Lipids and bariatric procedures Part 2 of 2: scientific statement from the American Society for Metabolic and Bariatric Surgery (ASMBS), the National Lipid Association (NLA), and Obesity Medicine Association (OMA)

Bays, Harold; Kothari, Shanu N.; Azagury, Dan E.; Morton, John M.; Nguyen, Ninh T.; Jones, Peter H.; Jacobson, Terry A.; Cohen, David E.; Orringer, Carl E.; Westman, Eric; Horn, Deborah B.; Scinta, Wendy; Primack, Craig

doi:10.1016/j.soard.2016.01.007

Cited by 46 publications

(52 citation statements)

References 232 publications

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“…This is important because CVD is strongly associated with dyslipidemia and BMI ( 7 , 26 ). Improved lipid measures and clinical remission of dyslipidemia in association with weight loss post-MBS has previously been reported in adults and adolescents ( 8 , 25 , 27 – 29 ). Although percent BMI change was the primary contributor to improvements in LDL-C, non-HDL-C, HDL-C and TG post-MBS, physical activity was associated with further decrease in CVD-related lipids, LDL-C and non-HDL-C.…”

Section: Discussionmentioning

confidence: 63%

Physical Activity Improves Lipid and Weight‐Loss Outcomes After Metabolic Bariatric Surgery in Adolescents with Severe Obesity

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Kaizer

Daniels

et al. 2019

Obesity

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Objective: To test the hypothesis that Physical Activity (PA) improves cardiovascular disease (CVD)-related lipids beyond that associated with weight loss in adolescents with severe obesity, post-metabolic bariatric surgery (MBS). Methods: We used objective StepWatch™ PA data from 108 participants of the Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study from baseline to 3 years post-MBS. Primary outcomes included absolute change in low density lipoprotein (LDL-C) and non-high density lipoprotein (non-HDL-C) from baseline. We adjusted for baseline measurement, visit, surgical procedure, and percent change in iliac waist circumference (IWC) or body mass index (BMI) from baseline in linear regression models using generalized estimating equations. PROC TRAJ in SAS generated optimal activity trajectories based on individual step count. Results: Despite low step counts and slow cadence, differences by activity trajectory were found. Greater absolute decreases in LDL-C and non-HDL-C (−15 mg/dL [95% CI: (−28, −2)], p =0.026 and −15 mg/dL [95% CI: (−28, −1)], p = 0.035), respectively, were associated with more activity (MA). MA was associated with greater resolution of triglycerides, LDL-C and non-HDL-C dyslipidemia and with greater weight loss 3 years post-MBS. Conclusion: More activity in adolescents was associated with improvements in CVD-related lipid measures and weight loss, post-MBS.

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Section: Discussionmentioning

confidence: 63%

Physical Activity Improves Lipid and Weight‐Loss Outcomes After Metabolic Bariatric Surgery in Adolescents with Severe Obesity

Price

Kaizer

Daniels

et al. 2019

Obesity

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“…Weight loss has beneficial effects on lipids and amplifies the benefits of dietary treatment, resulting in a 20% decrease in triglycerides, a 15% reduction in LDL-cholesterol and an 8-10% increase in HDL-cholesterol [65]. Therefore, the large reduction in body fat mass after bariatric surgery leads to beneficial changes in serum lipids (total-cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides), with the greater the body weight loss, the greater the improvement in dyslipidaemia [66,67]. Moreover, bariatric surgery may affect serum lipids by alternative mechanisms, including alteration of lipid metabolism, gastro-intestinal lipid absorption, bile acid metabolism, gut microbiota and gut hormones [66,67].…”

Section: Management Of Co-morbiditiesmentioning

confidence: 99%

“…Therefore, the large reduction in body fat mass after bariatric surgery leads to beneficial changes in serum lipids (total-cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides), with the greater the body weight loss, the greater the improvement in dyslipidaemia [66,67]. Moreover, bariatric surgery may affect serum lipids by alternative mechanisms, including alteration of lipid metabolism, gastro-intestinal lipid absorption, bile acid metabolism, gut microbiota and gut hormones [66,67]. Some bariatric procedures augment the beneficial effects of weight loss by reducing the absorption of cholesterol.…”

