Lipoprotein-associated phospholipase A2 distribution among lipoproteins differs in type 1 diabetes

Jarvie, Jennifer L.; Wang, Hong; Kinney, Gregory L.; Snell‐Bergeon, Janet K.; Hokanson, John E.; Eckel, Robert H.

doi:10.1016/j.jacl.2016.01.001

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…However, our data concur with those by Miller et al [ 43 ] who reported that patients with T1DM and coronary disease have increased Lp-PLA2 after adjustment for HDL cholesterol. In contrast, other studies found no difference in Lp-PLA2 content in HDL from type 1 diabetic patients with and without atherosclerosis [ 44 ]. Lp-PLA2 is mainly bound to small, dense HDL3, and these particles are increased in subjects with atherosclerosis; thus, it is plausible that, even if we did not reach statistical differences in HDL size between the groups with or without stenosis, the increased content of Lp-PLA2 in HDL from subjects with lesions is related to its association to HDL3.…”

Section: Discussionmentioning

confidence: 76%

Associations between epicardial adipose tissue, subclinical atherosclerosis and high-density lipoprotein composition in type 1 diabetes

Colom

Viladés

Pérez-Cuellar

et al. 2018

Cardiovasc Diabetol

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BackgroundThe pathophysiology of cardiovascular complications in people with type 1 diabetes (T1DM) remains unclear. An increase in epicardial adipose tissue (EAT) and alterations in the composition of high-density lipoprotein (HDL) are associated with coronary artery disease, but information on its relationship in T1DM is very limited. Our aim was to determine the association between EAT volume, subclinical atherosclerosis, and HDL composition in type 1 diabetes.MethodsSeventy-two long-term patients with T1DM without clinical atherosclerosis were analyzed. EAT volume and subclinical atherosclerosis were measured using cardiac computed tomography angiography. EAT was adjusted according to body surface to obtain an EAT index (iEAT). HDL composition was determined.ResultsThe mean iEAT was 40.47 ± 22.18 cc/m2. The bivariate analysis showed positive associations of the iEAT with gender, age, hypertension, dyslipidemia, smoking, body mass index, waist circumference, insulin dose, and triglyceride (P < 0.05). The iEAT correlated positively with small HDL, increased content of apolipoprotein (apo)A-II and apoC-III, and decreased content of apoE and free cholesterol. Multiple linear regression showed that age, apoA-II content in HDL, and waist circumference were independently associated with the iEAT. Fifty percent of the patients presented subclinical atherosclerotic lesions. These patients had a higher iEAT, and their HDL contained less cholesterol and more apoA-II and lipoprotein-associated phospholipase A2 than patients without subclinical atherosclerosis.ConclusionAlterations in the composition of HDL in TIDM are associated with increased iEAT and the presence of subclinical atherosclerosis. We propose that these abnormalities of HDL composition could be useful to identify T1DM patients at highest cardiovascular risk.Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0794-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 76%

Associations between epicardial adipose tissue, subclinical atherosclerosis and high-density lipoprotein composition in type 1 diabetes

Colom

Viladés

Pérez-Cuellar

et al. 2018

Cardiovasc Diabetol

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“…As far as PAF catabolism is concerned, an intracellular PAF-specific acetylhydrolase (PAF-AH) and its plasma isoform lipoprotein-associated phospholipase A 2 (LpPLA 2 ) are the main enzymes for the removal of the acetyl chain at the sn-2 position forming the inactive lyso-PAF [8]. In particular, the enzyme LpPLA 2 is mainly associated with LDL, although it has also been associated with very low-density lipoproteins (VLDLs), intermediate-density lipoproteins, high-density lipoproteins (HDLs), and lipoprotein (a) [9,10]. Many studies have indicated that LpPLA 2 is an independent predictor for coronary artery disease (CAD), with elevated LpPLA 2 activity associated with an increased risk for CAD [11].…”

Section: Introductionmentioning

confidence: 99%

Consumption of Enriched Yogurt with PAF Inhibitors from Olive Pomace Affects the Major Enzymes of PAF Metabolism: A Randomized, Double Blind, Three Arm Trial

et al. 2021

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Platelet-activating factor (PAF), a proinflammatory lipid mediator, plays a crucial role in the formation of the atherosclerotic plaque. Therefore, the inhibition of endothelium inflammation by nutraceuticals, such as PAF inhibitors, is a promising alternative for preventing cardiovascular diseases. The aim of the present study was to evaluate the impact of a new functional yogurt enriched with PAF inhibitors of natural origin from olive oil by-products on PAF metabolism. Ninety-two apparently healthy, but mainly overweight volunteers (35–65 years) were randomly allocated into three groups by block-randomization. The activities of PAF’s biosynthetic and catabolic enzymes were measured, specifically two isoforms of acetyl-CoA:lyso-PAF acetyltransferase (LPCATs), cytidine 5′-diphospho-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-CPT) and two isoforms of platelet activating factor acetylhydrolase in leucocytes (PAF-AH) and plasma (lipoprotein associated phospholipase-A2, LpPLA2). The intake of the enriched yogurt resulted in reduced PAF-CPT and LpPLA2 activities. No difference was observed in the activities of the two isoforms of lyso PAF-AT. In conclusion, intake of yogurt enriched in PAF inhibitors could favorably modulate PAF biosynthetic and catabolic pathways.

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HDL Function in Diabetes

Gluba-Brzózka

Rysz-Górzyńska

Rysz

2023

Contemporary Diabetes

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Lipoprotein-associated phospholipase A2 distribution among lipoproteins differs in type 1 diabetes

Cited by 5 publications

References 34 publications

Associations between epicardial adipose tissue, subclinical atherosclerosis and high-density lipoprotein composition in type 1 diabetes

Associations between epicardial adipose tissue, subclinical atherosclerosis and high-density lipoprotein composition in type 1 diabetes

Consumption of Enriched Yogurt with PAF Inhibitors from Olive Pomace Affects the Major Enzymes of PAF Metabolism: A Randomized, Double Blind, Three Arm Trial

HDL Function in Diabetes

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