Lipoprotein apheresis: an update

Julius, Ulrich; Schatz, Ulrike; Hohenstein, Bernd; Bornstein, Stefan R.

doi:10.2217/clp.13.68

Cited by 30 publications

(22 citation statements)

References 86 publications

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“…All patients met the official German criteria of an indication for the treatment with LA, e. g. they suffered from a severe hypercholesterolemia and/or an elevation of lipoprotein(a) which led to cardiovascular events [12]. Apheresis sessions were performed weekly.…”

Section: Methodsmentioning

confidence: 99%

“…Table 1 shows the methods and the number of patients treated with them. Details of these methods have been recently summarized [12]. In the mean the following volumes were processed during the apheresis sessions:…”

Section: Methodsmentioning

confidence: 99%

“…We are the only center in Germany using all widely available LA methods [11,12]. Herein we compare these methods with respect to their protein lowering effect by measuring protein concentrations before and after one single apheresis session.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of different lipoprotein apheresis methods on serum protein levels

Julius

Siegert

Kostka

et al. 2015

Atherosclerosis Supplements

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Effects of different lipoprotein apheresis methods on serum protein levels

Julius

Siegert

Kostka

et al. 2015

Atherosclerosis Supplements

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“…The six LA methods used in Dresden are based on different techniques (precipitation, filtration and adsorption) [11]. …”

Section: Lipoprotein Apheresis (La) Immunoadsorption (Ia) and Rheophmentioning

confidence: 99%

Adverse events of lipoprotein apheresis and immunoadsorption at the Apheresis Center at the University Hospital Dresden

Dittrich-Riediger

Schatz

Hohenstein

et al. 2015

Atherosclerosis Supplements

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“…A register of existing providers of Lp apheresis is kept by HEART UK [68]. Commercial systems have similar effectiveness and their technical specifications have been reviewed recently [65,66,69]. In HoFH, 1e2 plasma volumes need to be treated ideally at weekly intervals.…”

Section: Lp Apheresismentioning

confidence: 99%

HEART UK statement on the management of homozygous familial hypercholesterolaemia in the United Kingdom

et al. 2016

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This consensus statement addresses the current three main modalities of treatment of homozygous familial hypercholesterolaemia (HoFH): pharmacotherapy, lipoprotein (Lp) apheresis and liver transplantation. HoFH may cause very premature atheromatous arterial disease and death, despite treatment with Lp apheresis combined with statin, ezetimibe and bile acid sequestrants. Two new classes of drug, effective in lowering cholesterol in HoFH, are now licensed in the United Kingdom. Lomitapide is restricted to use in HoFH but, may cause fatty liver and is very expensive. PCSK9 inhibitors are quite effective in receptor defective HoFH, are safe and are less expensive. Lower treatment targets for lipid lowering in HoFH, in line with those for the general FH population, have been proposed to improve cardiovascular outcomes. HEART UK presents a strategy combining Lp apheresis with pharmacological treatment to achieve these targets in the United Kingdom (UK). Improved provision of Lp apheresis by use of existing infrastructure for extracorporeal treatments such as renal dialysis is promoted. The clinical management of adults and children with HoFH including advice on pregnancy and contraception are addressed. A premise of the HEART UK strategy is that the risk of early use of drug treatments beyond their licensed age restriction may be balanced against risks of liver transplantation or ineffective treatment in severely affected patients. This may be of interest beyond the UK.

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Lipoprotein apheresis: an update

Cited by 30 publications

References 86 publications

Effects of different lipoprotein apheresis methods on serum protein levels

Effects of different lipoprotein apheresis methods on serum protein levels

Adverse events of lipoprotein apheresis and immunoadsorption at the Apheresis Center at the University Hospital Dresden

HEART UK statement on the management of homozygous familial hypercholesterolaemia in the United Kingdom

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