Lipoprotein response to a National Cholesterol Education Program step II diet with and without energy restriction

Flynn, Mary M.; Zmuda, Joseph M.; Milosavljevic, Dragana; Caldwell, M. J.; Herbert, Peter N.

doi:10.1016/s0026-0495(99)90212-3

Cited by 25 publications

(20 citation statements)

References 42 publications

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“…Reduction in saturated fat and increase in physical activity, key elements of the ILS intervention, may alter lipoprotein subfractions (22,23). However, these factors had little effect on the noted changes.…”

Section: Discussionmentioning

confidence: 96%

Lifestyle and Metformin Treatment Favorably Influence Lipoprotein Subfraction Distribution in the Diabetes Prevention Program

Goldberg

Temprosa

Otvos

et al. 2013

The Journal of Clinical Endocrinology & Metabolism

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Section: Discussionmentioning

confidence: 96%

Lifestyle and Metformin Treatment Favorably Influence Lipoprotein Subfraction Distribution in the Diabetes Prevention Program

Goldberg

Temprosa

Otvos

et al. 2013

The Journal of Clinical Endocrinology & Metabolism

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“…Thus, middle-aged and older men were chosen for the study. Weight loss and lipid profile changes with exercise and diet take at least 12 weeks and many previous investigators have used that timeframe (19,20). Therefore, the study ended after 3 months.…”

Section: Discussionmentioning

confidence: 99%

Investigating the effects of negative-calorie diet compared with low-calorie diet under exercise conditions on weight loss and lipid profile in overweight/obese middle-aged and older men

Rezaeipour

Apanasenko²,

Nychyporuk³

2014

Turk J Med Sci

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Background/aim: Negative-calorie diets (NCDs) are among the popular dieting guides for weight loss; however, there is still little knowledge about this method. The present study aimed to determine the effects of a NCD supplemented with exercise on weight loss and lipid profile, and to compare its efficiency with low-calorie diets (LCDs) with exercise among elderly adult men with abnormal weight gain. Materials and methods:Participants included sedentary men (aged 45-75 years) who were overweight or obese (n = 37). They were randomly divided into 2 groups: a group with a NCD and exercise, and a group with a LCD with exercise. Of all 37 participants, 30 completed the treatment. Weight assessment parameters, including changes in weight and body composition and blood sample tests, were performed before and 3 months after intervention.Results: All parameters decreased significantly in both groups. Elevation in high-density lipoprotein (HDL) cholesterol levels (P < 0.001) was different between the 2 groups. The decline in the total cholesterol to HDL cholesterol ratio was greater in the LCD than the NCD group. Conclusion:Contrary to expectations, both weight-loss diets were equally efficacious.

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“…This diet produced changes in some (e.g., LDL-C, HDL-C) and but not in all (e.g., triglycerides, TC: HDL-C ratio) CVD risk factors. Flynn et al 20 also studied the Step 2 diet in 20 hypercholesterolemic subjects (10 men, 10 postmenopausal women) for 4 weeks and found that compared to a high-fat and high-saturated fat “baseline” diet, the step II diet reduced TC and LDL-C ( as well as HDL-C) and increased VLDL-cholesterol and the TC: HDL-C ratio. When these same investigators combined the step II diet with an energy restriction to produce weight loss, the lipoprotein response was improved.…”

Section: Discussionmentioning

confidence: 99%

Exercise effects on lipids in persons with varying dietary patterns—does diet matter if they exercise? Responses in Studies of a Targeted Risk Reduction Intervention through Defined Exercise I

Huffman

Hawk

Henes

et al. 2012

American Heart Journal

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Background The standard clinical approach for reducing cardiovascular disease risk due to dyslipidemia is to prescribe changes in diet and physical activity. The purpose of the current study was to determine if, across a range of dietary patterns, there were variable lipoprotein responses to an aerobic exercise training intervention. Methods Subjects were participants in the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE I), a supervised exercise program in sedentary, overweight subjects randomized to 6 months of inactivity or one of 3 aerobic exercise programs. To characterize diet patterns observed during the study, we calculated a modified z-score that included intakes of total fat, saturated fat, trans fatty acids, cholesterol, omega-3 fatty acids and fiber as compared to the 2006 AHA diet recommendations. Linear models were used to evaluate relationships between diet patterns and exercise effects on lipoproteins/lipids. Results Independent of diet, exercise had beneficial effects on LDL-cholesterol particle number, LDL-cholesterol size, HDL-cholesterol, HDL-cholesterol size, and triglycerides (P<0.05 for all). However, having a diet pattern that closely adhered to AHA recommendations was not related to changes in these or any other serum lipids or lipoproteins in any of the exercise groups. Conclusions We found that even in sedentary individuals whose habitual diets vary in the extent of adherence to AHA dietary recommendations, a rigorous, supervised exercise intervention can achieve significant beneficial lipid effects.

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Lipoprotein response to a National Cholesterol Education Program step II diet with and without energy restriction

Cited by 25 publications

References 42 publications

Lifestyle and Metformin Treatment Favorably Influence Lipoprotein Subfraction Distribution in the Diabetes Prevention Program

Lifestyle and Metformin Treatment Favorably Influence Lipoprotein Subfraction Distribution in the Diabetes Prevention Program

Investigating the effects of negative-calorie diet compared with low-calorie diet under exercise conditions on weight loss and lipid profile in overweight/obese middle-aged and older men

Exercise effects on lipids in persons with varying dietary patterns—does diet matter if they exercise? Responses in Studies of a Targeted Risk Reduction Intervention through Defined Exercise I

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