Lipoblastoma in infants and children

Stringel, Gustavo; Shandling, Barry; Mancer, Kent; Ein, Sigmund H.

doi:10.1016/s0022-3468(82)80012-2

Cited by 113 publications

(88 citation statements)

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“…[1][2][3][4][5][6] Adipose tissue tumors are relatively infrequent in childhood; they represent 6% of soft tissue tumors in the first two decades and 7% in the first year of life. 1,2 In children and adolescents, lipoblastoma represents 30% of adipose tissue tumors.…”

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confidence: 99%

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Leon

Deschler

et al. 2002

Acta Cytologica

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confidence: 99%

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Leon

Deschler

et al. 2002

Acta Cytologica

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“…No permiten hacer un adecuado diagnóstico diferencial entre las diferentes neoplasias de tejido graso. [6][7][8][9] La RMN sigue siendo el método más sensible para el diagnóstico; el aumento de la vascularización en los lipoblastomas, en comparación con los lipomas, muestra una menor intensidad en las imágenes ponderadas T1. 9 La citología por punción y aspiración con agua fina es un método diagnóstico que está descrito La anatomía patológica confirma el origen de la lesión.…”

Section: Discussionunclassified

“…El tiempo de seguimiento es controversial; se sugiere de uno a tres años. 5,7,8 La recidiva aumenta en el caso de lipoblastomatosis. Estos se presentan hasta 84 meses después de la resección, generalmente, dentro de los 2 primeros años de seguimiento, por lo que se recomienda una vigilancia posoperatoria constante de, al menos, 5 años: cada 2 meses durante el primer año, cada 6 durante el segundo y tercer año y luego de forma anual.…”

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Lipoblastoma retroperitoneal gigante. Caso clínico

Rosière

Falcioni

Navacchia

et al. 2018

Arch Argent Pediatr

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Presentación de casos clínicos RESUMENEl lipoblastoma forma parte de los tumores derivados del tejido adiposo. Es una neoplasia benigna que se puede presentar de forma localizada o difusa, que afecta a niños en la primera infancia y que, generalmente, se localiza en el tronco y las extremidades. Estos tumores son poco frecuentes en la edad pediátrica, pero cuando uno de ellos se presenta, constituye un desafío que se debe resolver rápidamente por el riesgo de malignidad que implican otras lesiones neoplásicas, de similares características. El diagnóstico preoperatorio es dificultoso, ya que los métodos por imágenes no aportan información específica que permita diferenciarlos de otros tumores, como los liposarcomas. El diagnóstico definitivo es anatomopalógico y, en casos dudosos, es necesaria la confirmación citogenética. Se presenta el caso de un niño de 14 meses de edad con diagnóstico de lipoblastoma de localización retroperitoneal de gran tamaño. Palabras clave: neoplasias retroperitoneales, lipoblastoma, pediatría.ABSTRACT Lipoblastoma is part of tumors derived from adipose tissue. It is a benign neoplasm that can be localized or diffuse, affecting children in early childhood and usually located in the trunk and extremities. These tumors are uncommon in the pediatric age, but when one of them is present, it is a challenge that we must resolve quickly due to the risk of malignancy that involves other similar neoplastic lesions. The preoperative diagnosis is difficult, because the imaging methods do not provide specific information that allows us to differentiate them from other tumors, such as liposarcomas. The definitive diagnosis is anatomopathological and, in doubtful cases, cytogenetic confirmation is necessary. We present the case of a 14-month-old boy with diagnosis of large sized lipoblastoma of retroperitoneal localization. Lipoblastoma retroperitoneal gigante. Caso clínico Giant retroperitoneal lipoblastoma. Case report INTRODUCCIÓNLos tumores adiposos se clasifican como b e n i g n o s : l i p o m a , l i p o m a h e t e r o t ó p i c o , lipomatosis, hibernoma y variantes de lipoma, como lipoblastoma y lipoblastomatosis (LBS); o malignos: liposarcoma, que es extremadamente raro en la infancia.

