Lipid profiles as potential mediators linking body mass index to osteoporosis among Chinese adults: the Henan Rural Cohort Study

Wu, Du; Qiao, Dou; Zhang, X.; Zhang, H. Q.; Luo, Zhicheng; Wang, Y.; Pan, Jianwen; Wang, C.

doi:10.1007/s00198-019-04878-y

Cited by 15 publications

(11 citation statements)

References 37 publications

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“…High education level and income might indicate higher socioeconomic status that demonstrated less probability of osteoporosis 32. Furthermore, the present study indicated that participants with higher BMI were less likely to have osteoporosis (obesity was negatively correlated with osteoporosis), and similar results were also reported in previous studies 33–36. It should be noted that a previous study has shown that the beneficial effect on BMD of increasing BMI exists up to 35 kg/m 2 , and a BMI higher than 35 kg/m 2 is not associated with further increase in BMD 37.…”

Section: Discussionsupporting

confidence: 88%

Gender-specific prevalence and influencing factors of osteopenia and osteoporosis in Chinese rural population: the Henan Rural Cohort Study

Qiao

Liu

et al. 2020

BMJ Open

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ObjectiveThe aims of this study were to describe distributions of the prevalence of osteopenia and osteoporosis and identify the potential risk factors by gender in a Chinese rural population.DesignA cross-sectional survey.Setting and participantsA total of 8475 participants (18–79 years) were obtained from the Henan Rural Cohort Study. Bone mineral density (BMD) of the calcaneus for each individual was measured by ultrasonic bone density apparatus. Logistic regression models were used to evaluate associations of potential risk factors with prevalence of osteopenia and osteoporosis. Furthermore, a meta-analysis of prevalence of osteoporosis which included eight studies was conducted to confirm this study results.ResultsThe mean of BMD were 0.42 and 0.32 g/cm2for men with osteopenia and osteoporosis (p<0.001), as well as 0.40 and 0.30 g/cm2(p<0.001) for women with osteopenia and osteoporosis, respectively. The overall age-standardised prevalence of osteopenia and osteoporosis were 42.09% and 11.76% in all participants. The age-standardised prevalence of osteopenia in men (45.98%) was significantly higher than that in women (39.73%), whereas the age-standardised prevalence of osteoporosis in men (7.82%) was lower than that in women (14.38%). Meta-analysis results displayed pooled prevalence of osteoporosis of 18.0% (10.1%–25.8%) in total sample, 7.7% (5.7%–9.7%) in men and 22.4% (17.1%–27.6%) in women. Multivariable logistic regression models showed that ageing, women, low education level or income, drinking or underweight was related to increased risk for osteopenia or osteoporosis.ConclusionsAbout one-sixth of the participants suffered osteoporosis in rural China, and the prevalence in women was higher than men. Although the results were lower than that of meta-analysis, osteoporosis still accounts for huge burden of disease in rural population due to limited medical service and lack of health risk awareness rather than urban area.Trial registration numberChinese Clinical Trial Registry (ChiCTR-OOC-15006699; Pre-results).

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Section: Discussionsupporting

confidence: 88%

Gender-specific prevalence and influencing factors of osteopenia and osteoporosis in Chinese rural population: the Henan Rural Cohort Study

Qiao

Liu

et al. 2020

BMJ Open

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“…Besides, literature reported visceral adiposity measured by visceral fat index (VFI) was deleterious to bone microarchitecture [13,15]. However, previous researches on the association between adiposity and bone tended to examine only by a single adiposity index in the previous studies including our research; it remains unclear that the overall effect of adiposity on bone health using different adiposity indices [11,16,17]. In addition, many people live in rural regions, where it is a hotspot of the incidence of osteoporosis due to poor economic status and medical resource.…”

