Lipometaplasia in fibrous hyperplasia and inflammatory fibrous hyperplasia of the oral cavity

Abstract

O N Lipometaplasia in fibrous hyperplasia and inflammatory fibrous hyperplasia of the oral cavity Fibrous hyperplasia (FH) is a reactive hyperplastic lesion of the connective tissue, being considered the most common intraoral lesion.When an inflammatory component is detected, usually on microscopic analysis, it is diagnosed as inflammatory FH (IFH). FH/IFH affects predominantly adult women. Clinically, it presents as a yellowish-white or normal-appearing mucosal-colored, sessile or pedunculated, irregular or smooth-surfaced nodular lesion, preferentially located on alveolar ridge, buccal mucosa, gingiva, tongue, and lips. Moreover, hyperkeratotic, erythematous, or ulcerated surface, owing to repeated trauma, is often observed in IFH cases. The pathogenesis is often associated with chronic (low-intensity) irritating factors such as illfitting prostheses, fractured teeth, retained root remnants, parafunctional habits, poor oral hygiene, and occlusal trauma. [1][2][3] Microscopically, oncocytic, squamous, chondromatous, and osseous metaplasia in IFH cases has been described. 1-3 However, we have detected lipometaplasia (adipose metaplasia) in typical FH/IFH cases, which led us to carry out a comprehensive study in order to determine their clinicopathological features.This study was approved by the Ethics Committee (92272218.5.0000.5419). We retrospectively assessed 792 cases diagnosed as intraoral FH/IFH, between 2010 and 2021. Patient data such as gender, age, location of the lesion, and associated local irritating factor were obtained from dental records. Archived slides stained with hematoxylin and eosin (H&E), obtained from Oral Histopathology

Identification, Cause and Surgical Management of Traumatic Fibroma in the Jugal Mucosa: A Case Report

“…The degree of malignancy of these hyperplastic lesions is low, to the point that the literature has little evidence when addressing changes in the clinical/histological characteristics of hyperplastic tissue due to recurrent chronic irritants. However, these lesions may clinically present similarities to other oral lesions depending on the location, necessitating a differential diagnosis, which includes: hemangioma, sarcoma, and carcinoma, as well as lesions with similar patterns such as mucocele, ranula, and pyogenic granuloma [8,13].…”

“…Because they are common injuries found in the oral region, they have patterns similar to other commonly found injuries [7]. Pyogenic granuloma, mucocele, ranula and papilloma are some pathologies similar in appearance to traumatic fibroma [8]. Histologically, it is identified in sections, highlighting the presence of stratified squamous epithelial tissue, consisting of abundant collagen fibers, in addition to variable blood vessels and inflammatory infiltrates [9].…”