Lipopolysaccharide-Binding Protein Is an Early Biomarker of Cardiac Function After Radiation Therapy for Breast Cancer

Chałubińska-Fendler, Justyna; Graczyk, Łukasz; Piotrowski, Grzegorz; Wyka, Krystyna; Nowicka, Zuzanna; Tomasik, Bartłomiej; Fijuth, Jacek; Kozono, David; Fendler, Wojciech

doi:10.1016/j.ijrobp.2019.04.002

Cited by 18 publications

(16 citation statements)

References 39 publications

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“…Several proteins were upregulated with radiation exposure including lipopolysaccharide (LPS)-binding protein, which showed an increased serum abundance at SD 1 for all doses tested in the study, while the levels of relative abundance remained much higher at SD 6 than pre-irradiation serum abundance (Figure 3, Panel A). LPS binding protein has been previously described as a potential early biomarker for cardiac toxicity after radiation therapy (32) and as a biodosimetric marker of radiotherapy in cancer treatments (33)(34)(35). On the other hand, inter-alpha globulin showed a significant decrease after irradiation for all radiation doses with serum abundance that remained significantly dysregulated even after 6 days after radiation exposure (Figure 3, Panel B,).…”

Section: Proteomic Responsementioning

confidence: 87%

Identification of Novel Biomarkers for Acute Radiation Injury Using Multiomics Approach and Nonhuman Primate Model

Cheema¹,

Li²,

Moulton³

et al. 2022

International Journal of Radiation Oncology*Biology*Physics

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Section: Proteomic Responsementioning

confidence: 87%

Identification of Novel Biomarkers for Acute Radiation Injury Using Multiomics Approach and Nonhuman Primate Model

Cheema¹,

Li²,

Moulton³

et al. 2022

International Journal of Radiation Oncology*Biology*Physics

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“…Several proteins were upregulated with radiation exposure including lipopolysaccharide (LPS)-binding protein, which showed an increased serum abundance at SD 1 for all doses tested in the study, while the levels of relative abundance remained much higher at SD 6 than pre-irradiation serum abundance (Figure 3, Panel A). LPS binding protein has been previously described as a potential early biomarker for cardiac toxicity after radiation therapy (17) and as a biodosimetric marker of radiotherapy in cancer treatments (18)(19)(20). On the other hand, inter-alpha globulin showed a significant decrease after irradiation for all doses with serum abundance that remained significantly dysregulated even after SD 6 from radiation exposure (Figure 3, Panel B,).…”

Section: Proteomic Responsementioning

confidence: 87%

Identification of multi-omics molecular signature of acute radiation injury using nonhuman primate model

Cheema

Li²,

Moulton³

et al. 2021

Preprint

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The availability of validated biomarkers to assess radiation exposure and to assist in developing medical countermeasures remains an unmet need. We used a cobalt 60 gamma irradiated nonhuman primate model to delineate a multi-omics based serum probability index of radiation exposure. Both male and female NHPs were irradiated with different doses ranging from 6.0 to 8.5 Gray, with 0.5 Gray increments between doses. We leveraged high resolution mass spectrometry for analysis of metabolites, lipids, and proteins at 1, 2, and 6 days post irradiation in NHP serum. A logistic regression model was implemented to develop a 4 analyte panel to stratify irradiated NHPs from unirradiated with high accuracy that was agnostic for all doses of gamma rays tested in the study, up to six days after exposure. This panel was comprised of Serpin Family A9, acetylcarnitine, PC (16:0/22:6), and suberylglycine, which showed 2 to 4 fold elevation in serum abundance upon irradiation in NHPs, and can potentially be translated for human use following larger validation studies. Taken together, this study, for the first time, demonstrates the utility of a combinatorial molecular characterization approach using an nonhuman primate model for developing minimally invasive assays from small volumes of blood that can be effectively used for radiation exposure assessments.

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“…LBP, as a pattern recognition protein, can activate the cell to produce cytokines when faced with various microbial ligands [17]. Serum LBP was also proved to be a useful prognostic parameter for breast cancer patients after radiation therapy [18]. TFR2, which play a crucial role in the regulation of iron homeostasis, was found high expression in human colon cancer cell [19,20].…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a five-immune gene prognostic risk model in colon cancer

2020

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Background: Colon cancer is a common and highly malignant cancer. Its morbidity is rapidly increasing, and its prognosis is poor. Currently, immunotherapy is a rapidly developing therapeutic modality of colon cancer. This study aimed to construct a prognostic risk model based on immune genes for the early diagnosis and accurate prognostic prediction of colon cancer. Methods: Transcriptomic data and clinical data were downloaded from The Cancer Genome Atlas database. Immune genes were obtained from the ImmPort database. Differentially expressed (DE) immune genes between 473 colon cancer and 41 adjacent normal tissues were identified. The entire cohort was randomly divided into the training and testing cohort. The training cohort was used to construct the prognostic model. The testing and entire cohorts were used to validate the model. The clinical utility of the model and its correlation with immune cell infiltration were analyzed. Results: A total of 333 DE immune genes (176 up-regulated and 157 down-regulated) were detected. We developed and validated a five-immune gene model of colon cancer, including LBP, TFR2, UCN, UTS2, and MC1R. This model was approved to be an independent prognostic variable, which was more accurate than age and the pathological stage for predicting overall survival at five years. Besides, as the risk score increased, the content of CD8+ T cells in colon cancer was decreased. Conclusions: We developed and validated a five-immune gene model of colon cancer, including LBP, TFR2, UCN, UTS2, and MC1R. This model could be used as an instrumental variable in the prognosis prediction of colon cancer.

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Lipopolysaccharide-Binding Protein Is an Early Biomarker of Cardiac Function After Radiation Therapy for Breast Cancer

Cited by 18 publications

References 39 publications

Identification of Novel Biomarkers for Acute Radiation Injury Using Multiomics Approach and Nonhuman Primate Model

Identification of Novel Biomarkers for Acute Radiation Injury Using Multiomics Approach and Nonhuman Primate Model

Identification of multi-omics molecular signature of acute radiation injury using nonhuman primate model

Development and validation of a five-immune gene prognostic risk model in colon cancer

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