Section: Introductionmentioning

confidence: 80%

Adiposity reduces the risk of osteoporosis in Chinese rural population: the Henan rural cohort study

et al. 2020

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Background: Adiposity plays a crucial role in the risk of osteoporosis. However, the impact of body fat distribution on the skeleton is contentious. The study was designed to explore the association of various adiposity indices with estimated bone mineral density (BMD) and the risk of osteoporosis based on body mass index (BMI), body fat percentage (BFP), waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), and visceral fat index (VFI). Methods: A total of 8475 subjects derived from the Henan Rural Cohort Study were analyzed. The estimated BMD of study participants were measured by calcaneal quantitative ultrasound (QUS). Linear regression and binary logistic regression were performed to estimate the association of adiposity and the outcomes. Results: The mean age of the study participants was 55.23 ± 11.09 years and 59.61% were women. The crude and age-standardized prevalence of high osteoporosis risk was 16.24 and 11.82%. Per unit increment in adiposity indices was associated with 0.005-0.021 g/cm 2 increase in estimated BMD. The adjusted odds ratios (95% confidence interval) for high osteoporosis risk in per 1 SD increase of WC, WHR, WHtR, BMI, BFP, and VFI were 0.820 (0.748, 0.898), 0.872 (0.811, 0.938), 0.825 (0.765, 0.891), 0.798 (0.726, 0.878), 0.882 (0.800, 0.972), and 0.807 (0.732, 0.889), respectively. Stratified analyses indicated greater effects on individuals aged 55 years or older. Conclusions: The adiposity indices have an inverse association with the risk of osteoporosis among Chinese rural population, especially in the elderly.

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“…Besides, literature reported visceral adiposity measured by visceral fat index (VFI) was deleterious to bone microarchitecture [13,15]. However, previous researches on the association between adiposity and bone tended to examine only a single adiposity index in the previous studies including our research; it remains unclear about the overall effect of adiposity on bone health using different adiposity indices [11,[16][17]. In addition, many people live in rural regions, where it is a hotspot of the incidence of osteoporosis due to poor economic status and medical resource.…”

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confidence: 85%

Adiposity reduces the risk of osteoporosis in Chinese rural population: the Henan Rural Cohort Study

Tian

Pan

Qiao

et al. 2020

Preprint

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Background: Adiposity plays a crucial role in the risk of osteoporosis. However, the impact of body fat distribution on the skeleton is contentious. The study was designed to explore the association of various adiposity indices on estimated bone mineral density (BMD) and the risk of osteoporosis based on body mass index (BMI), body fat percentage (BFP), waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), and visceral fat index (VFI). Methods: A total of 8475 subjects derived from the Henan Rural Cohort Study were analyzed. The estimated BMD of study participants were measured by calcaneal quantitative ultrasound (QUS). Linear and binary logistic regression was performed to estimate the association of adiposity and the outcomes. Results: The mean age of the study participants was 55.23 ± 11.09 years and 59.61% were women. The crude and age-standardized prevalence of high risk for osteoporosis was 16.24% and 11.82%. Per unit increment in adiposity indices was associated with 0.005-0.021 g/cm2 increase in estimated BMD. The adjusted odds ratios (95% confidence interval) for high osteoporosis risk in per 1 SD increase of WC, WHR, WHtR, BMI, BFP, and VFI were 0.820 (0.748, 0.898), 0.872 (0.811, 0.938), 0.825 (0.765, 0.891), 0.798 (0.726, 0.878), 0.882 (0.800, 0.972), and 0.807 (0.732, 0.889), respectively. Stratified analyses indicated greater effects on individuals aged 55 years or more. Conclusions: The adiposity indices have an inverse association with the risk of osteoporosis among Chinese rural population, especially in the elderly. Keywords: Adiposity; Bone mineral density; Osteoporosis; Rural population

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Lipid profiles as potential mediators linking body mass index to osteoporosis among Chinese adults: the Henan Rural Cohort Study

Cited by 15 publications

References 37 publications

Gender-specific prevalence and influencing factors of osteopenia and osteoporosis in Chinese rural population: the Henan Rural Cohort Study

Gender-specific prevalence and influencing factors of osteopenia and osteoporosis in Chinese rural population: the Henan Rural Cohort Study

Adiposity reduces the risk of osteoporosis in Chinese rural population: the Henan rural cohort study

Adiposity reduces the risk of osteoporosis in Chinese rural population: the Henan Rural Cohort Study

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