Acne vulgaris. Studies in pathogenesis: triglyceride hydrolysis by Corynebacterium acnes in vitro

Kellum, Robert E.

doi:10.1001/archderm.101.1.41

Cited by 26 publications

(7 citation statements)

References 12 publications

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“…In light of the significance assigned to gelatin liquefaction in separating the two types, it should be noted that group II strains hydrolyze Kohn's charcoal gelatin pellets as used by Zierdt et al (22); apparently, digestion of Formalin-denatured gelatin is not equivalent to digestion of untreated gelatin. Strains of both groups I and II were found to be generally lipolytic on tributyrin and triolein, in accord with the evidence of others (9,18) that C. acnes produces lipase. There is, however, considerable variation in the lipolytic activity of various strains.…”

Section: Resultssupporting

confidence: 89%

Differentiation of Two Groups of Corynebacterium acnes

Voss¹

1970

J Bacteriol

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One hundred and forty-three strains of Corynebacterium acnes, isolated from human skin and acne lesions, were compared with three strains of Propionibacterium acnes from the American Type Culture Collection. The 146 organisms could be separated into two groups. Members of the larger group (129 strains) hydrolyzed gelatin and usually produced indole, Gel-In(+), but were unable to fernent trehalose, maltose, or sucrose, TMS(-). The deoxyribonucleic acid from selected strains of this group had an average guanosine + cytosine (GC) content of 60.5%. The members of the smaller group (17) were Gel-In(-), TMS(+), and the deoxyribonucleic acid had an average GC content of 63.9%/; Studies with absorbed and unon July 31, 2020 by guest

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Section: Resultssupporting

confidence: 89%

Differentiation of Two Groups of Corynebacterium acnes

Voss¹

1970

J Bacteriol

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“…Propionibacteria can be isolated both from the skin surface and from the pilosebaceous ducts (Puhvel et al, 1975). They produce a variety of extracellular enzymes including lipase (Hassing, 1971 ; Kellum et a/., 1970;Ingham et al, 1981 ;Greenman et al, 1981), hyaluronidase (hyaluronidase lyase) (Puhvel & Reisner, 1972;Ingham et al, 1979;Greenman et al, 1981), protease and DNAase (Marples & McGinley, 1974) and acid phosphatase (Ingham et al, 1980;Greenman et al, 1981). Holland et al (1978) suggested that altered conditions in the pilosebaceous duct, i.e.…”

Section: Introductionmentioning

confidence: 99%

Effects of Oxygen Concentration on Biomass Production, Maximum Specific Growth Rate and Extracellular Enzyme Production by Three Species of Cutaneous Propionibacteria Grown in Continuous Culture

1983

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Propionibacterium acnes, Propionibacterium avidum and Propionibacterium granulosum were grown in continuous culture at 0-100% air saturation using a semi-synthetic medium. Maximum specific growth rate, biomass concentration and extracellular lipase, hyaluronate lyase and phosphatase activities were determined. All three species were capable of growth at 100% air saturation but at reduced growth rates. The presence of oxygen altered the production of extra-cellular enzymes. Propionibacterium avidum was the best adapted for growth in aerobic environments.

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“…THE ORGANISM Propionibacterium acnes has been implicated in the disease acne vulgaris (Voss 1976) and has been shown to produce a lipase (Kellum et a/. 1970;Puhvel & Reisner 1970;Hassing 1971;Weaber et al 1971) a hyaluronidase and a protease (Marples & McGinley 1974).…”

mentioning

confidence: 99%

Growth of Cutaneous Propionibacteria on Synthetic Medium; Growth Yields and Exoenzyme Production

Holland

Greenman

Cunliffe

1979

Journal of Applied Bacteriology

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A synthetic medium containing only low molecular weight components has been developed to grow Propionibacterium acnes (P. acnes), P. avidum and P. granulosum. The medium supported the growth of 30/32 typed strains, and when solidified with agar supported the growth of these bacteria isolated directly from the skin. The mean overall efficiency of isolation on the synthetic medium was 57% that of reinforced clostridial medium (RCM). Batch culture experiments with glucose, fructose, glycerol or arginine in the medium showed that the concentrations as well as the type of carbon energy sources used could effect growth and exocellular enzyme production by these organisms.

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Acne vulgaris. Studies in pathogenesis: triglyceride hydrolysis by Corynebacterium acnes in vitro

Cited by 26 publications

References 12 publications

Differentiation of Two Groups of Corynebacterium acnes

Differentiation of Two Groups of Corynebacterium acnes

Effects of Oxygen Concentration on Biomass Production, Maximum Specific Growth Rate and Extracellular Enzyme Production by Three Species of Cutaneous Propionibacteria Grown in Continuous Culture

Growth of Cutaneous Propionibacteria on Synthetic Medium; Growth Yields and Exoenzyme Production

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