Lipophilisation de composés phénoliques par voie enzymatique et propriétés antioxydantes des molécules lipophilisées

Influence of AO chain length, droplet size and oil to water ratio on the distribution and on the activity of gallates in fish oil-in-water emulsified systems: Emulsion and nanoemulsion comparison

“…Nevertheless, we are still unable to predict how the intrinsic chemical structure of antioxidants affects their behavior in different food systems. In recent years, the lipophilization of hydrophilic molecules to synthesize antioxidants with a broad range of hydrophobicity has attracted interest Lopez Giraldo et al, 2007). This is due to the possibility to fine-tune the hydrophobicity of a polyphenol by the grafting alkyl chains of different length and should help us to understand how antioxidant properties are affected by the hydrophobicity.…”

Evaluation of deep eutectic solvent–water binary mixtures for lipase-catalyzed lipophilization of phenolic acids

“…The second strategy offers several advantages: milder reaction conditions, reduced by-product formation and purification steps, and a more environmentally friendly process. [14][15][16] However, one of the difficulties involved in this biocatalyzed reaction lies in optimizing the synthesis (yields and kinetics) with two substrates of different polarities. Therefore, it is of paramount importance to select media in which both polar (e.g.…”

Enzymatic synthesis of designer lipids

“…While lipases from many sources have been employed to date, the immobilized lipase Novozym 435 from C. antarctica is extremely robust and among the most effective and commonly used. With regards to the reaction system, synthesis of bioactive compounds has been carried out in organic solvent [23], solvent-free systems [24] as well as in novel media, such as room temperature ionic liquids (RTILs) [28]. In all of these systems, the major challenge lies in the bringing together of substrates (i.e.…”

“…Changes in product partitioning as well as improved emulsification properties also expand the applications of these products. To date, designer bioactive compounds have already been successfully synthesized [23][24][25][26][27] using a host of bioactive structures and acyl groups of varying chain lengths and unsaturation through enzymatic modification as shown in figure 4. Lipases were used to catalyze both the esterification and transesterification reactions of bioactive compounds with acyl groups.…”

“…Proper adjustment of the above-mentioned parameters can help to push the reaction equilibrium towards the production of these bioactive compounds and result in a more cost effective reaction set-up. Figure 4, details the reactions of several bioactive compounds, including dihydrocaffeic acid [23], ferulic acid [24], rutin [25] and a-tocopherol [26,27] to yield some designer bioactive compounds. It may be noted from this figure that things like the placement of substituent on the phenolic ring and the presence of a double bond on the side chain conjugated with the ring structure affect bioconversion yield.…”