Lipoprotein Particles in Hypertriglyceridemic States

Alaupovic, P.; Tavella, Marcelo; Bard, Jean‐Marie; Wang, C. S.; Attman, Per‐Ola; Koren, Eugen; Corder, Clinton N.; Knight-Gibson, Carolyn; Downs, Deborah

doi:10.1007/978-1-4613-0733-4_37

Cited by 17 publications

(3 citation statements)

References 11 publications

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“…We have recently shown that the characteristic features of dyslipoproteinemia in advanced renal failure are in creased levels of triglyceride-rich LP-B:C and LP-B:C:E particles with normal or only slightly increased levels of cholesterol-rich LP-B particles [15,16]. This is also reflected in the plasma apolipoprotein profile of these patients in cluding increased concentrations of ApoB and ApoC-III [4], Although results of this study do not allow identification of a particular ApoB-containing lipoprotein family as the main contributor to the rate of progression of renal insuffi ciency, it appears from the increased concentrations of ApoB, ApoC-III and triglycerides in patients with a more rapid progression that some intact or partially delipidized triglyceride-rich lipoproteins might have a greater impact on this process than cholesterol-rich LP-B particles.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein-B-Containing Lipoproteins and the Progression of Renal Insufficiency

Samuelsson

Aurell

Knight-Gibson

et al. 1993

Nephron

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Hyperlipidemia is associated with accelerated glomerular sclerosis in experimental renal insufficiency. To investigate whether the dyslipoproteinemia seen in human renal failure also influences the future course of renal insufficiency, we have correlated plasma levels of lipids and apolipoproteins at start of follow-up with the subsequent change in renal function in 34 adult patients with chronic renal disease. Nineteen patients had primary renal disease, and 15 patients had diabetic nephropathy. Except for antihypertensive therapy no specific treatment to modify the progression of the disease was given during the follow-up. The rate of progression was determined by repeated measurements of the glomerular filtration rate (GFR). The time of follow-up ranged from 12 to 91 months with an average of 39.7 ± 16.7 months. The mean initial GFR was 34.7 ± 13.9 ml/min× 1.73 m² body surface area and the average decline in renal function was -0.27 ± 0.26 ml/min/month. The entry levels of triglycerides (TG; p = 0.04), very-low-density lipoprotein cholesterol (p = 0.03), apolipoprotein-B (ApoB; p = 0.008) and systolic blood pressure (SBP; p = 0.04) were significantly correlated with the rate of progression. Among lipoprotein variables, ApoB showed the strongest correlation with the decline in GFR. Patients with a progressive course of their disease also tended to have initially higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (NS), whereas the initial plasma concentration of high-density lipoprotein cholesterol did not show an association with the progression of renal insufficiency. The rate of progression was shown to be much higher in patients with initially high levels of both ApoB and SBP than in patients with initially low levels of these variables. There was no difference between diabetic and nondiabetic patients with respect to initial ApoB and BP levels and the rate of progression. The results of this study suggest that altered lipoprotein metabolism has a significant effect on the progression of renal failure. In particular, increased plasma concentrations of ApoB-containing lipoproteins seem to be linked to a more rapid development of renal insufficiency, and the combination of dyslipoproteinemia and hypertension may act synergistically to promote the progression of chronic renal failure.

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Section: Discussionmentioning

confidence: 99%

Apolipoprotein-B-Containing Lipoproteins and the Progression of Renal Insufficiency

Samuelsson

Aurell

Knight-Gibson

et al. 1993

Nephron

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“…Small quantities of apoCIII are also found in intermediate-density lipoprotein (IDL) and LDL particles , . ApoCIII is also found as a component of particles with defined lipid and apolipoprotein composition such as LpB:E:CIII, LpAI:AII:CIII, and other combinations , . In addition, in vitro experiments have established that association of purified lipid-free apoCIII with egg lecithin forms discoidal particles with a minor axis of 4 nm and a major axis of 20 nm , .…”

mentioning

confidence: 99%

ABCA1 Promotes the de Novo Biogenesis of Apolipoprotein CIII-Containing HDL Particles in Vivo and Modulates the Severity of Apolipoprotein CIII-Induced Hypertriglyceridemia

