Development and validation of a five-immune gene prognostic risk model in colon cancer

Chen, Haitao; Luo, Jun; Guo, Jingyi

doi:10.1186/s12885-020-06799-0

Cited by 56 publications

(41 citation statements)

References 32 publications

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“…Colon cancer and primary liver cancer are common types of cancers in the digestive system (Grandhi et al, 2016;Chen et al, 2020). The expression of E-cadherin and vimentin is considered of high reference value in the prognosis of colon cancer.…”

Section: Effects On Digestive Diseasesmentioning

confidence: 99%

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun

et al. 2020

Front. Pharmacol.

175

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Centella asiatica (also known as Centella asiatica (L.) Urb. or Gotu kola) is a traditional Chinese medicine with extensive medicinal value, which is commonly used in Southeast Asian countries. This study aimed to summarize the effects of C. asiatica and its main components on neurological diseases, endocrine diseases, skin diseases, cardiovascular diseases, gastrointestinal diseases, immune diseases, and gynecological diseases, as well as potential molecular mechanisms, to study the pathological mechanism of these diseases based on the changes at the molecular level. The results showed that C. asiatica and its triterpenoids had extensive beneficial effects on neurological and skin diseases, which were confirmed through clinical studies. They exhibited anti-inflammatory, antioxidative stress, anti-apoptotic effects, and improvement in mitochondrial function. However, further clinical studies are urgently required due to the low level of evidence and lack of patients.

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Section: Effects On Digestive Diseasesmentioning

confidence: 99%

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun

et al. 2020

Front. Pharmacol.

175

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“…Previous studies have found that colon CSCs inhibit immune cells activity in the tumor microenvironment and led to the poor outcome of immunotherapy [37][38][39]. we used the ESTIMATE algorithm to infer immune score and explored the correlation between immune score and mRNAsi score and COAD stemness-related genes [40]. The immune scores were found to be negatively correlated with the mRNAsi scores and COAD stemness-related genes.…”

Section: Discussionmentioning

confidence: 98%

High Expression of TTK As Colon Stem Cell Marker Correlated With M1 Macrophages Infiltration

Chen

Wu³

et al. 2021

Preprint

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Background: Tumor stemness-related genes promote tumor progression and resistance to immunotherapy, but the relation between tumor-infiltrating immune cells and colon adenocarcinoma (COAD) stemness-related genes remains unclear. Methods: The mRNAsi scores, a stemness index derived from transcriptomic data of the TCGA COAD cohort were used for integrated bioinformatics analysis. The Weighted Gene Co-expression Network Analysis (WGCNA) was applied to classify the modules correlated with mRNAsi scores. The Gene Expression Omnibus (GEO) cohorts GSE76402 was used to verify the DEGs between colon cancer and normal tissues. Real-time PCR and Flow-cytometry were used to validate the expression of genes and cancer stem cells marker in the spheres of colon cancer cells. The Single-sample Gene Set Enrichment Analysis (ssGSEA) and CIBERSORT algorithm were used to explore the correlation between significant genes and the immune cells in tumor microenvironment. Result: The mRNAsi score was associated with tumor development and progression. TTK were identified as COAD stemness-related genes based on WGCNA analysis. TTK were negatively correlated with immunity. Interestingly, M1 Macrophages had a higher infiltration in COAD with high TTK expression. Higher infiltration of M1 Macrophages would result in the worse survival rate of COAD patients. Conclusion: TTK may have the potential as a prognostic biomarker and adjuvant target to promote immunotherapy sensitivity and improve outcomes of COAD patients.

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“…Studies have found that urotensin-II could contribute to breast carcinogenesis and Thr21Met polymorphism can be an important risk factor in developing breast tumors [38]. UTS2 might be used as potential targets to improve diagnosis and immunotherapy biomarkers for renal cell carcinoma and colon cancer [39][40].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Prognosis Related Genes in HER2+ Breast Cancer Based on Weighted Gene Co-expression Network Analysis

Weng

Jia

et al. 2021

Preprint

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Background: Breast cancer is one of the malignant tumors that threaten women's health, with HER2+ breast cancer being more aggressive. In this study, bioinformatics methods were used to find potential key genes in HER2 + for diagnosis and treatment.Methods: Datasets of HER2+ breast cancer and normal tissue samples retrieved from TCGA databases were subjected to DEGs analysis using R software. Then WGCNA is constructed for DEGs. The key gene co-expression modules were then subjected to GO and KEGG pathway enrichment analyses, as well as construction of PPI networks using the STRING database for identifying key genes. Finally, key genes were further validated by survival analysis, protein expression, and COX regression models.Results: We identified 2063 DEGs and 4 gene co-expression modules. Functional enrichment analysis showed that these key co-expression modules were mainly associated with extracellular matrix organization, extracellular matrix structural constituent and neuroactive ligand−receptor interaction. PPI network visualization identified 100 key genes, 3 of which were not present in the other subtypes of breast cancer. UTS2 DRD4 and GLP1R are key genes specific to the HER2+ subtype. Survival analysis showed that UTS2 are prognosis-related key genes in HER2+ breast cancer. Finally, UTS2 combined with clinical data to construct Cox regression model.Conclusions: Combined with the two screening methods, 3 key genes closely related to HER2 + breast cancer were identified. UTS2 is a new potential key gene and may become a new therapeutic target for HER2 + breast cancer.

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Development and validation of a five-immune gene prognostic risk model in colon cancer

Cited by 56 publications

References 32 publications

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

High Expression of TTK As Colon Stem Cell Marker Correlated With M1 Macrophages Infiltration

Analysis of the Prognosis Related Genes in HER2+ Breast Cancer Based on Weighted Gene Co-expression Network Analysis

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