Liponeurofibroma on the Hard Palate: Case Report of a Rare Microscopic Variant

Dotta, Jéssica Helena; Barbeiro, Camila De Oliveira; Silveira, Heitor Albergoni; Ferrisse, Túlio Morandin; León, Jorge Esquiche; Massucato, Elaine Sgavioli; Bufalino, Andréia

doi:10.1016/j.oooo.2019.06.514

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

2020

DOI: 10.1016/j.oooo.2019.06.514

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Liponeurofibroma on the Hard Palate: Case Report of a Rare Microscopic Variant

Jéssica Helena Dotta¹,

Camila De Oliveira Barbeiro²,

Heitor Albergoni Silveira³

et al.

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“…The microscopical differential diagnosis of FH/IFH presenting lipometaplasia includes lipoma, notably low-fat/fat-free spindle cell lipoma (SCL), fibrolipoma, and sclerotic (fibroma-like) lipoma, mesenchymal non-lipogenic neoplasms, such as liponeurofibroma and lipomatous perineurioma, and rare disorders such as benign symmetrical lipomatosis (BSL) [7][8][9][10][11][12][13][14] (Figure 2B,C). Most cases can be differentiated from FH/IFH by detailed morphological analysis of the non-lipogenic component.…”

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Lipometaplasia in fibrous hyperplasia and inflammatory fibrous hyperplasia of the oral cavity

et al. 2023

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O N Lipometaplasia in fibrous hyperplasia and inflammatory fibrous hyperplasia of the oral cavity Fibrous hyperplasia (FH) is a reactive hyperplastic lesion of the connective tissue, being considered the most common intraoral lesion.When an inflammatory component is detected, usually on microscopic analysis, it is diagnosed as inflammatory FH (IFH). FH/IFH affects predominantly adult women. Clinically, it presents as a yellowish-white or normal-appearing mucosal-colored, sessile or pedunculated, irregular or smooth-surfaced nodular lesion, preferentially located on alveolar ridge, buccal mucosa, gingiva, tongue, and lips. Moreover, hyperkeratotic, erythematous, or ulcerated surface, owing to repeated trauma, is often observed in IFH cases. The pathogenesis is often associated with chronic (low-intensity) irritating factors such as illfitting prostheses, fractured teeth, retained root remnants, parafunctional habits, poor oral hygiene, and occlusal trauma. [1][2][3] Microscopically, oncocytic, squamous, chondromatous, and osseous metaplasia in IFH cases has been described. 1-3 However, we have detected lipometaplasia (adipose metaplasia) in typical FH/IFH cases, which led us to carry out a comprehensive study in order to determine their clinicopathological features.This study was approved by the Ethics Committee (92272218.5.0000.5419). We retrospectively assessed 792 cases diagnosed as intraoral FH/IFH, between 2010 and 2021. Patient data such as gender, age, location of the lesion, and associated local irritating factor were obtained from dental records. Archived slides stained with hematoxylin and eosin (H&E), obtained from Oral Histopathology

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Lipometaplasia in fibrous hyperplasia and inflammatory fibrous hyperplasia of the oral cavity

et al. 2023

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Liponeurofibroma on the Hard Palate: Case Report of a Rare Microscopic Variant

Cited by 1 publication

References 0 publications

Lipometaplasia in fibrous hyperplasia and inflammatory fibrous hyperplasia of the oral cavity

Lipometaplasia in fibrous hyperplasia and inflammatory fibrous hyperplasia of the oral cavity

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