Lipomas of the oral cavity: clinical and histopathologic study of 41 cases in a Brazilian population

Abstract

This study evaluated the clinical and histopathologic aspects of 41 cases of oral lipomas diagnosed in a Brazilian population. All records from patients diagnosed with oral lipoma between 1970 and 2008 were reviewed. Histological sections were evaluated by light microscopy. There was a predominance of females (2.4:1), with a peak incidence between the sixth and seventh decade. The buccal mucosa was the most aVected site (53.7%), followed by the buccal sulcus (14.6%) and tongue (9.8%). Tumor size ranged from 0.5 to 10 cm and the mean reported duration was 48 months. Histologically, the following variants were identiWed: lipoma (41.5%), Wbrolipoma (34.1%), spindle cell lipoma (9.8%), sialolipoma (9.8%), osteolipoma (2.4%), and chondrolipoma (2.4%). Most tumors were well delimited, irrespective of the variant. Lipomas are rare tumors of the oral cavity. The characterization of new variants, such as sialolipomas, and the identiWcation of histological subtypes in already known variants, such as low-fat and fat-free spindle cell lipomas, highlight the importance for careful microscopic evaluation of these tumors, which might be combined with immunohistochemistry in some cases.

Lipomas of the Oral Cavity: Clinicopathological and Immunohistochemical Study of 24 Cases and Review of the Literature

“…The mean duration between the first awareness of symptoms and treatment was reported to be ranged 31.2-75.8 months [4,7,8,13,15], and our study showed 12 months. The mean tumor size was previously reported to be ranged from 0.8 to 2.6 cm, and our study showed 2.0 cm.…”

“…Most cases of lipoma occur at 60 years of age or older, and are rare in children [4][5][6][7][8][9][10][11][12][13][14][15]. In our study, the mean age of the patients was 59 years, with only one case being less than 40 years old.…”

“…The most common site of oral lipomas has been reported as the buccal mucosa, comprising 38.6 % of all cases, followed by the tongue, lip, floor of the mouth and buccal vestibule, palate and retromolar area, gingiva, and others [4][5][6][7][8][9][10][11][12][13][14][15]. Our study also revealed that the most common site was the buccal mucosa, followed by the tongue, lip, and oral floor, and obtained similar results.…”

“…Lipoma of the oral cavity is treated by conservative local excision and local recurrence is extremely rare [4,7,8]. No significant differences have been reported in prognoses between the major histopathological variants of lipomas [8].…”

“…We here analyzed the clinicopathological features and proliferative activities of 24 cases of oral lipomas in our department, and compared the results with 603 cases reported in the literature in English [4][5][6][7][8][9][10][11][12][13][14][15].…”