Kypreos

2008

Biochemistry

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In this study, the ability of the lipid transporter ABCA1 and apolipoprotein CIII (apoCIII) to promote the de novo biogenesis of apoCIII-containing HDL in vivo and the role of this HDL in apoCIII-induced hypertriglyceridemia were investigated, using adenovirus-mediated gene transfer in apoE (-/-) x apoA-I (-/-) mice or ABCA1 (-/-) mice. Injection of apoE (-/-) x apoA-I (-/-) mice with 8 x 10 (8) pfu of an adenovirus expressing the wild-type human apoCIII (AdGFP-CIII g) generated HDL-like particles and triggered only a modest increase in plasma cholesterol and triglyceride levels of these mice, 3-5 days postinfection. Plasma human apoCIII was distributed among HDL, VLDL/IDL, and LDL in these mice. In contrast, ABCA1 (-/-) mice treated similarly failed to form HDL particles and developed severe hypertriglyceridemia which could be alleviated by coinfection with an adenovirus expressing human LpL, while their plasma cholesterol levels remained unchanged 3-5 days postinfection with AdGFP-CIII g. Human apoCIII in these mice accumulated exclusively on VLDL. Control experiments confirmed that the differences between apoE (-/-) x apoA-I (-/-) and ABCA1 (-/-) mice expressing human apoCIII were not due to differences in apoCIII expression. Overall, these data show that ABCA1 and human apoCIII promote the formation of apoCIII-containing HDL-like particles that are distinct from classical apoE- or apoA-I-containing HDL. Formation of apoCIII-containing HDL prevents excess accumulation of plasma apoCIII on VLDL and allows for the efficient lipolysis of VLDL triglycerides by LpL. Furthermore, the data establish that ABCA1 and apoCIII-containing HDL play key roles in the prevention of apoCIII-induced hypertriglyceridemia in mice.

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“…Lipoproteins containing apo B + apo CIII have been ascribed atherogenic properties [7–11]. Apo CIII is transported in plasma bound to apo B‐particles (apo CIII LP B) or to apo A‐particles (apo CIII LP non B) [12, 13]. Lipoprotein(a) (Lp(a)) has been extensively investigated during the last two decades because of its close relationship to LDL cholesterol and resemblance to plasminogen, suggesting that Lp(a) can have atherogenic as well as thrombogenic properties [14–18].…”

Section: Introductionmentioning

confidence: 99%

Plasma lipoprotein particle concentrations in postmenopausal women with unstable coronary artery disease. Analysis of diagnostic accuracy using receiver operating characteristics

Nielsen¹,

Olsson²,

Swahn³

2000

Journal of Internal Medicine

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Abstract. Nielsen NE, Olsson AG, Swahn E (University Hospital, Linko Èping, Sweden). Plasma lipoprotein particle concentrations in postmenopausal women with unstable coronary artery disease. Analysis of diagnostic accuracy using receiver operating characteristics. J Intern Med 2000; 247: 43±52.Background. The contribution of plasma lipids to cardiovascular risk is usually evaluated by measuring plasma concentrations of total cholesterol, triglycerides and HDL cholesterol, and calculating LDL cholesterol concentration. We investigated plasma concentrations of apolipoproteins and lipoprotein particles in women with unstable coronary artery disease (CAD) to evaluate whether these, better than the routine lipid status, could differentiate women with and without coronary atherosclerosis. Methods. Blood samples for lipid analyses were collected from 119 angiographically examined postmenopausal 49±79-year-old women with unstable CAD, and from 101 age-matched controls. Mean plasma concentrations were compared and the discriminatory ability of the different variables were tested using receiver operating characteristics (ROC). Results. At coronary angiography 19% had normal vessels and 81% had coronary atherosclerosis. A disturbed triglyceride metabolism was the most pronounced lipid abnormality in women with unstable CAD and coronary atherosclerosis. ROC showed that none of the evaluated variables had a

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Lipoprotein Particles in Hypertriglyceridemic States

Cited by 17 publications

References 11 publications

Apolipoprotein-B-Containing Lipoproteins and the Progression of Renal Insufficiency

Apolipoprotein-B-Containing Lipoproteins and the Progression of Renal Insufficiency

ABCA1 Promotes the de Novo Biogenesis of Apolipoprotein CIII-Containing HDL Particles in Vivo and Modulates the Severity of Apolipoprotein CIII-Induced Hypertriglyceridemia

Plasma lipoprotein particle concentrations in postmenopausal women with unstable coronary artery disease. Analysis of diagnostic accuracy using receiver operating characteristics

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