Effects of different lipoprotein apheresis methods on serum protein levels

Julius, Ulrich; Siegert, Gabriele; Kostka, H.; Schatz, Ulrike; Hohenstein, Bernd

doi:10.1016/j.atherosclerosissup.2015.02.018

Cited by 33 publications

(19 citation statements)

References 21 publications

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“…Our study also found that immunoglobulins A, G, and M were reduced by 14%, 20%, and 44%, respectively. Julius and coworkers reported similar results that a single LA treatment had an effect on lowering immunoglobulin concentrations, especially IgM . However, the concentrations of hsCRP were not influenced significantly by LA treatment in our study, which was inconsistent with previous results .…”

Section: Discussioncontrasting

confidence: 99%

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

Wen

Dong

et al. 2019

Clinical Laboratory Analysis

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Background and aims: Familial hypercholesterolemia (FH) characterized by severe high blood cholesterol levels usually presents an imbalance of systemic oxidative stress(OS).Lipoproteinapheresis(LA),whichisthemosteffectivetherapytoreduce cholesterollevels,remainsunclearinalteringOSandscarceinChinesepatientstudies. OurstudyaimstoassesstheimpactofLAonOSstatusinChinesepatientswithFH.Methods: About31patients(22males,age:12-69years)withFHandreceivingLA treatment were consecutive enrolled. Free oxygen radicals test (FORT) and free oxygen radicals defense (FORD) values were determined using the free oxygen radical monitor and kit immediately before and after LA, while blood samples were collected to measure plasma lipid levels and hs-CRP by conventional methods. Data were analyzed by paired ttestorranksumtestandSpearman-rhocorrelationanalysis.Results: Besides plasma lipid levels, the OS status showed that FORTs were significantly decreased and FORD values significantly enhanced immediately after LA treatment compared with before (both P < .01). In addition, the correlation analysis showed that the removal rates (△%) of TC were positively related to the increased rates (△%) of FORD value (ρ = 0.513, P = .003); LDL-C to FORD (ρ = 0.39, P = .03); Lp(a) to FORD (ρ=0.473,P=.007);andnon-HDL-CtoFORD(ρ = 0.46, P = .009). However,nosignificantdifferenceinhsCRPwasfound.Conclusions: The present study indicated, besides effectively lowering plasma lipid levels,LAcouldsignificantlyimproveOSstatusinChinesepatientswithFH. K E Y W O R D S familial hypercholesterolemia, lipoprotein apheresis, oxidative stressThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussioncontrasting

confidence: 99%

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

Wen

Dong

et al. 2019

Clinical Laboratory Analysis

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“…Serum ferritin levels were reduced by 10%e30 %, depending on the LA method. Highest reduction rates were observed with lipidfiltration methods (MONET and MDF) [14]. This present study shows that the range of serum ferritin reduction lies more realistically between 14% and 18%, with the lowest reduction found with HELP and DALI methods.…”

Section: Discussionmentioning

confidence: 60%

TIDILAP: Treatment of iron deficiency in lipoprotein apheresis patients – A prospective observational multi-center cohort study comparing efficacy, safety and tolerability of ferric gluconate with ferric carboxymaltose

Schatz

Illigens

Siepmann

et al. 2015

Atherosclerosis Supplements

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“…All so-called specific LA methods exert an impact on other (besides lipoproteins) protein concentrations. 41 HELP and filtration methods effectively decrease fibrinogen concentrations. The slightest impact on total serum protein and on albumin was observed with the whole blood methods.…”

Section: Safety Tolerability and Follow-upmentioning

confidence: 98%

Lipoprotein apheresis in the management of severe hypercholesterolemia and of elevation of lipoprotein(a): current perspectives and patient selection

Julius¹

2016

MDER

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This review reports the current situation with respect to therapeutic options (lifestyle and drugs) reducing the concentrations of atherogenic low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]). Three lipoprotein apheresis (LA) principles have been realized: precipitation, filtration, and adsorption. Available LA methods are herein described in detail – major components, pumps, extracorporeal volume, treated volume, and anticoagulation. General features of all LA methods as well as pleotropic effects are elaborated. Indications for LA therapy are quoted: homozygous familial hypercholesterolemia (HCH), severe HCH, and isolated elevation of Lp(a) and progress of atherosclerotic disease. A major focus is on the evidence of the effect of LA on cardiovascular outcome data, and the most important publications are cited in this context. The best studies have been performed in patients with elevated Lp(a) in whom cardiovascular events were reduced by more than 80%. Major adverse effects and contraindications are listed. The impact of an LA therapy on patient quality of life and the requirements they have to fulfill are also highlighted. Finally, the future role of LA in treating high-risk patients with high LDL-C and/or high Lp(a) is discussed. It is probable that the significance of LA for treating patients with elevated LDL-C will decrease (with the exception of homozygous familial HCH) due to the application of PCSK9 inhibitors. The antisense oligonucleotide against apolipoprotein(a) could replace LA in patients with high Lp(a), provided positive outcome data are generated.

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Effects of different lipoprotein apheresis methods on serum protein levels

Cited by 33 publications

References 21 publications

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

TIDILAP: Treatment of iron deficiency in lipoprotein apheresis patients – A prospective observational multi-center cohort study comparing efficacy, safety and tolerability of ferric gluconate with ferric carboxymaltose

Lipoprotein apheresis in the management of severe hypercholesterolemia and of elevation of lipoprotein(a): current perspectives and patient selection

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