Lipoprotein(a) in Android Obesity and NIDDM

Wassef, Nabila M.; Sidhom, Gloria; el-K, Zakareya; el-K, Mohamed

doi:10.2337/diacare.20.11.1693

Cited by 16 publications

(10 citation statements)

References 17 publications

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“…Cross-sectional studies of adults have not consistently shown a relationship of Lp(a) with NIDDM. Conversely, several reports indicate an association between IDDM with Lp(a) [29,41]. However, NIDDM is thought to have a stronger genetic component in its etiology than IDDM [42].…”

Section: Discussionmentioning

confidence: 99%

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et al. 2004

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ObjectiveTo determine the correlates of serum lipoprotein (a) (Lp(a)) in children and adolescents in the United States.MethodsCross-sectional study using representative data from a US national sample for persons aged 4–19 years participating in The Third National Health Nutrition and Examination Survey (NHANES-III).ResultsWe observed ethnicity-related differences in levels of Lp(a) > 30 mg/dl, with values being markedly higher in African American (black) than nonhispanic white (white) and Mexican American children in multivariate model (P < 0.001). Higher levels of Lp(a) > 30 mg/dl associated with parental history of body mass index and residence in metro compared to nonmetro in Blacks, and high birth weight in Mexican American children in the NHANES-III. In the entire group, total cholesterol (which included Lp(a)) and parental history of premature heart attack/angina before age 50 (P < 0.02) showed consistent, independent, positive association with Lp(a). In subgroup analysis, this association was only evident in white (P = 0.04) and black (P = 0.05) children. However, no such collective consistent associations of Lp(a) were found with age, gender, or birth weight.ConclusionEthnicity-related differences in mean Lp(a) exist among children and adolescents in the United States and parental history of premature heart attack/angina significantly associated with levels of Lp(a) in children. Further research on the associations of Lp(a) levels in childhood with subsequent risk of atherosclerosis is needed.

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Section: Discussionmentioning

confidence: 99%

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et al. 2004

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“…Elevated levels of serum Lp(a) is also associated with an increased risk of coronary heart disease in patients with diabetes [13,14]. It is also a predictor of non-proliferative retinopathy in these patients [15][16][17][18][19]. Lp(a) is present in the arterial wall at sites of atherosclerosis in humans and results in both atherogenesis and thrombosis (3).…”

Section: Introductionmentioning

confidence: 99%

Serum Lipoprotein(a) Levels are Greater in Female than Male Patients with Type‐2 Diabetes

Nakhjavani¹,

Morteza²,

Esteghamati³

et al. 2010

Lipids

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Women with diabetes are faced with a higher risk of dyslipidemia and cardiovascular disorders than men with diabetes. We aimed to study the role of gender and menopausal status in serum Lp(a) levels in patients with type 2 diabetes. We quantified serum Lp(a) levels in a group of 477 patients with type 2 diabetes (men, premenopausal and postmenopausal women with diabetes), as well as in 105 controls. We stratified the patients into two groups of low Lp(a) levels (Lp(a) <35 mg/dl) and elevated Lp(a) levels (Lp(a) >35 mg/dl). Patients with diabetes had higher serum Lp(a) levels than the controls. Serum Lp(a) levels was significantly higher in women with diabetes than men with diabetes. Lp(a) levels did not differ between male and females in the control group. Premenopausal and postmenopausal women with diabetes did not differ significantly in serum Lp(a) levels. The odds ratio of having a serum Lp(a) level higher than 35 was 5.85 in premenopausal women with diabetes, 5.08 in postmenopausal women with diabetes, 2.41 in men with diabetes and 1.9 in the women in the control group compared to the men in the control group, after adjustment for age and BMI. This observational study clearly indicated that serum Lp(a) levels were significantly higher in women and men with diabetes. The increase in women was independent of menopause. The level of serum Lp(a) had no correlation with lipid parameters in men or women.

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“…Lp(a) is recognized as a new coronary risk factor, but few studies have quantitatively assessed the relationship of serum Lp(a) levels with other coronary risk factors in many patients undergoing coronary cineangiography. Among many coronary risk factors that were quantified (i.e., age, gender, hypertension, impaired glucose tolerance, cerebrovascular accident, hyperuricemia, smoking, family history of ischemic heart disease (IHD), history of hyperlipidemia, Lp(a), total cholesterol, high density lipoprotein (HDL)-cholesterol, triglyceride, low density lipoprotein-cho-lesterol, apo A-I,B, E), Lp(a) is an independent, potential, and modifiable coronary risk factor, and its reduction is important in the clinical management of patients with ischemic heart disease and stroke [8][9][10][11] . Newer risk factors were described, including homocysteine and chronic infection (Chlamydia pneumoniae and periodontal disease), are being studied as predictors of ischemic stroke.…”

