Lipopolysaccharide facilitates partner preference behaviors in female prairie voles

Sd, Bilbo; Sl, Klein; DeVries, AC; Nelson, Randy J.

doi:10.1016/s0031-9384(99)00154-7

Cited by 29 publications

(14 citation statements)

References 46 publications

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“…This corroborates the absence of a prolonged or repeated elevation of corticosterone levels, which are usually associated with behaviors associated with illness (Zuk and McKean 1996;Bilbo, et al 1999) and thus to a diminution in sexual motivation (Welsh et al 1999). Nevertheless, the fact that the basal plasma corticosterone concentration was always higher in infected males and correlated positively to parasitemia at 5 w.p.i.…”

Section: Discussionsupporting

confidence: 57%

Reduction in testosterone concentration and its effect on the reproductive output of chronic malaria-infected male mice

2004

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An experimental host-parasite association involving BALB/c male mice infected with Plasmodium chabaudi chabaudi was used in order to investigate the influence of the parasite on the sexual physiology and behavior of infected hosts. Infected males displayed complete courtship behavior leading to ejaculation and sired litters on several occasions. A weekly assay of testosterone and corticosterone plasma concentrations revealed a twofold decrease in the testosterone level at 4 and 5 weeks post-injection, during recrudescence. This imbalance was accompanied by a decrease in the overall duration of the social investigation contacts occurring during courtship and by a reduction in the fertilization rate of the infected animals. These physiological perturbations can be regarded as an adaptive response of the host to the recrudescing parasites, which illustrates the rodents' capacity for regulating the testosterone profiles needed to balance the competing demands of immunity and reproduction.

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Section: Discussionsupporting

confidence: 57%

Reduction in testosterone concentration and its effect on the reproductive output of chronic malaria-infected male mice

2004

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“…Similarly, juvenile rhesus monkeys injected with low-dose LPS spent more time in close proximity with and clinging to a familiar cage-mate than did vehicle-injected controls (Willette et al, 2007). Finally, among prairie voles, females injected with LPS (compared with those injected with saline) actually established preferences for a male partner more rapidly (Bilbo et al, 1999). Thus, although inflammation can decrease social approach towards unfamiliar others (Bluthé et al, 1992;Bluthé et al, 1994), it can simultaneously increase social approach behavior towards familiar others, potentially in order to obtain much needed care from them (eg, protection, comfort, and nourishment).…”

Section: Effects Of Inflammation On Social Behavior In Animalsmentioning

confidence: 92%

In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior

Eisenberger

Moieni

Inagaki

et al. 2016

Neuropsychopharmacol

274

200

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Although it has commonly been assumed that the immune system and the processes that govern social behavior are separate, non-communicating entities, research over the past several decades suggests otherwise. Considerable evidence now shows that inflammatory processes and social behavior are actually powerful regulators of one another. This review first summarizes evidence that inflammatory processes regulate social behavior, leading to characteristic changes that may help an individual navigate the social environment during times of sickness. Specifically, this review shows that inflammation: (1) increases threatrelated neural sensitivity to negative social experiences (eg, rejection, negative social feedback), presumably to enhance sensitivity to threats to well-being or safety in order to avoid them and (2) enhances reward-related neural sensitivity to positive social experiences (eg, viewing close others and receiving positive social feedback), presumably to increase approach-related motivation towards others who might provide support and care during sickness. Next, this review summarizes evidence showing that social behavior also regulates aspects of inflammatory activity, preparing the body for situations in which wounding and infection may be more likely (social isolation). Here, we review research showing: (1) that exposure to social stressors increases proinflammatory activity, (2) that individuals who are more socially isolated (ie, lonely) show increased proinflammatory activity, and (3) that individuals who are more socially isolated show increased proinflammatory activity in response to an inflammatory challenge or social stressor. The implications of the co-regulation of inflammation and social behavior are discussed.

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“…Female prairie voles exposed to LPS (versus saline) were faster to establish preferences for a male partner, suggesting that in some cases heightened inflammation may facilitate pair-bonding. 35 These findings suggest that inflammation can lead to increases in social behavior, depending on the context, which may serve an adaptive purpose. 17 Identifying and affiliating with others may provide sick individuals with resources to facilitate recovery from illness.…”

Section: Effects Of Inflammation On Positive Social Experiencementioning

confidence: 98%

Effects of inflammation on social processes and implications for health

Moieni

Eisenberger

2018

Annals of the New York Academy of Sciences

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Although at first glance inflammation and social behavior may appear unrelated, research points to an important role for inflammation in shaping social processes. This review summarizes findings in this field, specifically highlighting work that provides support for the idea that inflammation can lead to (1) increases in sensitivity to negative, threatening social experiences and (2) increases in sensitivity to positive, socially rewarding experiences. These diverging sensitivities in response to inflammation may depend on context and be adaptive for recuperation and recovery from illness. This review also discusses the implications of these findings for health and future research, including implications for depression, loneliness, and inflammatory disorders.

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Lipopolysaccharide facilitates partner preference behaviors in female prairie voles

Cited by 29 publications

References 46 publications

Reduction in testosterone concentration and its effect on the reproductive output of chronic malaria-infected male mice

Reduction in testosterone concentration and its effect on the reproductive output of chronic malaria-infected male mice

In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior

Effects of inflammation on social processes and implications for health

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