Lipoprotein(a) levels and atherosclerotic plaque characteristics in the carotid artery: The Plaque at RISK (PARISK) study

Abstract

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Carotid Plaque Composition and the Importance of Non-Invasive in Imaging Stroke Prevention

“…In women, elevated plasma Lp(a) levels were associated with higher prevalence of IPH and in men, elevated Lp(a) levels were associated with a higher degree of stenosis. The association between Lp(a) concentration and these vulnerable plaque characteristics supports the hypothesis that Lp(a) has a role in the process of atherosclerosis ( 56 ).…”

Differential associations of lipoprotein(a) level with cerebral large artery and small vessel diseases

“…Lp(a) has shown to be proinflammatory, proatherogenic, prothrombotic, and antifibrinolytic potential, and promote atherosclerosis 6. Recent studies demonstrated that elevated (Lp(a)) concentrations was correlated to greater degree of carotid artery stenosis and plaque progression 12 13. Our study further demonstrated that elevated Lp(a) was associated with high odds of presence and burden of intracranial atherosclerosis.…”

“…Lp(a) was shown to be proatherogenic and may promote atherosclerotic cardiovascular diseases 7–11. Previous studies also have demonstrated that high Lp(a) level was related to carotid atherosclerosis,12 13 atherothrombotic stroke14 and ischaemic stroke 7 8 15 16. In contrast, few study investigated the association of Lp(a) level with cerebral small vessel diseases (cSVD).…”

The Effects of Menopause Hormone Therapy on Lipid Profile in Postmenopausal Women: A Systematic Review and Meta-Analysis

“…Our systematic review indicated that compared with placebo or no treatment, MHT could significantly decrease the concentrations of TC, LDL-C, and Lp (a). Lp(a) is an independent risk factor for CVD and recurrent ischemic stroke ( Nordestgaard et al, 2010 ), the previous study showed the similar result of MHT on Lp(a) with us ( van Dam-Nolen et al, 2021 ). As for the TG concentration, previous study had showed that MHT could significantly increase it ( Stevenson et al, 2015 ).…”