Lipoprotein alterations in liver cirrhosis: a possible contribution to changes in plasma oncotic pressure and viscosity

Matas, Carme; Joven, Jorge; Vilella, Elisabet; Clivillé, X; Cabré, María; Prats, E; Camps, Jordi

doi:10.1016/s0168-8278(97)80080-3

Cited by 9 publications

(2 citation statements)

References 25 publications

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“…Regarding the drug disposition, a change in protein binding for a low‐extraction drug like octreotide is only considered important if the ‘normal’ protein binding exceeds 85% 34 . Hence, the reduced protein binding expected in the cirrhotic patients due to altered chemistry and reduced concentration of lipoproteins, 35 as well as reduced albumin, is probably of minor importance to the pharmacokinetics of octreotide. Further clinical studies are needed to elucidate the consequences of reduced protein binding of octreotide in cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

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The organ extraction and splanchnic haemodynamic effects of octreotide in cirrhotic patients

Ottesen

Flyvbjerg

Möller

et al. 1998

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

“…Results: The extraction fraction of octreotide in the liver was 0.05 (A 0.01±0.14) (median (interquartile range)) and in the kidneys 0.16 (A 0.06±0. 35). The extraction fraction ratio (E liver /E kidney ) was 0.69 (A 0.20±1.06).…”

Section: Introductionmentioning

confidence: 99%

The organ extraction and splanchnic haemodynamic effects of octreotide in cirrhotic patients

Ottesen

Flyvbjerg

Möller

et al. 1998

Aliment Pharmacol Ther

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Expression of apolipoprotein AI mRNA in peripheral white blood cells of patients with alcoholic liver disease

Nuño-González

Ruíz-Madrigal

Bastidas-Ramírez

et al. 2005

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Because (i) changes in plasma and liver mRNA of apolipoprotein (apo) AI have been observed in patients with alcoholic liver disease, (ii) apo AI mRNA can be induced in non-hepatic tissues, and (iii) apolipoproteins expression is influenced by plasma colloid osmotic pressure (P(CO)) and viscosity (eta), we analyzed the Apo AI mRNA expression in the peripheral white blood cells (PWBC), P(CO), and eta in control volunteers (C), patients with liver cirrhosis (LC), and cirrhotic patients with superimposed alcoholic hepatitis (LC+AH). We found that apo AI mRNA is expressed in the PWBC in 20% of C and it is induced 1.5 fold in 66.6% of LC and 1.95 fold in 85% of LC+AH. A significant decrease of P(CO) in LC and LC + AH (14.8 +/- 2.4 and 16.2 +/- 2.4 mm Hg, respectively) compared to C (27.9 +/- 2 mm Hg) was observed. By contrast, eta was mildly increased from 1.7389 +/- 0.07 in C to 1.8022 +/- 0.154 in LC and 1.9030 +/- 0.177 in LC+AH. No significant correlation was found between P(CO) and eta with apo AI mRNA but with lipid profile. In conclusion, apo AI mRNA expression in PWBC is associated to liver disease severity and could be an indirect indicator of alcoholic liver damage.

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Plasma phospholipid fatty acid pattern in severe liver disease

Clemmesen

Høy

Jeppesen

et al. 2000

Journal of Hepatology

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Lipoprotein alterations in liver cirrhosis: a possible contribution to changes in plasma oncotic pressure and viscosity

Cited by 9 publications

References 25 publications

The organ extraction and splanchnic haemodynamic effects of octreotide in cirrhotic patients

The organ extraction and splanchnic haemodynamic effects of octreotide in cirrhotic patients

Expression of apolipoprotein AI mRNA in peripheral white blood cells of patients with alcoholic liver disease

Plasma phospholipid fatty acid pattern in severe liver disease

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