Lipoprotein(a) levels in relation to diabetic complications in patients with non‐insuIin‐dependent diabetes

Heesen, B J; Wolffenbuttel, Bruce H. R.; Leurs, Paul; Sels, J. P. J. E.; Menheere, P. P. C. A.; Jäckle-Beckers, S. E. C.; Kruseman, A. C. Nieuwenhuijzen

doi:10.1111/j.1365-2362.1993.tb00969.x

Cited by 36 publications

(14 citation statements)

References 39 publications

(36 reference statements)

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“…These findings were confirmed by Joven and Viella (18) and Hessen et al (19). The mechanism by which Lp(a) levels in diabetes are increased is unclear, however.…”

Section: Results -Anthropometric and Metabolic Characteristics Of Thesupporting

confidence: 86%

Lipoprotein(a) in Android Obesity and NIDDM

et al. 1997

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“…These findings were confirmed by Joven and Viella (18) and Hessen et al (19). The mechanism by which Lp(a) levels in diabetes are increased is unclear, however.…”

Section: Results -Anthropometric and Metabolic Characteristics Of Thesupporting

confidence: 86%

Lipoprotein(a) in Android Obesity and NIDDM

et al. 1997

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“…However, there has been little prior evidence (14-17) of a link between CHD and lipoprotein(a) in diabetes, although lipoprotein(a) was elevated in NIDDM subjects with a history of myocardial infarction (18), and others (19,20) have shown that higher levels are associated with a higher prevalence of CHD in NIDDM patients.…”

Section: Resultsmentioning

confidence: 94%

Serum Sialic Acid Concentration and Coronary Heart Disease in NIDDM

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Mattock²,

Crook³

et al. 1995

Diabetes Care

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OBJECTIVE--To examine the association between serum sialic acid concentrations and coronary heart disease (CHD) in a cross-sectional study of non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS--NIDDM patients (n = 145) attending a diabetic clinic were studied. CHD status was assessed by questionnaire and electrocardiogram coding, and potential risk factor assessment included measurement of fasting serum lipid and lipoprotein concentrations, blood pressure, and urinary albumin excretion rate (AER). RESULTS--Male NIDDM patients with CHD had a higher serum sialic acid level than those without CHD: 2.56 (2.24, 2.72) mmol/l vs. 2.24 (2.18, 2.30) mmol/l, P = 0.01, mean (95% confidence interval). They were also older, had a longer duration of diabetes, had a higher AER, had higher total triglyceride, very-low-density lipoprotein triglyceride and cholesterol, and lipoprotein(a) concentrations, and had a lower apolipoprotein A1 concentration. In an age adjusted multiple lipoprotein(a), hypercholesterolemia, and hypertension were associated with CHD. In women, only hypertension treatment was associated with CHD. CONCLUSIONS--There is a strong univariate association between elevated serum sialic acid and CHD in men (but not women) with NIDDM.

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“…On the contrary, other studies in Japan (8,9) (14) reported that serum apo(a) levels were raised in active diabetic retinopathy groups (severe NPDR or PDR) compared with no diabetic retinopathy group. Hessen et al (15) also reported higher prevalence of preproliferative retinopathy with increasing Lp(a) levels in type 2 diabetic patients. On the other hand, in Japanese studies (8,9), there were no significant differences between the patients with NPDR and those with PDR.…”

Section: Conclusion-this Cross Secmentioning

confidence: 90%