Lipids contribute to epigenetic control via chromatin structure and functions

Жданов, Р. И.; Schirmer, Eric C.; Venkatasubramani, Anuroop Venkateswaran; Kerr, Alastair; Mandrou, Elena; Blanco, Giovanny Rodriguez; Kagansky, Alexander

doi:10.14293/s2199-1006.1.sor-life.auxytr.v2

Cited by 3 publications

(3 citation statements)

References 85 publications

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“…According to the growing body of evidences, these metabolic features are common to different types of tumors and are considered now as one of the “hallmarks of cancer” [4, 6, 169]. They provide metabolic plasticity to cancer cells which has an impact on different features such as gene expression [170], epigenetic control [171] and drug resistance [172]. One carbon metabolism provides “building blocks” (nucleotides, certain aminoacids) as well as contributes to epigenetic (SAM for DNA and protein methylation) and redox (glutathione) homeostasis for rapidly proliferating cancer cells.…”

Section: Discussionmentioning

confidence: 99%

One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy

et al. 2017

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Cancer-related metabolism has recently emerged as one of the "hallmarks of cancer". It has several important features, including altered metabolism of glucose and glutamine. Importantly, altered cancer metabolism connects different biochemical pathways into the one fine-tuned metabolic network, which stimulates high proliferation rates and plasticity to malignant cells. Among the keystones of cancer metabolism are one-carbon metabolism and nucleotide biosynthesis, which provide building blocks to anabolic reactions. Accordingly, the importance of these metabolic pathways for anticancer therapy has well been documented by more than fifty years of clinical use of specific metabolic inhibitors -methotrexate and nucleotides analogs. In this review we discuss one-carbon metabolism and nucleotide biosynthesis as common and specific features of many, if not all, tumors. The key enzymes involved in these pathways also represent promising anti-cancer therapeutic targets. We review different aspects of these metabolic pathways including their biochemistry, compartmentalization and expression of the key enzymes and their regulation at different levels. We also discuss the effects of known inhibitors of these pathways as well as the recent data on other enzymes of the same pathways as perspective pharmacological targets.

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Section: Discussionmentioning

confidence: 99%

One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy

et al. 2017

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“…There are different mechanisms through which lipids can regulate gene expression (Zhdanov et al, 2016;Fernandes et al, 2018). First, in vitro experiments suggested that some lipid species, such as oleic acid, may directly bind to DNA (Zhdanov et al, 2002), which could have significant impacts on gene expression but is not currently supported by data obtained under physiological conditions (Fernandes et al, 2018).…”

Section: Lipids and Regulation Of The Transcriptome And Epigenomementioning

confidence: 99%

Lipid Mediated Regulation of Adult Stem Cell Behavior

Clémot

Demarco

Jones

2020

Front. Cell Dev. Biol.

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Adult stem cells constitute an important reservoir of self-renewing progenitor cells and are crucial for maintaining tissue and organ homeostasis. The capacity of stem cells to self-renew or differentiate can be attributed to distinct metabolic states, and it is now becoming apparent that metabolism plays instructive roles in stem cell fate decisions. Lipids are an extremely vast class of biomolecules, with essential roles in energy homeostasis, membrane structure and signaling. Imbalances in lipid homeostasis can result in lipotoxicity, cell death and diseases, such as cardiovascular disease, insulin resistance and diabetes, autoimmune disorders and cancer. Therefore, understanding how lipid metabolism affects stem cell behavior offers promising perspectives for the development of novel approaches to control stem cell behavior either in vitro or in patients, by modulating lipid metabolic pathways pharmacologically or through diet. In this review, we will first address how recent progress in lipidomics has created new opportunities to uncover stem-cell specific lipidomes. In addition, genetic and/or pharmacological modulation of lipid metabolism have shown the involvement of specific pathways, such as fatty acid oxidation (FAO), in regulating adult stem cell behavior. We will describe and compare findings obtained in multiple stem cell models in order to provide an assessment on whether unique lipid metabolic pathways may commonly regulate stem cell behavior. We will then review characterized and potential molecular mechanisms through which lipids can affect stem cell-specific properties, including self-renewal, differentiation potential or interaction with the niche. Finally, we aim to summarize the current knowledge of how alterations in lipid homeostasis that occur as a consequence of changes in diet, aging or disease can impact stem cells and, consequently, tissue homeostasis and repair.

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“…Furthermore nuclear phospholipids are involved in remodeling of chromatin and epigenetic regulation of gene expression. Alterations of lipid quantity can change the functional and physiological state of the cell [2,4,5]. It is possible that quantitative changes in nuclear phospholipids are involved in the molecular mechanisms of action of drugs such as cisplatin and steroid hormones.…”

Section: Introductionmentioning

confidence: 99%

Cisplatin and Progesterone Separate and Joint Action on Rat Thymus Nuclear Phospholipids Composition and Content

Hovhannisyan,

Hakobyan,

Yavroyan

et al. 2023

Proc. YSU B: Chem. Biol. Sci.

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The antitumor agent cisplatin and progesterone separate and joint action on content of total phospholipids and their individual fractions in nuclei from rat thymus cells were investigated. When used separately, cisplatin and progesterone exhibit its own distinctive properties. Cisplatin reduces, and progesterone, on the contrary, increases the content of total phospholipids. When used together, the effects of these drugs are summed up. Thus total phospholipid content of rat thymus cell nuclei increases by 17% after the joint injection of cisplatin and progesterone. These changes have different effects on quantities of individual phospholipid fractions. It is assumed that the effects of cisplatin and progesterone, both in their separate and joint action, can be mediated by quantitative changes in internuclear lipids that in turn can regulate the main functions of the cell nuclei.

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Lipids contribute to epigenetic control via chromatin structure and functions

Cited by 3 publications

References 85 publications

One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy

One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy

Lipid Mediated Regulation of Adult Stem Cell Behavior

Cisplatin and Progesterone Separate and Joint Action on Rat Thymus Nuclear Phospholipids Composition and Content

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