Section: Resultsmentioning

confidence: 99%

“…Prospective studies that evaluated Lp(a) as a predictor of cardiovascular and cerebrovascular events in men have had conflicting results . Some studies suggested that Lp(a) was an independent risk factor for coronary heart disease (CHD), while others showed no significant association [6][7][8][9][10][11][12] . Strokes are one of the most common causes of mortality and long term severe disability.…”

mentioning

confidence: 99%

Plasma lipoprotein(a) levels: a comparison between diabetic and non-diabetic patients with acute ischemic stroke

Holanda

Filizola

Costa

et al. 2004

Arq. Neuro-Psiquiatr.

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-Objective: The aim of this study was to evaluate lipoprotein(a) (Lp(a)), total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), very low density lipoprotein cholesterol (VLDL ), triglycerides , apolipoprotein A (apo A) and B100 (apo B100), uric acid, glycaemic and insulin plasmatic concentrations in patients affected by acute stroke. In this group of patients, we have compared the variables between type 2 diabetic patients and non-diabetic patients. Method: We evaluate a total of 34 non-diabetic patients (22 males and 12 females; mean age 66.71 ± 10.83 years) and a group of 26 type 2 diabetic patients (15 males and 11 females; mean age 66.35 ± 9.92 years) in a cross-sectional study. Results: Mean Lp(a) concentration did not significantly differ between type 2 diabetic patients and non-diabetic subjects (29.49 ± 23.09 vs 44.81 ± 44.34 mg/dl). The distribution of Lp(a)levels was highly skewed towards the higher levels in both groups, being over 30 mg/dl in 50%. Lp(a) concentration was positively correlated with abdominal adiposity, using waist-hip ratio(WHR)(p< 0.05). No association was found between Lp(a) and others risk factors like sex, age, other lipidic parameters and the presence of stroke. Conclusions: Our results showed that there were no significant differences between diabetic and non-diabetic patients` serum Lp(a) levels, which indicates that elevated Lp(a) levels were associated with ischemic stroke, irrespective of the presence of type 2 diabetes mellitus (type 2 DM).KEY WORDS: lipoprotein(a), stroke, type II diabetes.Níveis plasmáticos de lipoproteína(a): uma comparação entre pacientes diabéticos e não-diabéticos com acidente vascular cerebral isquêmico agudo RESUMO -Objetivo: O objetivo deste estudo foi avaliar os níveis de lipoproteína(a) (Lp(a)), colesterol total, lipoproteína de alta densidade (HDL), lipoproteína de baixa densidade (LDL), lipoproteína de muito baixa densidade (VLDL), triglicerídeos, apolipoproteína A (apo A) e B100 ( apo B100), ácido úrico e concentrações plasmáticas de insulina e glicose em pacientes acometidos por acidente vascular cerebral isquêmico. Neste grupo de pacientes, comparamos as variáveis entre diabéticos tipo 2 e pacientes não-diabéticos. Método: Nós avaliamos um total de 34 pacientes não-diabéticos (22 homens e 12 mulheres, com idade média 66,71±10,83 anos) e um grupo de 26 pacientes diabéticos tipo 2 (15 homens e 11 mulheres, com idade média 66,35±9,92 anos) em um estudo transversal. Resultados: A concentração média de Lp(a) não variou significativamente entre os pacientes diabéti-cos tipo 2 e os não-diabéticos (29,49±23,09 vs 44,81±44,34 mg/dl). A distribuição dos níveis de Lp(a) foi altamente convergente em direção aos níveis mais altos em ambos os grupos, estando maior que 30mg/dl em 50%. A concentração de Lp(a) foi positivamente correlacionada com a adiposidade abdominal, usando a relação cintura-quadril (RAQ) (P<0,05). Nenhuma associação foi encontrada entre Lp(a) e outros fatores de risco, como se...

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Lipoprotein(a) in Android Obesity and NIDDM

Abstract: Lp(a) levels are significantly elevated in both android-obese and nonobese NIDDM patients regardless of the degree of glycemic control. Lp(a) is an independent risk factor showing greater elevations in those subjects complicated with diabetic vascular diseases.

Cited by 16 publications

References 17 publications

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Serum Lipoprotein(a) Levels are Greater in Female than Male Patients with Type‐2 Diabetes

Plasma lipoprotein(a) levels: a comparison between diabetic and non-diabetic patients with acute ischemic stroke

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