Lipoprotein(a) Is Associated with the Presence and Severity of New-Onset Coronary Artery Disease in Postmenopausal Women

Yan, Xiao-Ni; Jin, Jing‐Lu; Liu, Hong; Guo, Yuan‐Lin; Wu, Na‐Qiong; Zhu, Cheng‐Gang; Dong, Qian; Li, Jianjun

doi:10.1089/jwh.2019.7773

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…Many studies have shown that Lp(a) levels may increase slightly in the perimenopausal period. Although studies are still inconsistent, it cannot be excluded that an elevated Lp(a) concentration may increase the incidence of coronary artery disease in postmenopausal women [ 48 ].…”

Section: Lipid Disordersmentioning

confidence: 99%

Menopause and women’s cardiovascular health: is it really an obvious relationship?

et al. 2022

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Cardiovascular diseases are common for women and men but there are differences between the sexes in terms of clinical symptoms, pathophysiology and response to the treatment. CVD in women is commonly underdiagnosed and often women tend to have a lower perception of the risk. That can lead to delayed diagnosis and failed recognition of symptoms. Women develop heart disease later than men because of the protection that exists in the reproductive phase of their life. Once they enter menopause the risk increases. Estrogen provides a protective effect against heart disease in women. Therefore, the risk of CVD increases after menopause in most cases. Presented work emphasizes the importance of the menopausal period as the time of increasing CVD risk. Emphasize the importance of monitoring the health of women in their middle age, a critical time in which early intervention strategies should be implemented to reduce the risk of CVD.

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Section: Lipid Disordersmentioning

confidence: 99%

Menopause and women’s cardiovascular health: is it really an obvious relationship?

et al. 2022

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“…[20] Other research supports that Lp(a) is an independent risk factor for predicting the presence and severity of new-onset CVD in postmenopausal Chinese women. [21] In summary, elevated Lp(a) levels may be affected by many distinct factors and the distribution of Lp(a) alleles is different in the Chinese population compared to Western populations. As a whole, the Chinese population has lower plasma Lp(a) levels compared with that in Western populations.…”

Section: Epidemiological Studies Of Lp(a) In the Chinese Populationmentioning

confidence: 95%

“…[20] Other research supports that Lp(a) is an independent risk factor for predicting the presence and severity of new-onset CVD in postmenopausal Chinese women. [21]…”

Section: Background Knowledge Of Lp(a)mentioning

confidence: 99%

Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese Population

2022

Cardiology Discovery

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Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Multiple factors are involved in CVD, and emerging data indicate that lipoprotein(a) (Lp(a)) may be associated with atherosclerotic cardiovascular disease (ASCVD) independent of other traditional risk factors. Lp(a) has been identified as a novel therapeutic target. Previous studies on the influence of Lp(a) in CVD have mainly used in western populations. In this review, the association of plasma Lp(a) concentration with ASCVD was summarized, with regards to epidemiological, population-based observational, and pathological studies in Chinese populations. Lp(a) mutations and copy number variations in Chinese populations are also explored. Finally, the impact of plasma Lp(a) levels on patients with type 2 diabetes mellitus, cancer, and familial hypercholesterolemia are discussed.

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“…But the routine lipid panel, lack of lipoprotein a (Lp(a)) and particles of lipoprotein, is not efficiency in ASCVD prevention, especially for postmenopausal women. It had been reported that Lp(a), which couldn't distinguish from LDL-C in routine lipid panel, was an independent risk factor for the presence and severity of new-onset coronary atherosclerotic disease (CAD) in postmenopausal women [10]. A series studies on the characteristics of HDL subgroups in postmenopausal women revealed that smaller HDL size and lower total and medium HDL particles (HDL-p) were associated with incident CVD, whereas lower large HDL-p was associated with extent of coronary calcification [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Particles and corrected particles of LDL and non-HDL are stronger predicters of coronary lesion in postmenopausal women

Chen

Wei

et al. 2021

BMC Cardiovasc Disord

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Background The optimum lipid indexes, predicting the coronary lesion in postmenopausal women are not clear. Objective To evaluate the optimum lipid predicter for coronary lesion in routine and advanced lipid tests. Method 300 postmenopausal women were enrolled and assigned into coronary heart disease (CHD) Group (242), and non-CHD Group (58). Routine and advanced lipid indexes were measured with standard laboratory test and nuclear magnetic resonance (NMR) spectroscopy. The correlation and predictivities for CHD of routine and advanced lipid indexes were performed with Logistic regression, Spearman correlation analysis and receiver operating characteristic (ROC). Results Age (hazard ratio (HR) 2.58, 95% confidence interval (CI) 1.08–5.86, P = 0.03), apolipoprotein B (ApoB) (HR 1.35, 95% CI 1.15–1.59, P < 0.001), corrected particles of low-density lipoprotein (LDL-p-corr) (HR 1.05, 95% CI 1.03–1.06, P < 0.001) and corrected particles of non-high-density lipoprotein (non-HDL-p-corr) (HR 1.02, 95% CI 1.01–1.03, P < 0.001) were the risk factors of CHD. LDL cholesterol (LDL-C), LDL-p, LDL-p-corr, HDL cholesterol (HDL-C), non-HDL cholesterol (non-HDL-C), non-HDL-p and non-HDL-p-corr were in linear correlation with Gensini score. Advanced lipid indexes LDL-p (area under curve (AUC) = 0.750, P = 0.02), LDL-p-corr (AUC = 0.759, P = 0.02), non-HDL-p (AUC = 0.693, P = 0.03) and non-HDL-p-corr (AUC = 0.699, P = 0.03) were more predictive for CHD than the routine ones (LDL-C and non-HDL-C). Conclusion In postmenopausal women, age, ApoB, LDL-p-corr and non-HDL-p-corr were risk factors of CHD. Compared with traditional lipid items, LDL-p, LDL-p-corr, non-HDL-p and non-HDL-p-corr may be better lipid indexes for CHD in postmenopausal women.

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Lipoprotein(a) Is Associated with the Presence and Severity of New-Onset Coronary Artery Disease in Postmenopausal Women

Cited by 8 publications

References 27 publications

Menopause and women’s cardiovascular health: is it really an obvious relationship?

Menopause and women’s cardiovascular health: is it really an obvious relationship?

Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese Population

Particles and corrected particles of LDL and non-HDL are stronger predicters of coronary lesion in postmenopausal women

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