Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study

Bakry, Ola Ahmed; Shoeib, Mohamed; Shafiee, Maather Kamel El; Hassan, Ahmed A.

doi:10.4103/2229-5178.137776

Cited by 64 publications

(66 citation statements)

References 36 publications

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“…These observations were similar to previous studies. 14,19,20 This was in contrast to other studies.…”

Section: Discussioncontrasting

confidence: 56%

“…This observation was similar to some multicenter studies. 19 In present study metabolic syndrome was seen more commonly in patients with age >40 years in both cases and controls, difference was statistically significant in cases (P<0.0001) but not in controls (P=0.09).…”

Section: Discussionsupporting

confidence: 41%

“…The results of our study were similar to many previous studies. 8,19,25 In contrast, Guzzo et al found no statistically significant difference in lipid indices of cases and controls. 26 The elevated lipid values in androgenetic alopecia patients may contribute, alongside other mechanisms, to the development of cardiovascular disease (CVD).…”

Section: Discussionmentioning

confidence: 89%

“…18,23 In the present study, there was no statistically significant difference(P>0.05) in abdominal obesity (WC>102cm) between case 15/100 (15%) and controls 7/100 (7%), similar to some of previous studies; and in contrast to some. 8,14,15,18,19 Abdominal fat tissue is associated with serious metabolic disorders, such as insulin resistance, hyper-insulinemia, hypertension, increased triglycerides, glucose intolerance, diabetes and metabolic syndrome, coronary heart disease. 15,24 The absence of association in our study could be because of predominance of patients with younger age group in present study.…”

Section: Discussionmentioning

confidence: 99%

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Severe androgenetic alopecia as a maker of metabolic syndrome in male patients of androgenetic alopecia: a hospital based case control study

Tilwani

Dogra

et al. 2017

Int J Res Med Sci

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Background: Several previous studies have investigated the association between androgenetic alopecia (AGA) and metabolic syndrome (MS), with inconsistent results. Objectives of the study were to study the prevalence of metabolic syndrome in male patients of androgenetic alopecia and compare with control population and study the relationship of metabolic syndrome with different grades of AGA.Methods: This prospective hospital based case control study included 100 new clinically diagnosed males of androgenetic alopecia, and age and sex matched control group. Assessment for presence of various components of metabolic syndrome was done following a uniform protocol in cases and controls. AGA was classified as per Hamilton –Narwood classification, grade I to III was classified as mild –moderate and grade IV and higher as severe AGA.Results: Of the 100 male AGA patients (age range 21-50, mean 34.49), 36 had grade II AGA, 24 had grade III AGA, 20 had grade IV AGA, 15 had grade V AGA and 5 had grade VI AGA. Among AGA patients, 60 of patients had mild-moderate AGA and 40 patients had severe AGA. Metabolic syndrome was statistically significantly more common in patients with AGA compared to controls. Among patients of AGA, metabolic syndrome was statistically significantly present in severe AGA compared to mild-moderate AGA. Among the evaluated parameters, like blood pressure, fasting blood sugar, dyslipedemia, abdominal obesity, all were significantly more common in AGA patients compared to controls except abdominal obesity.Conclusions: In the present study, metabolic syndrome was found to be 4.6 times more common in patients of androgenetic alopecia as compared to controls, being statistically significant, and more common in those with severe grades. This suggests that androgenetic alopecia patients especially with severe grades are at risk of metabolic syndrome and other cardiovascular diseases.

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“…These observations were similar to previous studies. 14,19,20 This was in contrast to other studies.…”

Section: Discussioncontrasting

confidence: 56%

Section: Discussionsupporting

confidence: 41%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Severe androgenetic alopecia as a maker of metabolic syndrome in male patients of androgenetic alopecia: a hospital based case control study

Tilwani

Dogra

et al. 2017

Int J Res Med Sci

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“…The findings show significant increases in both total cholesterol and LDL levels, coupled to lower HDL, though the picture for HDL is less clear with some individual case studies reporting no changes or only small, non‐significant reductions in HDL . Total cholesterol and LDL levels were more consistently increased across the studies …”

Section: Associations Between Cholesterol and Hair Pathologiesmentioning

confidence: 99%

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Palmer

Blakeborough

Harries

et al. 2019

Experimental Dermatology

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Lipids and lipid metabolism are critical factors in hair follicle (HF) biology, and cholesterol has long been suspected of influencing hair growth. Altered cholesterol homeostasis is involved in the pathogenesis of primary cicatricial alopecia, mutations in a cholesterol transporter are associated with congenital hypertrichosis, and dyslipidaemia has been linked to androgenic alopecia. The underlying molecular mechanisms by which cholesterol influences pathways involved in proliferation and differentiation within HF cell populations remain largely unknown. As such, expanding our knowledge of the role for cholesterol in regulating these processes is likely to provide new leads in the development of treatments for disorders of hair growth and cycling. This review describes the current state of knowledge with respect to cholesterol homeostasis in the HF along with known and putative links to hair pathologies.

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Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Sally,

Robinson,

Orlow

et al. 2023

JEADV Clinical Practice

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Alopecia is traditionally classified into scarring and nonscarring subtypes, with etiopathologies ranging from androgen‐mediated to immuno‐inflammatory. Over 50% of men and almost 50% of women will experience some form of hair loss in their lifetime. Given this prevalence and the psychosocial significance of hair, understanding the pathophysiology and comorbidities of different types of hair loss is imperative. Other proinflammatory dermatologic disorders, such as psoriasis, are recognised to have systemic manifestations including an increased risk of cardiovascular (CV) disease, and are now considered CV risk‐enhancing conditions. With increased recognition of the importance of systemic inflammation in promoting atherosclerosis, high prevalence, and improved treatment strategies, there is increased interest in establishing whether a similar association between alopecia and cardiovascular disease (CVD) exists. In this manuscript, we aim to review the current literature regarding CV risk in androgenic alopecia (AGA) and alopecia areata (AA). Additionally, we review the literature for cicatricial alopecias and highlight the need for more research into their potential associations with CV risk. Evidence from the identified AGA publications suggests an association of AGA with CV risk factors including hypertension, dyslipidemia, and insulin resistance, as well as with coronary artery disease. For AA, most of the identified studies found an association between AA and CV risk, though the relationships were not always statistically significant. Research on cicatricial alopecias and CV risk is limited and often contradictory. There is great need for more studies regarding the association between various types of alopecia and the development of CVD, and potential mechanisms. Particularly needed are more studies of cicatricial alopecias and potential associated CV risk. While some literature suggests that patients with alopecia have an increased risk of CVD, the lack of concrete evidence represents a notable gap in our current understanding.

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Androgenetic alopecia, metabolic syndrome, and insulin resistance: Is there any association? A case-control study

Cited by 64 publications

References 36 publications

Severe androgenetic alopecia as a maker of metabolic syndrome in male patients of androgenetic alopecia: a hospital based case control study

Severe androgenetic alopecia as a maker of metabolic syndrome in male patients of androgenetic alopecia: a hospital based case control study

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

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