Lipofuscin ("Wear and Tear Pigment") in Human Sweat Glands

“…The granules of lipofuscin were found exclusively within cells of the secretory tubules of eccrine sweat glands and were never observed in the lumina of the glands, as noted by Cawley et al This pattern has been noted as a potential pitfall in the diagnosis of vasculitis . However, awareness of the patterns of lipofuscin could make it easier to distinguish from relevant positive immunofluorescence within eccrine glands (Table ).…”

Section: Discussionmentioning

confidence: 79%

Diagnostic value of eccrine glands and hair follicles in direct immunofluorescent analysis of pemphigus vulgaris and bullous pemphigoid

Zhou

Elston

2016

J Cutan Pathol

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The immunofluorescence pattern in adnexal structures may be of value, especially when the epidermis is not well represented in diagnostic sections. We studied a total of 88 cases of pemphigus vulgaris (PV) and bullous pemphigoid (BP) accessioned between 2010 and 2015 (40 cases of PV and 48 cases of BP). Immunofluorescence patterns and sensitivity in adnexal structures were similar to those observed in the epidermis. One case of PV and three cases of BP showed weak or absent fluorescence in the epidermis, while the eccrine glands were strongly positive, suggesting that careful examination of adnexal structures can be of value.

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“…The epithelium of the secretory duct and coil is noted to shrink 8 resulting in an uneven appearance and luminal dilatation, and associated with glandular disarray and/or involution 8 . Lipofuscin, the “wear‐and‐tear pigment,” accumulates within the eccrine secretory cells; granules increase in both number and size with progressive aging 8,39 …”

Section: The Appendagesmentioning

confidence: 99%

Histologic Changes in Skin Associated with Aging

Kurban

Bhawan

1990

The Journal of Dermatologic Surgery and Oncology

182

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This is a review of histologic changes noted in the skin of elderly individuals. Among the epidermal changes associated with skin aging are a flattened dermal-epidermal junction, giving the appearance of atrophy and cellular heterogeneity. The melanocyte density declines slowly, and the Langerhans cells decrease in number with advancing age. Among the dermal changes are attenuation in the number and diameter of elastic fibers in the papillary dermis, an increase in number and thickness of the same fibers in the reticular dermis, and a coarsening of collagen fibers with an increase in density of the collagen network. A decrease in the dermal cell population as well as a functional decline in glandular activity are also noted with intrinsic aging. A decline in hair number, rate of growth, and diameter, along with a slowing of the rate of growth of nails, have been well documented with progressive aging.

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Lipofuscin ("Wear and Tear Pigment") in Human Sweat Glands

Cited by 18 publications

References 12 publications

Potential diagnostic pitfall in direct immunofluorescence evaluation for vasculitis in skin biopsies: fluorescent secretory granules within eccrine glands

Potential diagnostic pitfall in direct immunofluorescence evaluation for vasculitis in skin biopsies: fluorescent secretory granules within eccrine glands

Diagnostic value of eccrine glands and hair follicles in direct immunofluorescent analysis of pemphigus vulgaris and bullous pemphigoid

Histologic Changes in Skin Associated with Aging

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