets in clotting human blood

Cited by 7 publications

References 12 publications

Outdoor temperature is associated with serum HDL and LDL

Outdoor temperature is associated with serum HDL and LDL

Lipoprotein (a) reduces platelet aggregation apo(a)-mediated decreases in production via thromboxane A 2

Antiatherosclerotic potency of high density lipoprotein of different origins: a review and some new findings

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