Lipoprotein‐associated phospholipase A<sub>2</sub> and plasma lipids in patients with destructive periodontal disease

Lösche, Wolfgang; Marshal, G. J.; Krause, S.; Kocher, T.; Kinane, D. F.

doi:10.1111/j.1600-051x.2005.00725.x

Cited by 59 publications

(66 citation statements)

References 40 publications

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“…Montebugnoli et al (2005) showed a mean reduction in ox-LDL of 18% in patients affected by periodontitis and CHD, whilst Tamaki et al (2011) demonstrated a 37% reduction following periodontal therapy in otherwise healthy patients. In addition, Losche et al (2005) found that the treatment of periodontitis could influence the serum activity of Lp-PLA2.…”

Section: Periodontal Treatment and Cvd Outcomes S87mentioning

confidence: 99%

Evidence that periodontal treatment improves biomarkers and CVD outcomes

D’Aiuto

Orlandi

Gunsolley

2013

Journal of Periodontology

127

137

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Evidence that periodontal treatment improves biomarkers and CVD outcomes D'Aiuto F, Orlandi M, Gunsolley JC. Evidence that periodontal treatment improves biomarkers and CVD outcomes. AbstractAim: The aim of this review was to critically appraise the evidence on the impact of periodontal treatment of cardiovascular diseases (CVDs) biomarkers and outcomes. Methods: A systematic search was performed in Cinhal, Cochrane, Embase and Medline for relevant articles up to July 2012. Duplicate screening and reference hand searching were performed. Data were then summarized and evidence graded in tables. Results: The search resulted in: (a) no evidence on the effects of periodontal therapy on subclinical atherosclerosis, serum levels of CD40 ligand, serum amyloid A and monocyte chemoattractant protein-1, (b) limited evidence on the effects of periodontal therapy on arterial blood pressure, leucocyte counts, fibrinogen, tissue necrosis factor-a, sE-selectin, von Willebrand factors, d-dimers, matrix metalloproteinases, oxidative stress and CVD events, and (c) moderate evidence suggesting a negligible effect of periodontal therapy in reducing interleukin-6 and lipids levels, whilst a positive effect in reducing serum C-reactive protein levels and improving endothelial function. Conclusions: Periodontal therapy triggers a short-term inflammatory response followed by (a) a progressive and consistent reduction of systemic inflammation and (b) an improvement in endothelial function. There is however limited evidence that these acute and chronic changes will either increase or reduce CVD burden of individuals suffering from periodontitis in the long term.

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Section: Periodontal Treatment and Cvd Outcomes S87mentioning

confidence: 99%

Evidence that periodontal treatment improves biomarkers and CVD outcomes

D’Aiuto

Orlandi

Gunsolley

2013

Journal of Periodontology

127

137

View full text Add to dashboard Cite

show abstract

“…Recent studies illustrate the existence of a relation between periodontal disorders and hyperlipidemia, which power the probable effect of periodontal disease as an underlying factor for hyperlipidemia. This theory is presented in Losche et al study, which demonstrated higher level of TGL and lower HDL among the patients suffering from periodontitis than control group significantly, 12 which was approved by some other studies. [13][14][15] The aim of the present study was to investigate the effect of nonsurgical periodontal therapy (NSPT) on the lipid levels in patients with chronic periodontitis.…”

Section: Introductionmentioning

confidence: 79%

“…TC and LDL as well as TG in patients with severe periodontitis. 12,34 However, further investigations are needed for further exploration of the relationship among periodontitis, periodontal therapy and lipid metabolism. Larger studies and clinical intervention trials are necessary to better define the periodontitis subjects in whom local infection causes significant systemic inflammation, and whether these findings are true or are confounded by other important factors like nutrition, socioeconomic status, or age.…”

Section: Jaypeementioning

confidence: 99%

“…[8][9][10] Periodontitis is often associated with endotoxemia and mild systemic inflammatory reactions and periodontal pathogens have been identified in early atherosclerotic lesions. [11][12][13] Several studies have indicated that subjects with periodontal disease may have a higher risk for cardiovascular diseases when compared to subjects with a healthy periodontium. [14][15][16][17][18] Recently, a causal relation has been demonstrated between high serum lipid levels and periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Alteration in Serum Lipid Levels in Patients with Chronic Periodontitis Postperiodontal Therapy

