Lipoatrophie annulaire des chevilles traitée par autogreffe de tissu graisseux : à propos d’un cas et revue de la littérature

Nguyen-Khac, B.; Leca, Jean‐Baptiste; Carré, Dominique; Coquerel-Béghin, D.; Auquit-Auckbur, I.

doi:10.1016/j.anplas.2015.06.005

Cited by 2 publications

(6 citation statements)

References 14 publications

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“…The inflammatory phase comprises asymmetrical, 4,9,10 rarely unilateral, 11,12 inflammatory nodules or plaques located on the extremities of the lower limbs (ankles, calves, and feet) and is sometimes associated with debilitating symptoms such as muscle pain and cramps 6,7,9,10,12,13 . Triggers such as upper respiratory tract infection, trauma, and friction are sometimes reported, 4,12,14,15 as was the case for one patient in our series. Associated anomalies have been reported during this initial phase, such as inflammatory synovitis, 16,17 bone and ligament edema, 9,18 or prominent tibial growth lines on X‐rays 19 .…”

Section: Discussionmentioning

confidence: 53%

“…ALA generally presents with an initial inflammatory stage and a late atrophic stage. 4,9,10 The inflammatory phase comprises asymmetrical, 4,9,10 rarely unilateral, 11,12 inflammatory nodules or plaques located on the extremities of the lower limbs (ankles, calves, and feet) and is sometimes associated with debilitating symptoms such as muscle pain and cramps. 6,7,9,10,12,13 Triggers such as upper respiratory tract infection, trauma, and friction are sometimes reported, 4,12,14,15 as was the case for one patient in our series.…”

Section: Discussionmentioning

confidence: 99%

“…The histology of ALA shows a non‐specific lobular panniculitis with a dense lymphohistiocytic infiltrate, lipophagy, and perivascular inflammatory infiltrate without vasculitis 5,14‐16 and differs from SPTCL due to the lack of karyorrhexis, necrosis, and lymphocyte phagocytosis by histiocytes 14 . Various associated immunological anomalies have been reported in children with ALA, such as low levels of antinuclear antibodies, anti‐thyroid peroxidase and anti‐thyroglobulin antibodies, 3‐5,9 and an inflammatory syndrome during the early phase 9,13,14,20‐22 . Imaging reveals edema or inflammatory infiltration of the soft tissues during the inflammatory stage, and atrophy of the subcutaneous tissue during the atrophic stage 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Annular lipoatrophy of the ankle (ALA) is a rare acquired lipoatrophic panniculitis first reported in 1953 by Ferreira‐Marques by the name lipoatrophia annularis 1 and then described by Winkelmann as connective tissue panniculitis (CTP), 2 but it would appear that ALA is a more localized form of CTP 3 . It mainly affects children who are otherwise healthy but may present with autoimmune diseases 3‐5 and has a stereotyped presentation, starting with inflammatory nodules or plaques around the ankles which progress into circumferential subcutaneous atrophy within a few months. There is no consensus on treatment, and long‐term outcomes are poorly documented.…”

Section: Introductionmentioning

confidence: 99%

“…Treatment may also play a role in reducing debilitating symptoms, as seen in Patient1, but we cannot exclude the possibility that his cramps may have naturally resolved over the course of the disease. During the stable atrophic phase, the use of reconstructive surgery with autologous fat injection was reported in one child and one adult, with good results 4,8.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Annular lipoatrophy of the ankle: Four new pediatric cases and a review of the literature

Touhouche

Tournier

Lamant

et al. 2021

Pediatric Dermatology

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Annular lipoatrophy of the ankle (ALA) is a rare acquired lipoatrophic panniculitis first reported in 1953 by Ferreira-Marques by the name lipoatrophia annularis 1 and then described by Winkelmann as connective tissue panniculitis (CTP), 2 but it would appear that ALA is a more localized form of CTP. 3 It mainly affects children who are otherwise healthy but may present with autoimmune diseases 3-5 and has a stereotyped presentation, starting with inflammatory nodules or plaques around the ankles which progress into circumferential subcutaneous atrophy within a few months. There is no consensus on treatment, and long-term outcomes are poorly documented. We present four new cases of childhood ALA, including a patient with an extended follow-up of more than 10 years. | C A S E REP ORTSFour children (two boys and two girls), aged between 5 and 9 years, were diagnosed with ALA. All were otherwise healthy. Their characteristics are presented in Table 1. ALA has a classic history starting with inflammatory nodules or plaques around the ankles and calves evolving over months to subcutaneous atrophy. Some had triggering events, such as Patient 1 (Figure 1) who reported the appearance of lesions after wearing a new pair of high-top shoes that may have caused local trauma. All had a classic history of ALA except for Patient 2, who reported no initial inflammatory stage. Only, Patient 1 reported initial debilitating symptoms (severe cramps and myalgia).The lesions were located on the lower extremities for all patients except for Patient 3 (Figure 2), who had mild lesions on the buttocks.

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