Lipopolysaccharide-Mediated Mast Cell Activation Induces IFN-γ Secretion by NK Cells

Vosskuhl, Katja; Greten, Tim F.; Manns, Michael P.; Korangy, Firouzeh; Wedemeyer, Jochen

doi:10.4049/jimmunol.0902406

Cited by 35 publications

(28 citation statements)

References 59 publications

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“…MC interaction with NK cells during inflammation may extend beyond their recruitment. For example, LPS or CpG-activated MCs physically interact with NK cells to promote enhanced IFN production that is contact and TNF-dependent (59) , suggesting that the physical interactions between MCs and NK cells that have been observed during viral infection within tissues (15) may be sites where this type of communication occurs.…”

Section: Modulation Of Innate Responses To Pathogensmentioning

confidence: 99%

Innate Immunity and Its Regulation by Mast Cells

John

Abraham

2013

The Journal of Immunology

178

135

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Mast cells (MCs), granulated tissue-resident cells of hematopoietic lineage, constitute a major sensory arm of the innate immune system. This review discusses the evidence supporting the dual role of MCs, both as sentinels for invading pathogens, as well as regulatory cells throughout the course of acute inflammation, from its initiation to resolution. This versatility is dependent on the MC’s ability to detect pathogens and danger signals and release a unique panel of mediators to promote pathogen-specific clearance mechanisms, such as through cellular recruitment or vascular permeability. It is increasingly understood that MCs also contribute to the regulated contraction of immune activation that occurs within tissues as inflammation resolves. This overarching regulatory control over innate immune processes has made MCs successful targets to purposefully enhance or, alternatively, suppress MC responses in multiple therapeutic contexts.

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Section: Modulation Of Innate Responses To Pathogensmentioning

confidence: 99%

Innate Immunity and Its Regulation by Mast Cells

John

Abraham

2013

The Journal of Immunology

178

135

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“…Lipopolysaccharide (LPS)-activated BMMCs induce cell contact-dependent IFN-γ secretion by NK cells, without affecting cell-mediated cytotoxicity. Cellular interaction is partly mediated by OX40L expression on MCs (Vosskuhl et al, 2010). In the cited work, authors underline that different MC signals of activation confer different results in terms of NK activation.…”

Section: Pattern Of MC Membrane-bound Molecules Regulating Immunologimentioning

confidence: 99%

“…In the cited work, authors underline that different MC signals of activation confer different results in terms of NK activation. In fact, in addition to LPS, stimulation of MCs via TLR3 and TLR9, but not with IgE/antigen, amplifies IFN-γ secretion by NK cells (Vosskuhl et al, 2010). Similarly, in a model of hepatocarcinoma, MC pro-tumoral role is associated with reduction of NK cell number and activation.…”

Section: Pattern Of MC Membrane-bound Molecules Regulating Immunologimentioning

confidence: 99%

Mast Cell: An Emerging Partner in Immune Interaction

Gri¹,

Frossi²,

D’Incà³

et al. 2012

Front. Immun.

121

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Mast cells (MCs) are currently recognized as effector cells in many settings of the immune response, including host defense, immune regulation, allergy, chronic inflammation, and autoimmune diseases. MC pleiotropic functions reflect their ability to secrete a wide spectrum of preformed or newly synthesized biologically active products with pro-inflammatory, anti-inflammatory and/or immunosuppressive properties, in response to multiple signals. Moreover, the modulation of MC effector phenotypes relies on the interaction of a wide variety of membrane molecules involved in cell–cell or cell-extracellular-matrix interaction. The delivery of co-stimulatory signals allows MC to specifically communicate with immune cells belonging to both innate and acquired immunity, as well as with non-immune tissue-specific cell types. This article reviews and discusses the evidence that MC membrane-expressed molecules play a central role in regulating MC priming and activation and in the modulation of innate and adaptive immune response not only against host injury, but also in peripheral tolerance and tumor-surveillance or -escape. The complex expression of MC surface molecules may be regarded as a measure of connectivity, with altered patterns of cell–cell interaction representing functionally distinct MC states. We will focalize our attention on roles and functions of recently discovered molecules involved in the cross-talk of MCs with other immune partners.

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“…It was reported that, in the presence of agonists for TLR3, TLR4 and TLR9, mast cells in coculture experiments stimulated NK cells to produce IFN-γ in a contact-dependent and TNF-α-independent manner (169).…”

Section: Crosstalk Between Human Nk Cells and Macrophages Infected Wimentioning

confidence: 99%

Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?

Souza-Fonseca-Guimarães

Adib‐Conquy

Cavaillon

2011

Mol Med

133

125

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Natural killer (NK) cells were first described as immune leukocytes that could kill tumor cells and soon after were reported to kill virus-infected cells. In the mid-1980s, 10 years after their discovery, NK cells were also demonstrated to contribute to the fight against bacterial infection, particularly because of crosstalk with other leukocytes. A wide variety of immune cells are now recognized to interact with NK cells through the production of cytokines such as interleukin (IL)-2, IL-12, IL-15 and IL-18, which boost NK cell activities. The recent demonstration that NK cells express pattern recognition receptors, namely Toll-like and nucleotide oligomerization domain (NOD)-like receptors, led to the understanding that these cells are not only under the control of accessory cells, but can be directly involved in the antibacterial response thanks to their capacity to recognize pathogen-associated molecular patterns. Interferon (IFN)-γ is the predominant cytokine produced by activated NK cells. IFN-γ is a key contributor to antibacterial immune defense. However, in synergy with other inflammatory cytokines, IFN-γ can also lead to deleterious effects similar to those observed during sepsis. Accordingly, as the main source of IFN-γ in the early phase of infection, NK cells display both beneficial and deleterious effects, depending on the circumstances.

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Lipopolysaccharide-Mediated Mast Cell Activation Induces IFN-γ Secretion by NK Cells

Abstract: Material

Cited by 35 publications

References 59 publications

Innate Immunity and Its Regulation by Mast Cells

Innate Immunity and Its Regulation by Mast Cells

Mast Cell: An Emerging Partner in Immune Interaction

Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?

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