Lipids and testicular function

Abstract

We studied 19 male patients with primary hyperlipoproteinaemia, a control group of 28 healthy men and 44 infertile males before any treatment was undertaken. Spermiogram, seminal biochemical studies, measurements of plasma hormone levels and lipid determinations were carried out. Most hyperlipoproteinaemic patients showed abnormalities in the spermiograms and the mean values were lower than in the controls except for semen volume. Seminal biochemical determinations were normal in the majority and the hormone profile showed some abnormal values, mainly for E2. Lipid abnormalities were more common in azoospermic infertile men and mean lipid levels were higher. Correlation studies suggest that high levels of C and/or Tg are associated with poor semen quality and higher FSH levels. The results of our studies suggest that high lipid levels exert adverse direct effects at the testicular level.

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

“…HDL, a good plasma lipoprotein, is utilized by testicular cells for androgen synthesis [72]. In fact, a good number of HDL receptors are found in the testicular tissue which may be related to its role in the testosterone synthesis [73]. Therefore, in the present study, STZ induced decrease in the HDL level appears to adversely affect the testicular function and it is increased by simultaneous administration of PQQ that maintains its normal level.…”

Testicular immunohistochemical and Ultrastructural changes associated with chronic cholestasis in rats: Effect of ursodeoxycholic acid

“…Besides systemic oxidative stress, conditions correlated with advanced liver diseases, such as portal systemic shunting, dyslipidemia, protein deficiency and micronutrient malabsorption, could also provoke testicular alterations similar to those observed herein [44,[57][58][59][60][61][62][63].…”

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility

“…For example, women with polycystic ovary syndrome have increased cardiovascular disease risk factors compared with controls, including increased total cholesterol (TC), LDL-C, and triglyceride (TG) levels, as well as lower HDL-C levels (63,64). Additionally, men with hypotestosteronemia are reported to have depressed HDL-C levels compared with controls (65,66), and high levels of TC and TG are associated with poor semen quality and azoospermia (67). In one report, a dyslipidemia incidence of 65% was found in a set of 106 men with reproductive concerns (68).…”