Lipomatous pseudohypertrophy of the pancreas in a patient with cirrhosis due to chronic hepatitis B

Sasaki, Motoko; Nakanuma, Y; Ando, Hltoshi

doi:10.1111/j.1440-1827.1998.tb03951.x

Cited by 26 publications

(23 citation statements)

References 6 publications

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“…Chronic liver disease: Yoshimura et al[131] and Sasaki et al[132] suggested that lipomatous pseudohypertrophy of the pancreas might be caused by chronic advanced hepatic lesions, which lead to ductal obstruction. Thus now, only case reports of patients with chronic hepatitis B and liver cirrhosis support this hypothesis[49,132,133].…”

Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

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Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease

Catanzaro¹,

Cuffari²,

Italia³

et al. 2016

WJG

157

132

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After the first description of fatty pancreas in 1933, the effects of pancreatic steatosis have been poorly investigated, compared with that of the liver. However, the interest of research is increasing. Fat accumulation, associated with obesity and the metabolic syndrome (MetS), has been defined as “fatty infiltration” or “nonalcoholic fatty pancreas disease” (NAFPD). The term “fatty replacement” describes a distinct phenomenon characterized by death of acinar cells and replacement by adipose tissue. Risk factors for developing NAFPD include obesity, increasing age, male sex, hypertension, dyslipidemia, alcohol and hyperferritinemia. Increasing evidence support the role of pancreatic fat in the development of type 2 diabetes mellitus, MetS, atherosclerosis, severe acute pancreatitis and even pancreatic cancer. Evidence exists that fatty pancreas could be used as the initial indicator of “ectopic fat deposition”, which is a key element of nonalcoholic fatty liver disease and/or MetS. Moreover, in patients with fatty pancreas, pancreaticoduodenectomy is associated with an increased risk of intraoperative blood loss and post-operative pancreatic fistula.

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Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

“…Thus now, only case reports of patients with chronic hepatitis B and liver cirrhosis support this hypothesis[49,132,133]. …”

Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease

Catanzaro¹,

Cuffari²,

Italia³

et al. 2016

WJG

157

132

View full text Add to dashboard Cite

show abstract

“…Other diseases associated include congenital syndromes such as cystic fibrosis [18-21], Shwachman-Diamond syndrome [22, 23], Johanson-Blizzard syndrome [24] and heterozygous carboxyl-ester-lipase mutations [25]. Pancreatic steatosis has also been associated with hemochromatosis [11], viral infections such as hepatitis B [26] and malnutrition states such as kwashiorkor [27]. …”

Section: Etiologymentioning

confidence: 99%

Non-Alcoholic Fatty Pancreatic Disease: A Review of Literature

et al. 2016

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There is an epidemic of obesity worldwide. The prevalence of obesity has doubled over the last three decades. Obesity, especially abdominal obesity is associated with insulin resistance that can lead to pancreatic steatosis and non-alcoholic fatty pancreatic disease (NAFPD). NAFPD describes a phenotype entity ranging from deposition of fat in the pancreas to pancreatic inflammation, and resultant fibrosis, which is similar to that of non-alcoholic fatty liver disease (NAFLD). NAFPD may represent a meaningful manifestation of metabolic syndrome. Pancreatic steatosis can be diagnosed on ultrasound, computed tomography (CT) scan or magnetic resonance imaging (MRI). In addition to a correlation between pancreatic steatosis and metabolic syndrome, pancreatic steatosis may lead to a worse outcome in pancreatitis and may be an etiological factor in pancreatic cancer, but we need further research to examine the associations, pathophysiology, and the impact of pancreatic steatosis and NAFPD on the human health.

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“…A literature search of Japana Centra Revuo Medicina and PubMed revealed only 27 other cases worldwide, including those in which the condition was diagnosed with imaging alone [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16]. Unlike steatosis resulting from obstruction of the pancreatic duct by pancreatolithiasis or a tumor, the causal factors of this disease are unknown.…”

Section: Discussionmentioning

confidence: 99%

Lipomatous Pseudohypertrophy of the Pancreas Taking the Form of Huge Massive Lesion of the Pancreatic Head

Shimada¹,

Shibahara²,

Kitamura³

et al. 2010

Case Rep Gastroenterol

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A 70-year-old woman presented with hypogastric pain. Computed tomography and magnetic resonance imaging revealed a retroperitoneal tumor 18.0 cm in diameter with fatty tissue density, ventrally compressing the pancreatic head. We suspected a well-differentiated liposarcoma compressing the pancreas. At laparotomy, the tumor mass was the size of an infant’s head; its center was located in the area corresponding to the pancreatic uncus. It was continuous with the pancreatic parenchyma through a poorly demarcated border, and we resected as much of the tumor mass as possible while conserving the pancreatic capsule. Histopathological examination indicated lipomatous pseudohypertrophy of the pancreas with proliferation of mature fatty tissue as the main constituent. At the periphery, islands of acinar tissue were retained among the fatty infiltration, which also contained branches of the pancreatic duct and islets of Langerhans. Previous reports have stated that this disorder only causes fatty replacements throughout the pancreas or in the pancreatic body and tail; however, in this patient, imaging and macroscopic examination revealed no fatty replacements in the pancreatic body and tail. We report this case, which we consider extremely rare, along with a brief review of the literature.

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Lipomatous pseudohypertrophy of the pancreas in a patient with cirrhosis due to chronic hepatitis B

Cited by 26 publications

References 6 publications

Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease

Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease

Non-Alcoholic Fatty Pancreatic Disease: A Review of Literature

Lipomatous Pseudohypertrophy of the Pancreas Taking the Form of Huge Massive Lesion of the Pancreatic Head

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