Lipoamino acid-based cerasomes for doxorubicin delivery: Preparation and in vitro evaluation

Gileva, Anastasia; Sarychev, G. A.; Kondrya, U.; Mironova, Maria S.; Sapach, Anastasiia Yu.; Selina, O; Буданова, У. А.; Буров, С. В.; Sebyakin, Yu. L.; Марквичева, Елена

doi:10.1016/j.msec.2019.02.111

Cited by 14 publications

(7 citation statements)

References 24 publications

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“…Under laser confocal microscopy, it can be seen that after 4 h, the cell morphology incubated with mixed nanomicelles began to change significantly, and the change in cell viability affected the absorptive capacity of cells, resulting in less cellular uptake of mixed nanomicelles. In this case, the data confirmed that the novel AMF-loaded mixed micelles we prepared can have a toxic effect on cancer cells in a different way compared with most of the micelles (Bernabeu et al, 2016;Cagel et al, 2017;Hu et al, 2017;Ding et al, 2018;Gileva et al, 2019;Shishir et al, 2019). The factors such as cell type and density, particle size, surface modifying ligands, and surface properties can also affect cellular uptake (Wu et al, 2019).…”

Section: Discussionsupporting

confidence: 62%

Preparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles

Xue

Chen

et al. 2020

Drug Delivery

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Amentoflavone (AMF) is a kind of biflavonoids existing in Ginkgo biloba leaves. It has many biological activities, such as antioxidant, anti-inflammatory, anti-bacterial, antiviral, hypoglycemic, anti-tumor and inducing apoptosis. However, its solubility and bioavailability are poor and there are a few studies on it in vivo. In this study, to improve its solubility and bioavailability, the nanomicelles were prepared with TPGS and soluplus as carriers for the first time. The particle size, Zeta potential, encapsulation efficiency, drug loading, stability, cytotoxicity, cellular uptake, and metabolites in rats were studied. Cytotoxicity, cellular uptake, and metabolites in rats of AMF-loaded TPGS/soluplus mixed micelles were compared with those of AMF. As a result, AMF-loaded TPGS/soluplus mixed micelles with a particle size of 67.33 ± 2.01 nm and Zeta potential of À0.84133 ± 0.041405 mV were successfully prepared. The encapsulation efficiency and drug loading of the mixed nanomicelles were 99.18 ± 0.76% and 2.47 ± 0.01%, respectively. The physical and chemical properties of the mixed micelles were stable within 60 d, and the cytotoxicity of the mixed micelles was much greater than that of AMF monomers. Thirty-four kinds of metabolites of AMF were identified in rats. The metabolites were mainly distributed in rat feces. No metabolites were detected in bile and plasma. 14 kinds of metabolites of the mixed micelles in rats were detected, including 11 in feces, 6 in urine, and 3 in plasma, which indicated that the bioavailability of AMF has been improved. And the toxicity to cancer cells was enhanced, which laid a foundation for the development of new drugs.

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Section: Discussionsupporting

confidence: 62%

Preparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles

Xue

Chen

et al. 2020

Drug Delivery

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“…The cerasome concept has been alternatively developed by Sebyakin and Gileva with co-workers who developed an L-aspartate-based cerasome forming lipids which were demonstrated to be able to form cerasomes comparable to the original cerasome forming lipids [273,274]. The aspartate-based framework enables simpler selection of hydrophobic tails, since in the original lipid structure the hydrophobic part is based on an amine that is more laborious to synthesize, while providing the opportunity to impart a cationic group in the structure to enable aqueous solubility as well.…”

Section: Cerasomesmentioning

confidence: 99%

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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Encapsulation of cargoes in nanocontainers is widely used in different fields to solve the problems of their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, and functional activity improvement. This approach is of special importance in biomedicine, since this makes it possible to reduce the limitations of drug delivery related to the toxicity and side effects of therapeutics, their low bioavailability and biocompatibility. This review highlights current progress in the use of lipid systems to deliver active substances to the human body. Various lipid compositions modified with amphiphilic open-chain and macrocyclic compounds, peptide molecules and alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting of organic and inorganic parts. Such nanohybrid platforms include cerasomes, which are considered as alternative nanocarriers allowing to reduce inherent limitations of lipid nanoparticles. Compositions based on mesoporous silica are beginning to acquire no less relevance due to their unique features, such as advanced porous properties, well-proven drug delivery efficiency and their versatility for creating highly efficient nanomaterials. The types of silica nanoparticles, their efficacy in biomedical applications and hybrid inorganic-polymer platforms are the subject of discussion in this review, with current challenges emphasized.

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“…This drawback has been overcome by varying cerasome lipid composition as primary degradation of lipids provides a pore formation in the siloxane network. On this regard, in vitro studies carried out using MCF‐7 with DOX‐loaded cerasomes with optimized lipid composition (a mixture of cerasome‐forming lipoamino acids (CFLA) and dipalmitoylphosphatidylcholine (DPPC) lipid, faster and better accumulation efficiencies as well as higher cytotoxicity levels are found (Gileva et al, ). Additionally, in an attempt to address the pressing demand to find strategies for the delivery of therapeutics, through the blood‐brain barrier (BBB), cerasomes modified with polysorbate 80 (PS 80) for the delivery of curcumin to treat Parkinsons disease (PD), has been reported (N. Zhang, Yan, et al, ).…”

Section: Different Types Of Oinhsmentioning

confidence: 99%

Recent developments in the use of organic–inorganic nanohybrids for drug delivery

Manatunga

Godakanda

Silva

et al. 2019

WIREs Nanomed Nanobiotechnol

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Organic–inorganic nanohybrid (OINH) structures providing a versatile platform for drug delivery with improved characteristics are an area which has gained recent attention. Much effort has been taken to develop these structures to provide a viable treatment options for much alarming diseases such as cancer, bone destruction, neurological disorders, and so on. This review focuses on current work carried out in producing different types of hybrid drug carriers identifying their properties, fabrication techniques, and areas where they have been applied. A brief introduction on understating the requirement for blending organic–inorganic components into a nanohybrid drug carrier is followed with an elaboration given about the different types of OINHs developed currently highlighting their properties and applications. Then, different fabrication techniques are discussed given attention to surface functionalization, one‐pot synthesis, wrapping, and electrospinning methods. Finally, it is concluded by briefing the challenges that are remaining to be addressed to obtain multipurpose nanohybrid drug carriers with wider applicability. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Lipoamino acid-based cerasomes for doxorubicin delivery: Preparation and in vitro evaluation

Cited by 14 publications

References 24 publications

Preparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles

Preparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Recent developments in the use of organic–inorganic nanohybrids for drug delivery

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