Lipid Profiles, Alopecia, and Coronary Disease: Any Relationship?

Guzzo, Cynthia; Margolis, David J.; Johnson, Joseph R.

doi:10.1111/j.1524-4725.1996.tb00353.x

Cited by 16 publications

(22 citation statements)

References 3 publications

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“…However, in our study we did not find significant differences in HDL-C values between men with AGA and the control group. Guzzo et al (9) evaluated lipid levels in men with Ebling degree III compared witb randomly obtained serum lipid profiles of age-matched men referring to the reference laboratory. Although no statistically significant difference was measured in lipid indices between AGA patients and controls, theirfinding is questioned because of confounding factors affecting serum lipid profiles (secondary hyperlipidaemia and familial hyperlipidaemia) were ignored.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Dyslipidaemia in Men and Woman with Androgenic Alopecia

et al. 2010

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Several studies have analyzed the relationship between androgenetic alopecia and cardiovascular disease (mainly heart disease). However few studies have analyzed lipid values in men and women separately. This case-control study included 300 patients consecutively admitted to an outpatient clinic, 150 with early onset androgenetic alopecia (80 males and 70 females) and 150 controls (80 males and 70 females) with other skin diseases. Female patients with androgenic alopecia showed significant higher triglycerides values (123.8 vs 89.43 mg/dl, p = 0.006), total cholesterol values (196.1 vs 182.3 mg/dl, p = 0.014), LDL-C values (114.1 vs 98.8 mg/dl, p = 0.0006) and lower HDL-C values (56.8 vs 67.7 mg/dl, p <0.0001) versus controls respectively. Men with androgenic alopecia showed significant higher triglycerides values (159.7 vs 128.7 mg/dl, p = 0.04) total cholesterol values (198.3 vs 181.4 mg/dl, p = 0.006) and LDL-C values (124.3 vs 106.2, p = 0.0013) versus non-alopecic men. A higher prevalence of dyslipidemia in women and men with androgenic alopecia has been found. The elevated lipid values in these patients may contribute, alongside other mechanisms, to the development of cardiovascular disease in patient with androgenic alopecia.

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Section: Discussionmentioning

confidence: 99%

A Comparative Study of Dyslipidaemia in Men and Woman with Androgenic Alopecia

et al. 2010

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“…8,19,25 In contrast, Guzzo et al found no statistically significant difference in lipid indices of cases and controls. 26 The elevated lipid values in androgenetic alopecia patients may contribute, alongside other mechanisms, to the development of cardiovascular disease (CVD). 27,28 In present study the mean values of fasting blood glucose was higher in cases as compared to controls, and the prevalence of impaired fasting glucose (IFG) (>100mg/dl) was found statistically significantly higher in cases (15%) as compared to controls (3%) (P=0.0052).…”

Section: Discussionmentioning

confidence: 99%

Severe androgenetic alopecia as a maker of metabolic syndrome in male patients of androgenetic alopecia: a hospital based case control study

Tilwani

Dogra

et al. 2017

Int J Res Med Sci

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Background: Several previous studies have investigated the association between androgenetic alopecia (AGA) and metabolic syndrome (MS), with inconsistent results. Objectives of the study were to study the prevalence of metabolic syndrome in male patients of androgenetic alopecia and compare with control population and study the relationship of metabolic syndrome with different grades of AGA.Methods: This prospective hospital based case control study included 100 new clinically diagnosed males of androgenetic alopecia, and age and sex matched control group. Assessment for presence of various components of metabolic syndrome was done following a uniform protocol in cases and controls. AGA was classified as per Hamilton –Narwood classification, grade I to III was classified as mild –moderate and grade IV and higher as severe AGA.Results: Of the 100 male AGA patients (age range 21-50, mean 34.49), 36 had grade II AGA, 24 had grade III AGA, 20 had grade IV AGA, 15 had grade V AGA and 5 had grade VI AGA. Among AGA patients, 60 of patients had mild-moderate AGA and 40 patients had severe AGA. Metabolic syndrome was statistically significantly more common in patients with AGA compared to controls. Among patients of AGA, metabolic syndrome was statistically significantly present in severe AGA compared to mild-moderate AGA. Among the evaluated parameters, like blood pressure, fasting blood sugar, dyslipedemia, abdominal obesity, all were significantly more common in AGA patients compared to controls except abdominal obesity.Conclusions: In the present study, metabolic syndrome was found to be 4.6 times more common in patients of androgenetic alopecia as compared to controls, being statistically significant, and more common in those with severe grades. This suggests that androgenetic alopecia patients especially with severe grades are at risk of metabolic syndrome and other cardiovascular diseases.

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“…[23] found no difference in HDL-C and TGs between AGA cases and normal controls. This inconsistency may be partially attributed to the different target populations studied and to the failure to control other confounding factors, such as family history and smoking status.…”

Section: Discussionmentioning

confidence: 99%

Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study

Bakry

Shoeib

Shafiee

et al. 2014

Indian Dermatol Online J

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Context:Although several previous studies have investigated the association of metabolic syndrome (MS) and insulin resistance (IR) with androgenetic alopecia (AGA), the results have been inconsistent.Aim:We attempted to assess the presence of MS and IR in patients with AGA. This may help to detect if AGA can be considered as a clue for underlying serious systemic diseases.Materials and Methods:One hundred male patients with stages III-VII AGA, in Hamilton-Norwood classification, and 100 normal, gender- and age-matched control subjects were included. Anthropometric measures, blood pressure, fasting glucose, fasting insulin, high-density lipoprotein cholesterol, and triglycerides were measured for the all participants. The presence of MS and IR was evaluated.Results:There were statistically significant differences regarding mean values of body weight (P < 0.001), height (P = 0.002), waist circumference (P < 0.001), body mass index (P < 0.001), systolic (P < 0.001), and diastolic blood pressure (P < 0.001), fasting glucose (P < 0.001), triglycerides (P < 0.001), high-density lipoprotein cholesterol (P < 0.01), fasting insulin (P = 0.02) and homeostasis model assessment of insulin resistance (P < 0.001) between cases and controls. A statistically significant association was found between AGA and MS (P = 0.002) and between AGA and IR (P < 0.001). Multiple logistic regression analysis revealed that waist circumference (>102 cm) was the most significant risk factor for developing MS. It increased the risk of MS by 1.25-folds (95% CI = 1.10-1.42, P < 0.001).Conclusion:Our results support the recommendation for assessing MS and IR in all young males with stage III or higher AGA. Early intervention is critical to reduce the risk and complications of cardiovascular disease and type 2 diabetes mellitus later in life.

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Lipid Profiles, Alopecia, and Coronary Disease: Any Relationship?

Cited by 16 publications

References 3 publications

A Comparative Study of Dyslipidaemia in Men and Woman with Androgenic Alopecia

A Comparative Study of Dyslipidaemia in Men and Woman with Androgenic Alopecia

Severe androgenetic alopecia as a maker of metabolic syndrome in male patients of androgenetic alopecia: a hospital based case control study

Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study

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