Section: Management Of Co-morbiditiesmentioning

confidence: 99%

Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management

et al. 2017

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Bariatric surgery is today the most effective long-term therapy for the management of patients with severe obesity, and its use is recommended by the relevant guidelines of the management of obesity in adults. Bariatric surgery is in general safe and effective, but it can cause new clinical problems and is associated with specific diagnostic, preventive and therapeutic needs. For clinicians, the acquisition of special knowledge and skills is required in order to deliver appropriate and effective care to the post-bariatric patient. In the present recommendations, the basic notions needed to provide first-level adequate medical care to post-bariatric patients are summarised. Basic information about nutrition, management of co-morbidities, pregnancy, psychological issues as well as weight regain prevention and management is derived from current evidences and existing guidelines. A short list of clinical practical recommendations is included for each item. It remains clear that referral to a bariatric multidisciplinary centre, preferably the one performing the original procedure, should be considered in case of more complex clinical situations.

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“…41,42 In a recent lipoprotein kinetic study, we have shown improved TRL metabolism after bariatric surgery (GBP and SG) in nondiabetic, obese, insulin-resistant humans with normolipidemia or mild dyslipidemia. This improvement was manifested by decreased production of VLDL and chylomicrons and increased clearance of VLDL.…”

Section: Discussionmentioning

confidence: 99%

Impact of bariatric surgery on apolipoprotein C-III levels and lipoprotein distribution in obese human subjects

Maraninchi¹,

Padilla²,

Béliard

et al. 2017

Journal of Clinical Lipidology

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BACKGROUND: Elevated apolipoprotein C-III (apoC-III) has been postulated to contribute to the atherogenic dyslipidemia seen in obesity and insulin-resistant states, mainly by impairing plasma triglyceride-rich lipoprotein (TRL) metabolism. Bariatric surgery is associated with improvements of several obesity-associated metabolic abnormalities, including a reduction in plasma triglycerides (TGs) and an increase in plasma high-density lipoprotein cholesterol (HDL-C).OBJECTIVES: We investigated the specific effect of bariatric surgery on apoC-III concentrations in plasma, non-HDL, and HDL fractions in relation to lipid profile parameters evolution.METHODS: A total of 132 obese subjects undergoing bariatric surgery, gastric bypass (n 5 61) or sleeve gastrectomy (n 5 71), were studied 1 month before surgery and 6 and 12 months after surgery.RESULTS: Plasma apoC-III, non-HDL-apoC-III, and HDL-apoC-III concentrations were markedly reduced after surgery and strongly associated with reduction in plasma TG. This decrease was E-mail address: rvalero@mail.ap-hm.fr accompanied by a redistribution of apoC-III from TRL to HDL fractions. In multivariate analysis, plasma apoC-III was the strongest predictor of TG reduction after surgery, and the increase of HDL-C was positively associated with plasma adiponectin and negatively with body mass index.CONCLUSION: Marked reduction of apoC-III and changes in its distribution between TRL and HDL consistent with a better lipid profile are achieved in obese patients after bariatric surgery. These apoC-III beneficial modifications may have implications in dyslipidemia improvement and contribute to cardiovascular risk reduction after surgery.

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Lipids and bariatric procedures Part 2 of 2: scientific statement from the American Society for Metabolic and Bariatric Surgery (ASMBS), the National Lipid Association (NLA), and Obesity Medicine Association (OMA)

Cited by 46 publications

References 232 publications

Physical Activity Improves Lipid and Weight‐Loss Outcomes After Metabolic Bariatric Surgery in Adolescents with Severe Obesity

Physical Activity Improves Lipid and Weight‐Loss Outcomes After Metabolic Bariatric Surgery in Adolescents with Severe Obesity

Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management

Impact of bariatric surgery on apolipoprotein C-III levels and lipoprotein distribution in obese human subjects

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