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“…Lipoblastoma is a rare, benign neoplasm that consists of immature fat cells at various degrees of maturity and occurs exclusively in childhood, with a male predominance between 1.5 and 3:1 (Chung and Enzinger 1973;Stringel et al 1982). It has a good prognosis, and does not behave aggressively or metastasize, and therefore the treatment of choice is complete but conservative excision (Chung and Enzinger 1973;Mentzel et al 1993;Coffin 1994;Gilbert et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Lipoblastoma Mimicking Myxoid Liposarcoma: A Clinical Report and Literature Review

Nagano

Ohno

Nishimoto

et al. 2011

Tohoku J. Exp. Med.

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Lipoblastoma is an uncommon benign lipomatous tumor, occurring typically in children less than 3 years of age. The magnetic resonance image (MRI) is a useful tool for diagnosis of lipoblastoma; its imaging typically shows high-intensity signals on both T1-weighted (T1-W) and T2 weighted (T2-W) images. Here, we present a 12-year-old female patient with a painless mass on the anterior right shoulder. MRI showed the mass with low-intensity signals on T1-W and high-intensity signals on T2-W images. Because of the atypical age and MRI findings, it was difficult to make a conclusive diagnosis of the tumor as lipoblastoma preoperatively. Histopathological examination of the excised tumor showed spindle-shaped or stellate cells embedded in the myxoid matrix, and a few small irregular clusters of mature fat cells that are separated by connective tissue septa. There were some immature, lipoblast-like cells dispersed. These findings are consistent with lipoblastoma, and myxoid liposarcoma was considered as one of the differential diagnosis. We finally diagnosed the tumor as a lipoblastoma for the reasons that there were many mature fat cells and no atypical cells for a myxoid liposarcoma. The postoperative course was uneventful and no recurrence was observed 5 years after the operation. The patient presented is worthy of note due to the unusual characteristics of the tumor. Even in the case of adolescent or older patients with atypical imaging, lipoblastoma should be considered as one of differential diagnosis.Keywords: lipoblastoma; neoplasm; magnetic resonance imaging; adipose tumor; soft tissue tumor Tohoku J. Exp. Med., 2011, 223 (1), 75-78. © 2011 Tohoku University Medical Press Lipoblastoma is a rare benign soft-tissue childhood tumor occurring most commonly in children less than 3 years of age (Chung and Enzinger 1973;Mentzel et al. 1993), and magnetic resonance image (MRI) is a useful tool for its diagnosis and preoperative evaluation (Reiseter et al. 1999). MRIs of this type of tumor are typically characterized by high-intensity signals on both T1 weighted (T1-W) and T2 weighted (T2-W) images (Letourneau et al. 1993). We report a 12-year-old female patient with lipoblastoma in the shoulder, which was difficult to diagnose preoperatively because of the age and its atypical MRI findings. Meanwhile, the presented tumor showed generally low-intensity signals on T1-W, and high-intensity signals on T2-W images. These findings were not consistent with lipomatous tumor, and finally we made a diagnosis considering all findings obtained. Clinical FindingsA 12-year-old female was referred to our clinic with a 3-month history of a painless mass on the anterior right shoulder. The patient had no history of trauma or constitutional symptoms. Physical examination showed a 6 × 3 cm elastic soft mass on the anteromedial aspect of the right humerus. The mass was non-tender, well circumscribed, and distinct from surrounding tissue, and did not pulsate. The overlying skin showed none of reddening, increased warmth and vein distention...

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Lipoblastoma in infants and children

Cited by 113 publications

References 5 publications

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Fine Needle Aspiration Diagnosis of Lipoblastoma of the Parotid Region

Lipoblastoma retroperitoneal gigante. Caso clínico

Lipoblastoma Mimicking Myxoid Liposarcoma: A Clinical Report and Literature Review

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