Lipid Profiles in Dioxin-Exposed Workers

Walker, AnneE.; Martin, J.V.

doi:10.1016/s0140-6736(79)90929-2

Cited by 36 publications

(9 citation statements)

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“…The symptom of a loss of adipose tissue and body mass, along with elevated serum lipid profiles, is known as wasting syndrome. A similar change in lipid profiles has also been found in dioxin-exposed humans [6,7]. Among dioxins, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most toxic congener.…”

Section: Introductionsupporting

confidence: 60%

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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells

Hsu

Tsou

Chao

et al. 2010

Journal of Hazardous Materials

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Section: Introductionsupporting

confidence: 60%

“…Studies in humans [6,7] and various animals [8,9,11,12] have revealed the association between TCDD exposure and the lipid irregularity. Lipolysis is a key factor in the adverse metabolic consequences observed in subjects with higher levels of visceral fat accumulation [42].…”

Section: Discussionmentioning

confidence: 99%

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells

Hsu

Tsou

Chao

et al. 2010

Journal of Hazardous Materials

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“…Case reports of TCDD-exposed individuals have described myocarditis (9), myocardial infarctions (10,11), ectasia of the coronary arteries (12), and rapidly progressive atherosclerosis (13,14). Four mortality studies of TCDD-exposed cohorts reported significantly elevated risks for cardiovascular disease mortality (15)(16)(17)(18), whereas several others have not observed such elevations (19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cardiovascular Outcomes among U.S. Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Calvert¹,

Wall²,

Sweeney³

et al. 1998

Environmental Health Perspectives

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Some animal studies and some human studies suggest that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) may be associated with adverse effects on the cardiovascular system. As part of a cross-sectional medical study comparing workers employed 15 years earlier in the manufacture of 2,4,5-trichlorophenol or one of its derivatives at two U.S. chemical plants with an unexposed comparison group, we examined the association between TCDD exposure and various cardiovascular outcomes. A total of 281 workers and 260 unexposed referents participated. The workers had substantial exposure to TCDD, as demonstrated by significantly elevated mean serum TCDD concentration of 220 pg/g of lipid, compared with 7 pg/g of lipid among the referents. No significant association was found between TCDD exposure and any of the cardiovascular outcomes including myocardial infarction, angina, cardiac arrhythmias, hypertension, and abnormal peripheral arterial flow. Although our study had sufficient statistical power to detect an elevated risk for cardiac arrhythmias, hypertension, and abnormal peripheral arterial flow, it had low power (approximately 50%) to detect an elevated risk for myocardial infarction and angina. Our review of the literature suggests that our negative findings are consistent with those from other cross-sectional medical studies. Although several mortality studies of TCDD-exposed cohorts found significantly increased risks for cardiovascular disease mortality, similar increased risks were not observed in other mortality studies. The data available do not provide definitive conclusions but indicate that further examination of the association between TCDD exposure and cardiovascular disease should be pursued.Environ Health Perspect 1 06(Suppl 2):635-643 (1998). http://ehpnetl.niehs.nih.gov/docs/1998/Suppl-2/ 635-643calvert/abstract.html

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“…(9)(10)(11)(12)(13) Chemicals stored in adipose and other tissues pose a continuing physiological and psychological threat to human health. Dioxin has been associated with ischemic vascular disease (14) and with other physiological as well as psychological effects as long as ten years after initial exposure. (15) Oncological studies have shown a significant association between PCB and DDE levels in fat and increased cancer incidence.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a detoxification regimen for fat stored xenobiotics

et al. 1982

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A detoxification regimen has been found to be safe for use by individuals exposed to recreational (abused) and medical drugs, patent medicines, occupational and environmental chemicals Patients with high blood pressure had a mean reduction of 30.8 mm systolic, 23.3 mm diastolic. Cholesterol level mean reduction was 19.5 mg/100ml, while triglycerides did not change. Medical complications associated with the program were rare, occuring in less than three percent of the subjects. The program resulted in improvements in psychological test scores. The mean increase in Wechsler Adult Intelligence Scale IQ was 6.7 points. High Minnesota Multiphasic Personality Inventory profiles decreased on the third scale (10.7), the fourth scale (8.0), the fifth scale (4.5) and the sixth scale (8.0). The decrease in the fourth scale suggests hope for sociopaths, a group with fourth scale scores not improved by National Institute for Mental Health or Narcotic Addict Rehabilitation Act inpatient programs.

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Lipid Profiles in Dioxin-Exposed Workers

Cited by 36 publications

References 1 publication

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells

Evaluation of Cardiovascular Outcomes among U.S. Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Evaluation of a detoxification regimen for fat stored xenobiotics

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