Lipolytic Activity of Corynebacterium Acnes**From the Department of Medicine, Division of Dermatology, Harbor General Hospital, Torrance, California 90509, and the Department of Medicine.Division of Dermatology, UCLA School of Medicine, Los Angeles, California 90024.

Reisner, Ronald M.; Silver, Donald Z.; Puhvel, Madli; Sternberg, Thomas H.

doi:10.1038/jid.1968.113

Cited by 54 publications

(1 citation statement)

References 6 publications

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“…As lipase could not be produced by dead keratinized squamae or by sebaceous glands usually absent in comedo-bearing follicles, they regarded it as highly probable that Propionibacterium acnes in great numbers inside the comedones generated the lipases [60]. P. acnes was in fact demonstrated to play an important role by causing a breakdown of the lipids [61]. In vitro experiments indicated that Staphylococcus albus and P. ovale possess the enzymatic material indispensable to hydrolyze triglycerides [62,63].…”

Section: Seborrhea and Acne: Inseparable Players Of The Pathogenic Prmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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