Selection of Optimal Adjuvants and Product Factors that Affect Vaccine Immunogenicity

Wang, Wei; Singh, Manmohan

doi:10.1002/9781118023648.ch13

Cited by 1 publication

(2 citation statements)

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“…Wang and Singh interpreted the lack of approval of novel and more efficient adjuvants to the basic dogma in vaccinology: a single adjuvant should be used unless it is not effective, that is, keep it simple and stupid. 129 In the forthcoming years, this dogma will have to give way to the hybrid biomimetic adjuvants which are already revealing their superior performance as discussed in the last section of this chapter. For vaccines, targeting means delivering the antigen to the lymph nodes, antigenpresenting cells (APC) or B-cells, and within cells lysosome or cytoplasm.…”

Section: Nanomedicines Based On Biocompatible Polymersmentioning

confidence: 96%

“…128 Wang and Singh comprehensively reviewed the literature on the selection of optimal adjuvants for vaccines. 129 Because of the limited adjuvant effect of aluminum salts which induce only a Th2 response, 130 other nonaluminum adjuvants (often not approved by the FDA in the U.S.) have been searched and tried extensively over the last 20 years. 131,132 Among these, polymeric particles made of biocompatible polymers such as polylactic acid (PLA), poly(lactide-co-glycolide) acid (PLGA), 133 chitosan, 134 poly(γ-glutamic acid) (γ-PGA), 135 and starch.…”

Section: Nanomedicines Based On Biocompatible Polymersmentioning

confidence: 99%

See 1 more Smart Citation

Biomimetic Systems in Nanomedicine

Carmona-Ribeiro¹

2014

Frontiers in Nanobiomedical Research

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Mimicking Nature has been a major source of inspiration for producing novel pharmaceutical formulations with improved therapeutic index and reduced toxicity. In Nature, the self-assembly of biomolecules driven by intermolecular interactions leads to highly functional, nanosized biological machines. Novel directions for drug and vaccine delivery to cure or prevent disease somehow have to copy Mother Nature wisdom. In this chapter, smart nanocarriers produced from the self-assembly of biocompatible polymers, lipids or hybrid nanoparticles (NPs) are presented and some of their applications in antimicrobial chemotherapy, drug and vaccine delivery discussed. Self-Assembly and Intermolecular InteractionsWeak intermolecular interactions are important for the rational design of novel biomimetic materials. Main weak interactions are the van der Waals interaction (ion-dipole, dipole-dipole, dipole-induced dipole interactions, induced-dipole induced-dipole), the electrostatic interaction, the hydrogen bonds, the hydrophobic interactions and the steric repulsion. 1,2 The weak but cooperative hydrogen bonding between the two strands of double-stranded DNA is a wise approach used by Nature to keep the strands together without hampering replication and transcription. 3 The repulsion between nonpolar Handbook of Nanobiomedical Research Downloaded from www.worldscientific.com by UNIVERSITY OF BIRMINGHAM LIBRARY -INFORMATION SERVICES on 03/21/15. For personal use only.

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Section: Nanomedicines Based On Biocompatible Polymersmentioning

confidence: 96%