Lipidic Micro‐ and Nano‐Carriers for Pulmonary Drug Delivery—A State‐of‐the‐Art Review

Rahimpour, Yahya; Hamishehkar, Hamed; Nokhodchi, Ali

doi:10.1002/9781118799536.ch6

Cited by 3 publications

(2 citation statements)

References 88 publications

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“…After oral administration, these are also absorbed by lipoprotein receptors, which are mostly found in the liver. 189…”

Section: Nanoemulsionsmentioning

confidence: 99%

“…Considering its potential features, several researches aimed at improving TB medication have been published. 189 The aforementioned nanocarriers are examples of carriers that can overcome drug resistance and facilitate ATD delivery to MTB infection. As a consequence, medicines that are well known for their beneficial effects can be safely used for effective TB treatment in the form of nanocarriers.…”

Section: Bedaquiline (Bdq) Rifampicin (J774): Macrophage Cell Linesmentioning

confidence: 99%

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Innovative Therapeutic Approaches Based on Nanotechnology for the Treatment and Management of Tuberculosis

Kia¹,

Ruman²,

Pratiwi³

et al. 2023

IJN

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Tuberculosis (TB), derived from bacterium named Mycobacterium tuberculosis, has become one of the worst infectious and contagious illnesses in the world after HIV/AIDS. Long-term therapy, a high pill burden, lack of compliance, and strict management regimens are disadvantages which resulted in the extensively drug-resistant (XDR) along with multidrug-resistant (MDR) in the treatment of TB. One of the main thrust areas for the current scenario is the development of innovative intervention tools for early diagnosis and therapeutics towards Mycobacterium tuberculosis (MTB). This review discusses various nanotherapeutic agents that have been developed for MTB diagnostics, anti-TB drugs and vaccine. Undoubtedly, the concept of employing nanoparticles (NPs) has strong potential in this therapy and offers impressive outcomes to conquer the disease. Nanocarriers with different types were designed for drug delivery applications via various administration methods. Controlling and maintaining the drug release might be an example of the benefits of utilizing a drug-loaded NP in TB therapy over conventional drug therapy. Furthermore, the drug-encapsulated NP is able to lessen dosage regimen and can resolve the problems of insufficient compliance. Over the past decade, NPs were developed in both diagnostic and therapeutic methods, while on the other hand, the therapeutic system has increased. These "theranostic" NPs were designed for nuclear imaging, optical imaging, ultrasound, imaging with magnetic resonance and the computed tomography, which includes both single-photon computed tomography and positron emission tomography. More specifically, the current manuscript focuses on the status of therapeutic and diagnostic approaches in the treatment of TB.

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“…After oral administration, these are also absorbed by lipoprotein receptors, which are mostly found in the liver. 189…”

Section: Nanoemulsionsmentioning

confidence: 99%

Section: Bedaquiline (Bdq) Rifampicin (J774): Macrophage Cell Linesmentioning

confidence: 99%

Innovative Therapeutic Approaches Based on Nanotechnology for the Treatment and Management of Tuberculosis

Kia¹,

Ruman²,

Pratiwi³

et al. 2023

IJN

View full text Add to dashboard Cite

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Oral inhalation for delivery of proteins and peptides to the lungs

Frőhlich

Salar-Behzadi

2021

European Journal of Pharmaceutics and Biopharmaceutics

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Nanoparticle delivery of grape seed-derived proanthocyanidins to airway epithelial cells dampens oxidative stress and inflammation

Castellani

Trapani

Spagnoletta³

et al. 2018

J Transl Med

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BackgroundChronic respiratory diseases, whose one of the hallmarks is oxidative stress, are still incurable and need novel therapeutic tools and pharmaceutical agents. The phenolic compounds contained in grape are endowed with well-recognized anti-oxidant, anti-inflammatory, anti-cancer, and anti-aging activities. Considering that natural anti-oxidants, such as proanthocyanidins, have poor water solubility and oral bioavailability, we have developed a drug delivery system based on solid lipid nanoparticles (SLN), apt to encapsulate grape seed extract (GSE), containing proanthocyanidins.MethodsPlain, 6-coumarin (6-Coum), DiR- and GSE-loaded SLN were produced with the melt-emulsion method. Physicochemical characterization of all prepared SLN was determined by photon correlation spectroscopy and laser Doppler anemometry. MTT assay (spectrophotometry) and propidium iodide (PI) assay (cytofluorimetry) were used to assess cell viability. Flow cytometry coupled with cell imaging was performed for assessing apoptosis and necrosis by Annexin V/7-AAD staining (plain SLE), cell internalization (6-Coum-SLN) and reactive oxygen species (ROS) production (SLN-GSE). NF-κB nuclear translocation was studied by immunofluorescence. In vivo bio-imaging was used to assess lung deposition and persistence of aerosolized DiR-loaded SLN.ResultsPlain SLN were not cytotoxic when incubated with H441 airway epithelial cells, as judged by both PI and MTT assays as well as by apoptosis/necrosis evaluation. 6-Coum-loaded SLN were taken up by H441 cells in a dose-dependent fashion and persisted into cells at detectable levels up to 16 days. SLN were detected in mice lungs up to 6 days. SLN-GSE possessed 243 nm as mean diameter, were negatively charged, and stable in size at 37 °C in Simulated Lung Fluid up to 48 h and at 4 °C in double distilled water up to 2 months. The content of SLN in proanthocyanidins remained unvaried up to 2 months. GSE-loaded SLN determined a significant reduction in ROS production when added 24–72 h before the stimulation with hydrogen peroxide. Interestingly, while at 24 h free GSE determined a higher decrease of ROS production than SLN-GSE, the contrary was seen at 48 and 72 h. Similar results were observed for NF-κB nuclear translocation.ConclusionsSLN are a biocompatible drug delivery system for natural anti-oxidants obtained from grape seed in a model of oxidative stress in airway epithelial cells. They feature stability and long-term persistence inside cells where they release proanthocyanidins. These results could pave the way to novel anti-oxidant and anti-inflammatory therapies for chronic respiratory diseases.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1509-4) contains supplementary material, which is available to authorized users.

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Lipidic Micro‐ and Nano‐Carriers for Pulmonary Drug Delivery—A State‐of‐the‐Art Review

Cited by 3 publications

References 88 publications

Innovative Therapeutic Approaches Based on Nanotechnology for the Treatment and Management of Tuberculosis

Innovative Therapeutic Approaches Based on Nanotechnology for the Treatment and Management of Tuberculosis

Oral inhalation for delivery of proteins and peptides to the lungs

Nanoparticle delivery of grape seed-derived proanthocyanidins to airway epithelial cells dampens oxidative stress and inflammation

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