Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1/Th2 bias in the immune response and protection against infection

Mann, J. Adin; Shakir, Eisin; Carter, Katharine C.; Mullen, Alexander B.; Alexander, James; Ferro, Valerie A.

doi:10.1016/j.vaccine.2009.03.040

Cited by 153 publications

(106 citation statements)

References 29 publications

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“…The lipid mixture was then homogenized followed by the addition of bile salt solution to form dispersion containing empty vesicles that was homogenized. Thereafter, the antigen buffered solution was added to the homogenate, and protein entrapment was achieved by further homogenization (Gebril et al, 2014) or several freeze-thaw cycles (Mann et al, 2009). This method was used to entrap influenza A antigen (Gebril et al, 2014) and gonadotropinreleasing hormone (GnRH) immunogens (Gebril et al, 2014) to bilosomes.…”

Section: Hot Homogenization Methodsmentioning

confidence: 99%

“…Bilosomes address these challenges by offering several advantages for oral vaccine delivery. It is postulated that bilosomes protect the vaccine antigen enclosed within the lipid bilayer from premature release and/or degradation in the hostile environment of GI tract (Mann et al, 2006(Mann et al, , 2009Shukla et al, 2008Shukla et al, , 2010aShukla et al, ,b, 2011. Using radiolabeled I-125 insulin entrapped in bilosomes, Mann et al (2006) confirmed the aforementioned and proved that , 1992;Neutra & Kozlowski, 2006;Jain et al, 2011).…”

Section: Bile Salts-containing Liposomes (Bs-liposomes)mentioning

confidence: 97%

“…Several research groups have demonstrated the potential of utilizing bilosomes in facilitating successful oral vaccine delivery (Mann et al, 2006(Mann et al, , 2009Shukla et al, 2008Shukla et al, , 2010aShukla et al, ,b, 2011. Schematic illustrations of different types of bilosomes are depicted in Figure 5.…”

Section: Bile Salts-containing Liposomes (Bs-liposomes)mentioning

confidence: 99%

“…Additional mechanisms, such as direct intracellular delivery of antigens through phagocytosis of particles have also been proposed to explain the potent immunological adjuvant activity of bilosomes (Mann et al, 2009). Schematic illustration of the mechanisms of immune response associated with bilosomes is presented in Figure 6.…”

Section: Bile Salts-containing Liposomes (Bs-liposomes)mentioning

confidence: 99%

“…Particle size of BS-vesicles exerts substantial impact on their in vitro and in vivo performances (Sun et al, 2008;Mann et al, 2009). Analytical instruments constructed on dynamic light scattering principle basis, i.e.…”

Section: In Vitro Characterizations and Variables Influencing Bs-vesimentioning

confidence: 99%

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Bile salts-containing vesicles: promising pharmaceutical carriers for oral delivery of poorly water-soluble drugs and peptide/protein-based therapeutics or vaccines

Aburahma¹

2014

Drug Delivery

103

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Most of the new drugs, biological therapeutics (proteins/peptides) and vaccines have poor performance after oral administration due to poor solubility or degradation in the gastrointestinal tract (GIT). Though, vesicular carriers exemplified by liposomes or niosomes can protect the entrapped agent to a certain extent from degradation. Nevertheless, the harsh GIT environment exemplified by low pH, presence of bile salts and enzymes limits their capabilities by destabilizing them. In response to that, more resistant bile salts-containing vesicles (BS-vesicles) were developed by inclusion of bile salts into lipid bilayers constructs. The effectiveness of orally administrated BS-vesicles in improving the performance of vesicles has been demonstrated in researches. Yet, these attempts did not gain considerable attention. This is the first review that provides a comprehensive overview of utilizing BS-vesicles as a promising pharmaceutical carrier with a special focus on their successful applications in oral delivery of therapeutic macromolecules and vaccines. Insights on the possible mechanisms by which BSvesicles improve the oral bioavailability of the encapsulated drug or immunological response of entrapped vaccine are explained. In addition, methods adopted to prepare and characterize BSvesicles are described. Finally, the gap in the scientific researches tackling BS-vesicles that needs to be addressed is highlighted.

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Section: Hot Homogenization Methodsmentioning

confidence: 99%

Section: Bile Salts-containing Liposomes (Bs-liposomes)mentioning

confidence: 97%

Section: Bile Salts-containing Liposomes (Bs-liposomes)mentioning

confidence: 99%

Section: Bile Salts-containing Liposomes (Bs-liposomes)mentioning

confidence: 99%

Section: In Vitro Characterizations and Variables Influencing Bs-vesimentioning

confidence: 99%

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Bile salts-containing vesicles: promising pharmaceutical carriers for oral delivery of poorly water-soluble drugs and peptide/protein-based therapeutics or vaccines

Aburahma¹

2014

Drug Delivery

103

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Selection of Optimal Adjuvants and Product Factors that Affect Vaccine Immunogenicity

Wang

Singh

2011

Development of Vaccines

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Modulation of Immune Responses by Particulate Materials

2016

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Many biomaterials that are in both preclinical and clinical use are particulate in nature and there is a growing appreciation that the physicochemical properties of materials have a significant impact on their efficacy. The ability of particulates to modulate adaptive immune responses has been recognized for the past century but it is only in recent decades that a mechanistic understanding of how particulates can regulate these responses has emerged. It is now clear that particulate characteristics including size, charge, shape and porosity can influence the scale and nature of both the innate and adaptive immune responses. The potential to tailor biomaterials in order to regulate the type of innate immune response induced, offers significant opportunities in terms of designing systems with increased immune-mediated efficacy.

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Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1/Th2 bias in the immune response and protection against infection

Cited by 153 publications

References 29 publications

Bile salts-containing vesicles: promising pharmaceutical carriers for oral delivery of poorly water-soluble drugs and peptide/protein-based therapeutics or vaccines

Bile salts-containing vesicles: promising pharmaceutical carriers for oral delivery of poorly water-soluble drugs and peptide/protein-based therapeutics or vaccines

Selection of Optimal Adjuvants and Product Factors that Affect Vaccine Immunogenicity

Modulation of Immune Responses by Particulate Materials

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