Lipid vesicular nanocarrier: Quick encapsulation efficiency determination and transcutaneous application

Zhang, Yibang; Ng, Weibeng; Feng, Xue; Cao, Fangying; Xu, Huaxi

doi:10.1016/j.ijpharm.2016.11.011

Cited by 35 publications

(13 citation statements)

References 26 publications

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“…However, in vivo immunization studies were not performed. Zhang et al compared OVA-and saponin-loaded ethosomes, liposomes, and transfersomes as regards their immunization potency in mice (65). In vivo immunization experiments revealed the highest anti-OVA IgG titers for immunization with ethosomes compared with liposomal or transfersomal TCI.…”

Section: Passive Delivery Methodsmentioning

confidence: 99%

Current Progress in Particle-Based Systems for Transdermal Vaccine Delivery

et al. 2020

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Transcutaneous immunization (TCI) via needle-free and non-invasive drug delivery systems is a promising approach for overcoming the current limitations of conventional parenteral vaccination methods. The targeted access to professional antigen-presenting cell (APC) populations within the skin, such as Langerhans cells (LCs), various dermal dendritic cells (dDCs), macrophages, and others makes the skin an ideal vaccination site to specifically shape immune responses as required. The stratum corneum (SC) of the skin is the main penetration barrier that needs to be overcome by the vaccine components in a coordinated way to achieve optimal access to dermal APC populations that induce priming of T-cell or B-cell responses for protective immunity. While there are numerous approaches to penetrating the SC, such as electroporation, sono-or iontophoresis, barrier and ablative methods, jet and powder injectors, and microneedle-mediated transport, we will focus this review on the recent progress made in particle-based systems for TCI. This particular approach delivers vaccine antigens together with adjuvants to perifollicular APCs by diffusion and deposition in hair follicles. Different delivery systems including nanoparticles and lipid-based systems, for example, solid nano-emulsions, and their impact on immune cells and generation of a memory effect are discussed. Moreover, challenges for TCI are addressed, including timely and targeted delivery of antigens and adjuvants to APCs within the skin as well as a deeper understanding of the ill-defined mechanisms leading to the induction of effective memory responses.

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Section: Passive Delivery Methodsmentioning

confidence: 99%

Current Progress in Particle-Based Systems for Transdermal Vaccine Delivery

et al. 2020

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“…Taking advantage of the deformable property of transfersomes and ethosomes, modification of lipid vesicles with the cationic lipids stearylamine or octadecylamine can promote potent immune responses in TCI. Skin treatment such as microneedle puncture can further facilitate the penetration of cationic vesicles‐vaccine complexes into the epidermis …”

Section: Advanced Technologies For Transcutaneous Gene Deliverymentioning

confidence: 99%

Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination

Sun

Zeng

Huang

2019

The Journal of Gene Medicine

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Therapeutic vaccination is a promising strategy for the immunotherapy of cancers. It eradicates cancer cells by evoking and strengthening the patient's own immune system. Because of the easy access and sophisticated immune networks, the skin becomes an ideal target organ for vaccination. Genetic vaccines have been widely investigated, with the advantages of the delivery of multiple antigens and a lower cost for production compared to protein/peptide vaccines. This review summarizes the advances made with respect to the transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination and also gives a brief description of the immunological milieu of the skin and the importance of dendritic cell‐targeting in vaccine delivery, as well as the technologies that aim to facilitate antigen delivery and modulate antigen‐presenting cells, thus improving cellular responses. The applications of genetic vaccines encoding tumor antigens delivered through the skin route, both in preclinical and clinical trials, are outlined.

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“…The second group malleable liposomes generally called ethosomes are made from phospholipids with ethanol. Some recent findings proved that ethosomes are more effective transdermal carriers than deformable liposomes [6]. Ethosomes were first described by Touitou in 1996 as a skin permeation enhancing system, which is formed from phospholipids in the presence of water and ethanol.…”

Section: Introductionmentioning

confidence: 99%

Nanosized ethanol based malleable liposomes of cytarabine to accentuate transdermal delivery: formulation optimization,in vitroskin permeation andin vivobioavailability

Raj

Ram

2018

Artificial Cells, Nanomedicine, and Biotechnology

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Cytarabine is a pyrimidine nucleoside analog used predominantly for acute myeloid leukemia (AML) and also for other indications, including acute lymphocytic leukemia, chronic myelogenous leukemia, and lymphoma by parenteral route due to its low oral bioavailability. Parenteral administration requires constant plasma level, monitoring for its fluctuation and poor patients compliances. Hence the objective of this work is to construct optimized nanosized malleable liposomes of cytarabine to accentuate transdermal delivery of drug to circumvent previously mentioned drawbacks. We also investigated its characteristics and therapeutic efficiency and attempted to systematically explore the penetration enhancing property. Well characterized ethanolic liposomes were also biologically tested for dermatological safety and systemic bioavailability. Ethanolic liposomes were found to be spherical having nanometric size with low polydispersity and high encapsulation efficiency. Skin permeation and deposition studies revealed significant enhancement. In vivo, skin irritation study of developed formulation showed no erythema or scaling vis-à-vis the liposomes. Blood profile of this novel formulation indicated lower lag time with the high amount of drug within 3-12 h after transdermal administration demonstrating the enhanced percutaneous penetration of cytarabine with no erythema, thus leading to patient's compliance by alternative delivery of drug for the treatment of leukemia.

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Lipid vesicular nanocarrier: Quick encapsulation efficiency determination and transcutaneous application

Cited by 35 publications

References 26 publications

Current Progress in Particle-Based Systems for Transdermal Vaccine Delivery

Current Progress in Particle-Based Systems for Transdermal Vaccine Delivery

Transcutaneous delivery of DNA/mRNA for cancer therapeutic vaccination

Nanosized ethanol based malleable liposomes of cytarabine to accentuate transdermal delivery: formulation optimization,in vitroskin permeation andin vivobioavailability

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