Thombre¹,

Thombre²,

Bhongade³

et al. 2011

JIAOMR

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Aim: There is growing evidence that periodontitis may affect general health. This study was assigned to explore changes in cholesterol levels following nonsurgical periodontal therapy in patients with chronic periodontitis. Materials and methods:Periodontal parameters and lipid profile (total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides and very low-density lipoprotein) were evaluated in 50 subjects suffering from moderate to severe generalized chronic periodontitis.Results: At third month, there was significant reduction in total cholesterol, low density lipoprotein, very low density lipoprotein, triglyceride and increase in high density lipoprotein after nonsurgical periodontal therapy (NSPT). Also, the reduction in bleeding on probing, pocket depth and attachment level were statistically significant in the treatment group. Conclusion:The results of our study showed that periodontal destruction and serum lipid levels are positively correlated and nonsurgical periodontal treatment in chronic periodontitis patients resulted in significant changes in the concentration of total cholesterol, triglycerides, HDL, LDL levels in blood serum.

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“…It should be highlighted that recent cross-sectional studies, which investigated the relationship between periodontal disease and serum lipid have obtained similar findings to the present study. 32,33 Previous study reported that chronic inflammation in periodontal tissue significantly correlated with TC and LDL, while it showed no relationship with TG and HDL. Greater loss of attachment >3 mm was reported previously to have 1.31 times greater in intima-media wall thickness as pre-atherosclerotic condition.…”

Section: Discussionmentioning

confidence: 99%

The Association between Periodontal Conditions and Serum Lipids among Elderly Participants in Gadjah Mada Medical Centre, Yogyakarta

Widita¹,

Hanindriyo²,

Widyaningrum³

et al. 2017

J Dent Indones

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Prevention of cardiovascular diseases by controlling risk factors at an early stage is very important. Objective: To determine the relationship between periodontal conditions with serum lipids among the elderly. Methods: Total of 78 participants (56 males and 32 females) who were in the age range of 60-76 years were selected for the current study. A logistic regression analysis was used to evaluate the association between periodontal conditions and serum lipid profile. Periodontal conditions was recorded as the maximum score of pocket depth (PD) and loss of attachment (LoA) score which presented in the participants, while levels of total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and triglycerides (TG) were measured for the serum lipids profile. Age, gender, BMI, high blood pressure, pattern of dental visit, hypertension and cholesterol medication, number of teeth, PD, and LoA were included in the model as independent variable. TC, HDL, LDL, and TG were used as dependent variables. Results: According to the results of the logistic regression analysis, loss of attachment >6 mm was associated with TC (p<0.01;, while PD had no association with serum lipids (p>0.05). Conclusion: This study indicates that subjects with greater loss of attachment significantly associated with higher levels of serum TC and LDL. This may suggest that elderly people with greater loss of attachment are potentially at risk of having serum lipid impairment.

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Lipoprotein‐associated phospholipase A₂ and plasma lipids in patients with destructive periodontal disease

Abstract: This study indicates that treatment of periodontitis significantly reduces the serum activity of Lp-PLA(2), which is believed to be an independent cardiovascular risk factor.

Cited by 59 publications

References 40 publications

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Evaluation of Alteration in Serum Lipid Levels in Patients with Chronic Periodontitis Postperiodontal Therapy

The Association between Periodontal Conditions and Serum Lipids among Elderly Participants in Gadjah Mada Medical Centre, Yogyakarta

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Lipoprotein‐associated phospholipase A2 and plasma lipids in patients with destructive periodontal disease

Abstract: This study indicates that treatment of periodontitis significantly reduces the serum activity of Lp-PLA(2), which is believed to be an independent cardiovascular risk factor.

Cited by 59 publications

References 40 publications

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Evidence that periodontal treatment improves biomarkers and CVD outcomes

Evaluation of Alteration in Serum Lipid Levels in Patients with Chronic Periodontitis Postperiodontal Therapy

The Association between Periodontal Conditions and Serum Lipids among Elderly Participants in Gadjah Mada Medical Centre, Yogyakarta

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Lipoprotein‐associated phospholipase A₂ and plasma lipids in patients with destructive periodontal disease