To compare the lipoprotein (a) level in type II diabetics and non diabetics with acute coronary syndrome. Materials and Methods: A total of 80 subjects including 40 patients with type II diabetes as cases and 40 non diabetics as control admitted in ICU matched for age and sex included in the study. Serum FBS, TG, cholesterol, LDL, HDL and serum Lp (a) in both the groups were measured. Statistical analysis was performed using SPSS software. Results: Lp (a) level was significantly higher (p< 0.001) in diabetics as compared to control group. Conclusion: Study concluded that increased serum Lp(a) concentration might be a risk factor in type II diabetic patients for coronary artery disease.