Lipoic acid and bone marrow derived cells therapy induce angiogenesis and cell proliferation after focal brain injury

Paradells, Sara; Zipančić, Ivan; Martínez-Losa, María Magdalena; Esparza, María Ángeles García; Bosch‐Morell, Francisco; Álvarez‐Dolado, Manuel; Soria, José Miguel

doi:10.3109/02699052.2014.973448

Cited by 6 publications

(4 citation statements)

References 98 publications

(114 reference statements)

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“…Although several studies shows the anti-proliferative capacity of LA on tumor cells [28] [29] [30], on the other hand, one recent study have reported the beneficial effect of LA promoting cell survival, angiogenesis and neuroregeneration after brain injury [31]. In our study, LA increased the number of cells after 8 days in culture suggesting the applicability of using LA in cell culture to quicken proliferation ( Figure 6).…”

Section: Discussionsupporting

confidence: 44%

Effect of -Lipoic Acid on Proteasomal Induction: Protection against Oxidative Damage in Human Skin Fibroblasts Cell Line NHDF

Sikdar¹,

Papadopoulou²,

Dubois³

2017

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As human skin is daily exposed to oxidative stress causing various unesthetical abnormalities, the road to effective anti-aging substances is being widely investigated. 20S proteasome is a key pathway in the breakdown of oxidized proteins. But its activity declines dramatically in aging cells. Nrf2 inducers α-lipoic acid (LA) and sulforaphane (SFN) have been described in the dietary industries for their antioxidant effects on various cell lines. However, since little is yet known about LA's capacity to protect skin cells from premature and extrinsic aging; our aim was to demonstrate the beneficial effect of LA on the cellular detoxification systems. On this purpose, we evaluated its effects against injuries induced by H 2 O 2 in NHDF and its likely positive effect on the chymotrypsin-like (CT-like) activity of 20S proteasome, using SFN as a reference. The cellular content in proteins was measured, as well as the production of Reactive Oxygen Species (ROS). Also, the induction of the proteasomal protein expression was investigated. The results show that after 48 h treatment, LA significantly decreased the percentage of ROS positive cells. Also, LA decreased the level of H 2 O 2 -induced carbonylated proteins and increased the proteasomal activity. Furthermore, LA upregulated the expression of the 20S proteasome β-subunit responsible for the CT-like activity (PSMB5).Overall, both molecules enhanced cell proliferation over 8 days. So, our investigation found evidence of the higher capacity of LA to induce 20S proteasome activity with less toxicity in human fibroblasts compared to reference molecule SFN. These results tend to demonstrate that the induction of the proteasomal activity might be a part of the antioxidant potential of LA. To our knowledge, this is the first study to elucidate the capacity of LA to activate

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Section: Discussionsupporting

confidence: 44%

Effect of -Lipoic Acid on Proteasomal Induction: Protection against Oxidative Damage in Human Skin Fibroblasts Cell Line NHDF

Sikdar¹,

Papadopoulou²,

Dubois³

2017

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“…Vascularisation further attracts microglia and induces their colonization into scaffold, which leads to differentiation of BMSCs to become brain tissue, within 16 wks of transplantation. In this approach, healing of tissue directly depends on number of BMSCs in transplantation dose [ 76 ]. Dental caries and periodontal disease are common craniofacial disease, often requiring jaw bone reconstruction after removal of the teeth.…”

Section: Bmscs In Regenerative Medicinementioning

confidence: 99%

Stem Cells Applications in Regenerative Medicine and Disease Therapeutics

Mahla

2016

International Journal of Cell Biology

454

294

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Regenerative medicine, the most recent and emerging branch of medical science, deals with functional restoration of tissues or organs for the patient suffering from severe injuries or chronic disease. The spectacular progress in the field of stem cell research has laid the foundation for cell based therapies of disease which cannot be cured by conventional medicines. The indefinite self-renewal and potential to differentiate into other types of cells represent stem cells as frontiers of regenerative medicine. The transdifferentiating potential of stem cells varies with source and according to that regenerative applications also change. Advancements in gene editing and tissue engineering technology have endorsed the ex vivo remodelling of stem cells grown into 3D organoids and tissue structures for personalized applications. This review outlines the most recent advancement in transplantation and tissue engineering technologies of ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs in regenerative medicine. Additionally, this review also discusses stem cells regenerative application in wildlife conservation.

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“…Combinations of antioxidant medications, including NAC and anti-inflammatory medications, have been shown to have beneficial effects on glial cells with reduced neuroinflammation and improved functional outcomes in preclinical studies [ 21 , 29 , 33 , 43 ]. Free radical scavenging antioxidant agents, such as lipoic acid and DHA in combination with anti-inflammatory medications including curcumin, have been used as an adjunct to neural stem cell grafting, with positive effects on cell graft survival and neuronal differentiation [ 20 , 31 , 39 ]. Combinations of NMDA receptor antagonist anti-excitatory medications, such as memantine and endogenous hormones including estrogen, have been shown to reduce neuronal death in preclinical models [ 34 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review

Lynch

Narayan

2023

JCM

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Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite extensive research efforts, the majority of trialed monotherapies to date have failed to demonstrate significant benefit. It has been suggested that this is due to the complex pathophysiology of TBI, which may possibly be addressed by a combination of therapeutic interventions. In this article, we have reviewed combinations of different pharmacologic treatments, combinations of non-pharmacologic interventions, and combined pharmacologic and non-pharmacologic interventions for TBI. Both preclinical and clinical studies have been included. While promising results have been found in animal models, clinical trials of combination therapies have not yet shown clear benefit. This may possibly be due to their application without consideration of the evolving pathophysiology of TBI. Improvements of this paradigm may come from novel interventions guided by multimodal neuromonitoring and multimodal imaging techniques, as well as the application of multi-targeted non-pharmacologic and endogenous therapies. There also needs to be a greater representation of female subjects in preclinical and clinical studies.

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Lipoic acid and bone marrow derived cells therapy induce angiogenesis and cell proliferation after focal brain injury

Cited by 6 publications

References 98 publications

Effect of -Lipoic Acid on Proteasomal Induction: Protection against Oxidative Damage in Human Skin Fibroblasts Cell Line NHDF

Effect of -Lipoic Acid on Proteasomal Induction: Protection against Oxidative Damage in Human Skin Fibroblasts Cell Line NHDF

Stem Cells Applications in Regenerative Medicine and Disease Therapeutics

Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review

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